2010
DOI: 10.1086/657135
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Bloodstream Infections Caused by Metallo-β-Lactamase/Klebsiella pneumoniae Carbapenemase–Producing K. pneumoniae among Intensive Care Unit Patients in Greece: Risk Factors for Infection and Impact of Type of Resistance on Outcomes

Abstract: BSIs due to KPC-producing K. pneumoniae resulted in significantly increased mortality. The accurate and rapid detection of these pathogens is necessary for therapeutic considerations and for the implementation of infection control measures to contain them.

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Cited by 172 publications
(152 citation statements)
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“…Some studies found that antibiotic exposure was a risk factor for CRKP acquisition [8,12,17,18]. In contrast, other studies found that CRKP acquisition was not associated with prior antibiotic therapy [9,10,19]. These differences may be related to the high rate of antibiotic exposure during ICU stay among the total study population, making it very difficult to assess the impact of antibiotic exposure [17].…”
Section: Discussionmentioning
confidence: 96%
See 1 more Smart Citation
“…Some studies found that antibiotic exposure was a risk factor for CRKP acquisition [8,12,17,18]. In contrast, other studies found that CRKP acquisition was not associated with prior antibiotic therapy [9,10,19]. These differences may be related to the high rate of antibiotic exposure during ICU stay among the total study population, making it very difficult to assess the impact of antibiotic exposure [17].…”
Section: Discussionmentioning
confidence: 96%
“…Especially for bloodstream infection (BSI) with CRKP, it is clear that the mortality from BSI caused by CRKP is increased compared to BSI caused by susceptible organisms [19,25,26]. In addition, finding CRKP in the bloodstream is associated with worse outcomes compared to isolation from other sites.…”
Section: Discussionmentioning
confidence: 99%
“…Mouloudi et al [45] Double case -control study 59 BSI K. pneumoniae/carbapenem resistance Positive association between KPC producing K. pneumoniae and mortality Michalopoulos et al [46] Retrospective casecontrol study The additional effect of the most common antimicrobial resistance patterns on mortality is comparatively low Tabah et al [48] Prospective multicentre cohort study Resistance not associated with mortality…”
Section: Bsi a Baumannii/carbapenem Resistance No Association With Mmentioning
confidence: 99%
“…Mortality rates of about 41-80% have been reported in literature when infection occurs. 9,10 Given the high degree of antibiotic resistance by these bacteria, therapeutic options are indeed very limited, including variable combinations of aminoglycosides, tigecycline, colistin and fosfomycin. There is much debate in literature about the possible use of carbapenems at high dosage or in combination therapy when K. pneumoniae minimum inhibitory concentrations for imipenem are <4 mg/L.…”
Section: Epidemiologymentioning
confidence: 99%