Bloodstream Infections by Pantoea Species: Clinical and Microbiological Findings from a Retrospective Study, Italy, 2018–2023

Casale, Roberto; Boattini, Matteo; Bianco, Gabriele; Comini, Sara; Corcione, Silvia; Garazzino, Silvia; Silvestro, Erika; De Rosa, Francesco Giuseppe; Cavallo, Rossana; Costa, Cristina

doi:10.3390/antibiotics12121723

Cited by 6 publications

References 79 publications

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Pantoea peritonitis in peritoneal dialysis: a report of two cases and literature review

Monk,

Vijayvargiya,

Hassanein

et al. 2024

Ren Replace Ther

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Background Pantoea spp., a non-encapsulated, non-spore-forming Gram-negative rod bacterium that belongs to the Erwiniaceae family, can be found as a colonizer in humans, plants, and the environment, such as water and soil. Although it has the pathogenic potential to cause disease in humans, patients infected with this pathogen generally experience favorable outcomes. In this article, we present two cases of peritoneal dialysis (PD)-associated peritonitis caused by Pantoea spp. along with literature review. Case presentation The first case is a 66-year-old male patient with end-stage kidney disease (ESKD) on PD, admitted for P. dispersa peritonitis. He presented with abdominal pain and cloudy dialysis effluent, responding well to intraperitoneal vancomycin and cefepime. Antibiotics were deescalated to ceftazidime monotherapy on the basis of antibiotic susceptibility testing. Despite initial recovery with a 3-week course of antibiotics, he developed recurrent peritonitis with P. dispersa, necessitating PD catheter removal and transition to hemodialysis. The second case is a 42-year-old male patient with ESKD on PD who was admitted after 6 days of bloody PD fluid without trauma or associated symptoms. With elevated PD fluid cell counts and positive PD fluid culture showing Streptococcus mitis and P. agglomerans, he was empirically treated for PD-associated peritonitis with intraperitoneal vancomycin and cefepime. Due to a suboptimal response in repeat PD fluid cell counts at day 5, the PD catheter was removed, and he was switched to hemodialysis, followed by a 3-week course of intravenous ceftriaxone. Conclusions We described two unique cases of Pantoea peritonitis in PD, recurrent P. dispersa peritonitis and refractory P. agglomerans peritonitis, both of which resulted in PD catheter removal. Our cases indicate the formation of bacterial biofilm as a potential reason for recurrence of infection and underscores the importance of vigilant monitoring and need for PD catheter removal in Pantoea peritonitis.

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Pantoea peritonitis in peritoneal dialysis: a report of two cases and literature review

Monk,

Vijayvargiya,

Hassanein

et al. 2024

Ren Replace Ther

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Occurrence of Pantoea agglomerans bloodstream infection in neonatal intensive care unit at tertiary hospital in Tanzania: antibiotic susceptibility profile and clinical outcome

Masoud,

Majigo,

Gangji

et al. 2024

Bull Natl Res Cent

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Background Pantoea agglomerans (P. agglomerans) is an environmental gram-negative bacterium that rarely infects humans. P. agglomerans infections have never been reported in Tanzania. We investigated the occurrence of P. agglomerans bloodstream infections among neonates in the Intensive Care Unit (NICU) and their subsequent clinical outcome that occurred in 2019. Methodology Blood samples were collected from neonates with sepsis. A total of 19 P. agglomerans were isolated from 17 infected neonates; two of the neonates had P. agglomerans isolated twice. A total of 14 patient files were retrieved from medical records. Results The mean age of the infected neonates were 3.75 ± 7.95 days. Isolated P. agglomerans showed high sensitivity to the antibiotics particularly chloramphenicol (94.7%), piperacillin-tazobactam (94.7%) and meropenem (94.7%). The mortality rate was 71.4% with 35.7% of infected neonates dying before Antibiotic Susceptibility Test results for appropriate management. The Infection Prevention and Control (IPC) team shut the NICU for thorough decontamination which helped to stop the P. agglomerans occurrence. Conclusions P. agglomerans occurrence at the NICU was an uncommon aetiology pathogen for neonatal sepsis associated with high rates of mortality despite high sensitivity to multiple antibiotics. This calls for the strengthening of infection control measures and introduction of surveillance for environmental pathogens capable of causing human infections.

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Metagenomic analysis of the epiphytic and endophytic microbiota of plum fruits at different storage temperatures

Wang,

Zeng,

Leng

et al. 2024

Preprint

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Background: Fungal decays are one of the primary causes of postharvest losses in fruit, whose onset and development are partially determined by the interactions that occur between the fruit and its resident microbiota. Harvested plums are susceptible to decay pathogens but limited research has been conducted on the microbiota of plums in storage. Therefore, in the present study the composition, diversity, and potential function of the epiphytic and endophytic microbiota of plums during storage at 25 °C and 0 °C was investigated using metagenomic sequencing. Results: Our study indicated that the diversity of the endophytic microbial community remains relatively stable in storage, while the epiphytic community undergoes a notable decline in diversity. Additionally, known pathogens, such as Lasiodiplodia, Diaporthe, Botryosphaeria, Macrophomina, Fusarium, Pseudomonas, and Pantoea, were enriched in decaying fruit, while the reported biocontrol microorganisms Pseudoalteromonas and Aureobasidium were enriched in healthy fruit stored at 25 °C. A negative association was observed between potential biocontrol species and known pathogens within the microbial community network. Notably, decay promoting Filobasidium was specifically found in decayed plums stored at 0 °C, while the beneficial microbes Novosphingobium and Bradyrhizobium were specifically found in healthy fruit. The metagenomic analysis also revealed the presence of antibiotic resistance genes (ARGs) in both endophytic and epiphytic microbial communities in plum, and were primarily associated with members of the phylum Pseudomonadota as determined by host tracking analysis. Conclusions: Findings of the study provide insight on the community dynamics that occur in the endophytic and epiphytic microbiome in plums during storage at different temperatures (25 °C and 0 °C) which can be used to develop a comprehensive strategy for the management of postharvest diseases in plum and potentially other stone fruit crops (peaches, apricots, and cherries).

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Bloodstream Infections by Pantoea Species: Clinical and Microbiological Findings from a Retrospective Study, Italy, 2018–2023

Cited by 6 publications

References 79 publications

Pantoea peritonitis in peritoneal dialysis: a report of two cases and literature review

Pantoea peritonitis in peritoneal dialysis: a report of two cases and literature review

Occurrence of Pantoea agglomerans bloodstream infection in neonatal intensive care unit at tertiary hospital in Tanzania: antibiotic susceptibility profile and clinical outcome

Metagenomic analysis of the epiphytic and endophytic microbiota of plum fruits at different storage temperatures

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