Bloodstream Infections and Antimicrobial Resistance of Responsible Pathogens in Ukraine: Results of a Multicenter Study (2013-2015)

Salmanov, Aidyn G; Voronenko, Yu. V.; Vozianov, S.O.; Shunko, Yelizaveta Ye; Mamenko, M.E.; Verner, O.M.; Mykhalchuk, V. M.; Vydyborets, Stanislav; Shkorbotun, Volodymyr O; Beketova, Halyna V.; Оkhotnikova, O.M.; Goryainova, Nadiya V; Oshlianska, Olena; Laksha, Olga; Bielova, Olena; Shuba, Volodymyr; Osadcha, Tetyana M

doi:10.36740/wlek201911101

Cited by 6 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An assessment of eight randomly selected strains cannot replace broader surveillance efforts. However, considering the scarcely available information on the local epidemiology of carbapenemases in the Ukraine [31][32][33] and, in contrast, the frequent detection of carbapenem resistance in clinical A. baumannii isolates from severely infected Ukrainian patients [28,29], these data may at least provide a piece in the puzzle of global antimicrobial resistance. Future studies on the local epidemiology of carbapenem resistance in Ukrainian A. baumannii isolates are necessary to further amend this preliminary information.…”

Section: Discussionmentioning

confidence: 99%

“…were particularly abundant as part of the wound flora in war-injuries in later stages of the wound consolidation process, while Gram-positive bacteria dominated at the beginning [27]. Carbapenem-resistance in A. baumannii bloodstream isolates from Ukrainian hospitals is high, with a prevalence of 63.2% reported in a multi-center study of Ukrainian hospitals between 2013 and 2015 [28]. A recent study from 2019 showed that 78.6% of the A. baumannii isolates causing healthcare associated infections in a Ukrainian intensive care unit were carbapenem-resistant [29].…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii Isolated from War-Injured Patients from the Eastern Ukraine

Higgins

Hagen

Podbielski³

et al. 2020

Antibiotics

View full text Add to dashboard Cite

Recently, a total of 32 carbapenem- and fluoroquinolone-resistant Acinetobacter baumannii (Ab) isolates was isolated from war-injured patients who were treated at German Bundeswehr Hospitals, and preliminarily typed by “DiversiLab” repetitive elements sequence-based (rep-) PCR. Core genome-based sequence typing was also used to provide more detailed epidemiological information. From the clusters observed by rep-PCR, selected Ab strains were subjected to Next Generation Sequencing (NGS) in order to compare them with international outbreak-associated Ab strains and to identify MLST (multi-locus sequence type) lineages, as well as to identify known resistance genes. Accordingly, NGS indicated higher diversity than rep-PCR, but also confirmed likely transmission events. The identified acquired carbapenem-resistant genes comprised blaOXA-23, blaOXA-72 and blaGES-12, as well as various other intrinsic and acquired resistance-associated genetic elements. All isolates clustered with the previously identified international clonal lineages IC1, IC2, IC6 and IC7, with corresponding Pasteur sequence types ST1, ST2, ST78 and ST25, respectively. In conclusion, the assessment confirmed a broad spectrum of resistance-associated genes in Ab isolated from war-injured patients from the Eastern Ukraine, and provided the first insights into locally abundant clonal lineages.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii Isolated from War-Injured Patients from the Eastern Ukraine

Higgins

Hagen

Podbielski³

et al. 2020

Antibiotics

View full text Add to dashboard Cite

show abstract

“…12 Gram-negative bacteria, particularly Enterobacteriaceae and P. aeruginosa have emerged as the predominant BSIcausing pathogens. 13 The increasing rates of β-lactamrelated antibiotic resistance, the spread of bacteria with…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Ceftazidime/Avibactam Administration in Enterobacteriaceae and Pseudomonas aeruginosa Bloodstream Infections by Monte Carlo Simulation

Dai¹,

Chang²,

Zhou³

et al. 2021

DDDT

View full text Add to dashboard Cite

Purpose: To evaluate the administration regimen of ceftazidime/avibactam (CZA) for bloodstream infections caused by Enterobacteriaceae and Pseudomonas aeruginosa. Methods: The minimal inhibitory concentrations (MICs) of CZA against Enterobacteriaceae and P. aeruginosa isolated from blood cultures at member hospitals in BRICS (Blood Bacterial Resistant Investigation Collaborative System) in 2019 were determined by broth micro-dilution methodology. A 10,000-patient Monte Carlo simulation (MCS) was used to calculate the probability of target attainment (PTA) and cumulative fraction of response (CFR) for different CZA dosage regimens to evaluate their efficacies and optimize the best initial dosage regimen. Results: Altogether, 6487 Enterobacteriaceae and P. aeruginosa strains were isolated from the blood cultures. The overall CZA resistance rate was 2.31%, of which the Enterobacteriaceae and P. aeruginosa rates were 1.57% and 14.29%, respectively. The MCS showed that the greater the MIC value, the worse the therapeutic effect. When the CZA MIC was ≤8 mg/L, the standard dose (2.5g iv q8h) achieved 90% PTA in the subset of patients with creatinine clearance (CrCl) values from 51 to 120 mL/min. Although the high-dose regimen (3.75g iv q8h) achieved 90% PTA in patients with CrCl values from 121 to 190 mL/min, implementing the low-dose regimen (1.25g iv q8h) was also effective for patients in the 51-89 mL/min CrCl range. Generally, the high-dose regimen (3.75g iv q8h) reached 90% CFR against all of the strains. Conversely, in patients with CrCl values of 121-190 mL/min, the standard dose (2.5g iv q8h) failed to reach 90% CFR against some Enterobacteriaceae members and P. aeruginosa. When the dose was reduced to the low-dose regimen (1.25g iv q8h), no patients reached 90% CFR against some Enterobacteriaceae members and P. aeruginosa. Conclusion: CZA has good antibacterial activity against Enterobacteriaceae and P. aeruginosa in bloodstream infections. Clinicians could make individualized treatment regimens in accordance with the sensitivity of the strains and the level of renal function in their patients to best predict the drug-related clinical responses.

show abstract

“…Current guidelines for the treatment of infections recommend the immediate prescription of antimicrobial medicines as soon as the infection is diagnosed. Broad spectrum antimicrobials should be prescribed even before the culture results are known in order to cure the most probable infection agents [3][4][5][6][7][8]. However, the literature data on the etiology and resistance of pathogens caused Reproductive Tract Infections varies considerably [9,10].…”

Section: Introductionmentioning

confidence: 99%

Vaginal Cuff Infection After Hysterectomy in Ukraine

Salmanov

Vitiuk

Hrynchuk³

et al. 2021

Wiad Lek

Self Cite

View full text Add to dashboard Cite

The aim: To obtain the first estimates of the current prevalence of vaginal cuff infection after hysterectomy and antimicrobial resistance of causing pathogens in Ukraine. Materials and methods: We performed a retrospective multicenter cohort study was based on surveillance data. The study population consisted of women who had an abdominal, vaginal or laparoscopic hysterectomy from 2017 to 2019 in 7 women hospitals of Ukraine. Definitions of vaginal cuff infections were used from the Centers for Disease Control and Prevention’s National Healthcare Safety Network, USA. Results: Total 12.6% women’s after hysterectomy had vaginal cuff infections. Of these cases, 20.3% after abdominal, 15.5% vaginal and 4.1% laparoscopic hysterectomy were identified. The predominant pathogens of VCUF infections were: Escherichia coli (18.6%), Enterobacter spp. (12.4%), Staphylococcus aureus (10.8%), Streptococcus spp. (9,7%), Klebsiella pneumoniae (8.2%), Pseudomonas aeruginosa (7.6%), Enterococcus faecalis (7,0%) and Proteus spp. (7.0%). Methicillin-resistance was observed in 12.9% of S. aureus (MRSA) and 9.7% CoNS. Carbapenem resistance was identified in 7.3% of P.aeruginosa isolates. Resistance to thirdgeneration cephalosporins was observed in 8.9% K. pneumoniae and E.coli 11.9% isolates. The overall proportion of extended spectrum beta-lactamases (ESBL) production among Enterobacteriaceae was 22.7%. The prevalence of ESBL production among E. coli isolates was significantly higher than in K. pneumoniae (32.6%, vs 12.3%). Conclusions: Vaginal cuff infections in women after hysterectomy are common in Ukraine and most of these infections caused by antibiotic-resistant bacteria. The incidence of VCUF infections after hysterectomy differs depending on the type of surgical procedure.

show abstract

Bloodstream Infections and Antimicrobial Resistance of Responsible Pathogens in Ukraine: Results of a Multicenter Study (2013-2015)

Cited by 6 publications

References 0 publications

Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii Isolated from War-Injured Patients from the Eastern Ukraine

Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii Isolated from War-Injured Patients from the Eastern Ukraine

Evaluation of Ceftazidime/Avibactam Administration in Enterobacteriaceae and Pseudomonas aeruginosa Bloodstream Infections by Monte Carlo Simulation

Vaginal Cuff Infection After Hysterectomy in Ukraine

Contact Info

Product

Resources

About