Bloodstream Infections among Heart Transplant Recipients

Rodríguez, C.; Muñóz, Patricia; Rodríguez‐Créixems, Marta; Yáñez, Javier; Palomo, Jesús; Bouza, Emilio

doi:10.1097/01.tp.0000188953.86035.2d

Cited by 62 publications

(55 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…BSI among heart transplant recipients was published less often in the literature compared to BSI among other SOT types. Gram negative microorganisms predominated (57.9%) in our centre among heart transplant recipients, which was in accordance with previous studies (55.3%-57%) (11,12). The most frequently isolated microorganism was E. coli from BSI among SOT recipients in our centre, of which 57.7% were ESBL-producing.…”

Section: Discussionsupporting

confidence: 79%

See 1 more Smart Citation

Bloodstream Infections among Solid Organ Transplant Recipients: Eight Years’ Experience from a Turkish University Hospital

Yeşilkaya¹,

Azap²,

Demirkaya³

et al. 2013

Balkan Med J

View full text Add to dashboard Cite

Background: Bloodstream infections (BSI) are frequently seen after solid organ transplantation. The incidence of bloodstream infections differs among the types of transplantation. The microbiological features and antimicrobial resistance patterns change from centre to centre. Aims: To evaluate the incidence and spectrum of aetiological agents of bloodstream infections among solid organ transplantation recipients.Study Design: Retrospective descriptive study.Methods: Medical records of solid organ transplant recipients in the period between January 1 st 2004 and August 15 th 2012 were assessed retrospectively. The study population comprised 927 (64 heart, 556 kidney, 307 liver) consecutive recipients. Bloodstream infections were divided into three groups according to the onset time of bloodstream infections after transplantation: early, mid-term and late. The incidence and microbiological features of bloodstream infections were evaluated.Results: The number of bloodstream infection episodes was 317 in 191 recipients which was distributed as 228 (72%) in liver, 70 (22%) in kidney and 19 (6%) in heart transplantation. Ninety-eight 98 (30.9%) of the episodes were diagnosed within the early period, 134 (42.3%) within the mid-term and 85 (26.8%) in the late period. Early and mid-term bloodstream infections were seen statistically more often in liver than in kidney or heart transplantation (p=0.01 and p=0.031, respectively). Late bloodstream infections were also common in liver transplant recipients which was not statistically significant (p=0.229).Conclusion: Liver transplant recipients are at the highest risk for developing BSI after transplantation in early, mid-term and late periods.

show abstract

Section: Discussionsupporting

confidence: 79%

“…The percentage of candidaemia after SOT in our centre (2.9%) was similar to previous reports (1.7%-7%) (1,6,10,11). The results of both the identification and antifungal susceptibilities of five Candida isolates yielded no fluconazole resistance.…”

Section: Discussionsupporting

confidence: 78%

Bloodstream Infections among Solid Organ Transplant Recipients: Eight Years’ Experience from a Turkish University Hospital

Yeşilkaya¹,

Azap²,

Demirkaya³

et al. 2013

Balkan Med J

View full text Add to dashboard Cite

show abstract

“…Thoracic organ transplant recipients are uniquely susceptible to pulmonary complications (15). Our data show that 50% of the bacteremias in the first posttransplant year were of pulmonary origin.…”

Section: Discussionmentioning

confidence: 75%

Bacteremia in Lung Transplant Recipients in the Current Era

Husain

Chan

Palmer

et al. 2006

American Journal of Transplantation

View full text Add to dashboard Cite

Current trends in the epidemiology, outcome and variables influencing mortality in bacteremic lung transplant recipients have not been fully described. We prospectively studied bacteremias in lung transplant recipients in a multicenter study between 2000-2004. Bacteremia was documented in 56 lung transplant recipients, an average of 172 days after transplantation. Multiple antibiotic resistance was documented in 48% of the isolates; these included 57% of the Gramnegative and 38% of the Gram-positive bacteria. Pulmonary infection was the most common source of resistant gram-negative bacteremias. Mortality rate at 28 days after the onset of bacteremia was 25% (14/56). Mechanical ventilation and abnormal mental status correlated independently with higher mortality (p < 0.05 for both variables). Bacteremia remains a significant complication in lung transplant recipients and is associated with considerable mortality. Recognition of variables portending a high risk for antibiotic resistance and for poor outcome has implications relevant for optimizing antibiotic prescription and for improving outcomes in lung transplant recipients.

show abstract

“…The situation is explained by an increased population of patients receiving anti-cancer chemotherapy, immunosuppressive medicine after organ transplantation and invasive surgical procedures. These patients are classified as a high-risk group susceptible to sepsis (1)(2)(3)(4). The death rate of GNB infection patients will be significant decreased if a prophylaxis therapy is clinically available.…”

Section: Introductionmentioning

confidence: 99%

Protection of Immuno-Compromised Mice from Lethal Infection of Klebsiella Pneumonia by rAAV2-BPI23-Fcγ1 Gene Transfer

Kong

et al. 2008

Cell Mol Immunol

View full text Add to dashboard Cite

Bloodstream Infections among Heart Transplant Recipients

Abstract: BSIs have decreased in HT recipients, but still contribute to mortality, mainly if related to pneumonia or polymicrobial infections. Reduction of early postoperative complications and viral infections are amenable goals that may further reduce BSI in this population.

Cited by 62 publications

References 34 publications

Bloodstream Infections among Solid Organ Transplant Recipients: Eight Years’ Experience from a Turkish University Hospital

Bloodstream Infections among Solid Organ Transplant Recipients: Eight Years’ Experience from a Turkish University Hospital

Bacteremia in Lung Transplant Recipients in the Current Era

Protection of Immuno-Compromised Mice from Lethal Infection of Klebsiella Pneumonia by rAAV2-BPI23-Fcγ1 Gene Transfer

Contact Info

Product

Resources

About