Blood volume in pre-eclampsia: Fantasy and reality

Haemodynamic changes in gestational proteinuric hypertension: the effects of rapid volume expansion and vasodilator therapy

“…Tt has been suggcsted that acute volume expansion in pregnancy hypertension may cause worsening of the condition (Assali & Vaughn 1977). Our findings, howevcr, do not support this view.…”

Simultaneous investigations of maternal cardiac output and fetal blood flow during hypervolemic hemodilution in preeclampsia — preliminary observations

“…In contrast to colloidosmotic pressure [17]. The elevated hy-ASSALI et al [1] we support the opinion of drostatic intervillous pressure, induced by plas-GROENENDUK et al [8] that plasma expansion ma volume expansion might be responsible for in pre-eclampsia is of potential benefits to the net flow of water into the fetal circulation, maintain a normal cardiac index such as the Nevertheless improved blood flow properties in physiological conditions in normal pregnancy, the course of plasma expander therapy may Hemodilution with oncotic active drugs also also play an additive role in the fetoplacental improves blood flow behavior in microcircula-water transfer. Further studies are warranted tion [9].…”

Maternal Plasma and Amniotic Fluid Prolactin Levels in Normal and Hypertensive Pregnancy

“…The aetiology of pre-eclampsia is not known but vasoconstriction due to increased vascular reactivity to pressor agents such as angiotensin probably plays a role (Gant et al, 1976;Assali and Vaughn, 1977). Experiments in the rat and rabbit show that prolactin may antagonize the pressor effects of angiotensin and norepinephrine with reduction in blood pressure (Manku et al, 1973;Bryant et al, 1973;Mati et al, 1977).…”