Blood Viscosity as a Factor in Sensorineural Hearing Impairment

Browning, George G.; Gatehouse, Stuart; Lowe, G. D. O.

doi:10.1016/s0140-6736(86)92261-0

Cited by 92 publications

(47 citation statements)

References 10 publications

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“…In order to identify potential risk factors commonly related to impaired vascular perfusion, a limited number of studies has evaluated the possible role of different cardiovascular and thrombophilic factors in the pathogenesis of ISSNHL. However, all the available studies have only assessed a few factors, often in a limited number of patients [Marcucci et al, 2005;Lalanne et al, 1992;Einer et al, 1994;Browning et al, 1986;Mercier et al, 1999]. In our study, the relevant role of diabetes mellitus, particularly in patients under insulin therapy, of total cholesterol levels, and of clustering multiple cardiovascular risk factors was demonstrated.…”

Section: Discussionsupporting

confidence: 50%

Diabetes, Cardiovascular Risk Factors and Idiopathic Sudden Sensorineural Hearing Loss: A Case-Control Study

et al. 2009

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Aims/Hypothesis: Idiopathic sudden sensorineural hearing loss (ISSNHL) represents an acute inner ear disorder with an overall incidence of 5–20/100000 individuals per year in western countries. No clear causes for this disease have been found so far, but cochlear ischemia has been hypothesized as one of the etiopathological mechanisms. The aim of our study was to assess the role of diabetes and traditional cardiovascular risk factors in the pathogenesis of ISSNHL. Materials/Methods: Case-control study of 141 patients (75 males/66 females) matched for age and gender. Cases were affected by ISSNHL, defined as a sudden hearing loss ≧30 dB, within 3 frequencies, developing over 72 h. The control group was composed of 271 sex- and age-matched subjects (142 males/129 females) who agreed to participate in this observational study and provided blood samples for laboratory investigations. Cardiovascular risk factors examined were: diabetes mellitus, smoking history, hypercholesterolemia, hypertriglyceridemia and hypertension. Results: On the univariate analysis, diabetes prevalence was higher in the ISSNHL group (15.6%) compared to controls (8.5%) (p = 0.03). Also hypercholesterolemia was significantly more frequent in the ISSNHL group compared to the control population. There were no statistically significant differences between the 2 populations concerning other cardiovascular risk factors. The risk of ISSNHL tended to increase as the number of cardiovascular risk factors increased (p for linear trend = 0.018). Conclusions: Our findings suggest that diabetes mellitus, hypercholesterolemia and a high burden of cardiovascular risk factors are associated with the risk of ISSNHL.

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Section: Discussionsupporting

confidence: 50%

Diabetes, Cardiovascular Risk Factors and Idiopathic Sudden Sensorineural Hearing Loss: A Case-Control Study

et al. 2009

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“…Another study reports that nicotine changes the blood characteristics, and such changes harm cochlear irrigation. The cochlear artery ends its irrigation at the site of the inner hair cells, and that is why tobacco introduces predominantly progressive hearing loss, being the higher frequencies involved first 12 . In order to understand the effects of smoking on the auditory system, other studies need to be performed, principally those using evaluation procedures that may detect early hearing impairments such as high frequency audiometry, otoacoustic emissions, and auditory evoked potential.…”

Section: Discussionmentioning

confidence: 99%

“…Another study using animals found nicotine receptors in hair cells, thus indicating that smoking may have direct ototoxic impact upon hair cell function and reduce the potential of the hearing neurotransmission organ 10 . As less oxygen is available to the organ of Corti, there is less energy available for the cochlea and possibly more hair cell injury 9,11,12 . Some smokers complain of tinnitus, an indication of peripheral or central disorders.…”

Section: Introductionmentioning

confidence: 99%

O cigarro como um fator de risco para alterações auditivas

Paschoal¹,

Azevedo²

2009

Braz. j. otorhinolaryngol. (Impr.)

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Smoki ng is a public health concern and we are still unsure of its relation with auditory problems. Aim: To study the effects of cigarette smoking in auditory thresholds, in otoacoustic emissions and in their inhibition by the efferent olivocochlear medial system. Materials and Methods: 144 adults from both genders, between 20 and 31 years of age, smoking and non-smoking individuals were submitted to conventional and high-frequency audiometry, transient stimuli otoacoustic emissions and suppression effect investigation. Results: smokers presented worse auditory thresholds in the frequencies of 12.500Hz in the right ear and 14,000 kHz in both ears. Regarding the otoacoustic emissions, smokers group presented a lower response level in the frequencies of 1,000Hz in both ears and 4,000Hz in the left ear. Among smokers there were more cases of cochlear dysfunction and tinnitus. Conclusion: Our results suggest that cigarette smoking has an adverse effect on the auditory system.

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“…While acute and complete interruption of the blood supply induces permanent auditory damage, vasospasm secondary to various physiological and nonphysiological conditions could account for transient hearing loss [26]. Other hypotheses have suggested the role of hemostatic and hemorheologic disorders in acute auditory impairments [27,29].…”

Section: The Nosological Issuementioning

confidence: 99%

Idiopathic Sudden Sensorineural Hearing Loss

Huy¹

1999

Otorhinolaryngol Nova

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Idiopathic sudden sensorineural hearing loss (ISSHL) is a syndrome covering several heterogenous entities resulting from different pathogenetic mechanisms. No argument allows to consider ISSHL a therapeutic emergency. Consequently, poor outcome cannot be attributed to therapeutic delay. The various therapeutic strategies currently recommended are highly empirical and should be questioned in terms of cost-effectiveness. The methodological requirements of clinical trials come up against hardly surmountable obstacles, namely the difficulty in gathering sufficient numbers of various subgroups within a reasonable period of time and limitations to assess the physiopathological process underlying ISSHL. At this time, the audiogram is the unique tool which may help clinicians to identify these entities and provide a classification based on the types of hearing loss. New investigation tests are required for improving our approach to ISSHL.

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Blood Viscosity as a Factor in Sensorineural Hearing Impairment

Cited by 92 publications

References 10 publications

Diabetes, Cardiovascular Risk Factors and Idiopathic Sudden Sensorineural Hearing Loss: A Case-Control Study

Diabetes, Cardiovascular Risk Factors and Idiopathic Sudden Sensorineural Hearing Loss: A Case-Control Study

O cigarro como um fator de risco para alterações auditivas

Idiopathic Sudden Sensorineural Hearing Loss

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