Blood Vessel Invasion in Breast Carcinoma

Noguchi, Yoshikazu; Amano, Tetsuya; Matsumoto, Akihiko; Sasaki, Hideyuki; Katayama, Kiyofumi; Okada, Ken-ichi; Tomita, Yoshihiko; Arita, Eiji; Arita, Masataka; Jinno, Katsumi; Sumikawa, Takayuki; Ito, Takaaki; Kitamura, Hajime

doi:10.3919/ringe1963.46.928

Cited by 18 publications

(23 citation statements)

References 4 publications

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“…At present, despite recent advances in adjuvant therapies, few patients with peritoneal or haematogenous metastasis can survive for more than 1 year, indicating the strong association of both types of metastasis with poor prognosis. In addition, the association between venous vessel invasion of tumour cells and poor prognosis has been well described for various malignancies including gastric carcinomas (Noguchi, 1990;Gabbert et al, 1991). Therefore, our result that tumour vasculature has been evaluated as an important and independent prognostic factor is meaningful.…”

Section: Discussionsupporting

confidence: 53%

Association of tumour vasculature with tumour progression and overall survival of patients with non-early gastric carcinomas

Tanigawa

Amaya²,

Matsumura³

et al. 1997

Br J Cancer

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Summary In order to investigate the relationship between intratumoral vasculature and progression of gastric carcinomas and between vessel counts and survival of patients with non-early gastric carcinoma, we counted the intratumoral microvessels and compared their numbers with clinicopathological parameters, as well as with the patients' survival. Microvessels were stained with anti-CD34 monoclonal antibody before counting by microscopy (x200). In a group of 181 patients who had undergone tumour resection and were followed for more than 24 months the vessel counts for 83 patients with stage IV disease were significantly higher than those for patients with any other stage of disease. Among various clinicopathological variables, haematogenous metastasis, lymph node metastasis, peritoneal metastasis, stage IV disease and non-curative resection were more frequent in the patients with highly vascularized tumours (intratumoral vessel count > 155) than in those with less vascularized tumours. As a classification of stage IV disease such as haematogenous or peritoneal metastasis generally indicates non-curative resection, it can be considered that the development of stage IV disease is associated with the increase in tumour angiogenesis. Both univariate and multivariate analyses showed that the intratumoral vessel count was significantly predictive of overall survival, when tested as either a continuous or dichotomous variable. Cox hazards model analysis showed that the vessel count was one of the significant and independent prognostic variables. Patients with highly vascularized tumours were significantly more likely to die than those with less vascularized tumours. Assessment of tumour vasculature may therefore be important, not only for its prognostic value, but also as it may help to predict responses to angiogenesis-inhibiting agents.

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Section: Discussionsupporting

confidence: 53%

Association of tumour vasculature with tumour progression and overall survival of patients with non-early gastric carcinomas

Tanigawa

Amaya²,

Matsumura³

et al. 1997

Br J Cancer

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“…This mechanism of liver metastasis has been supported by both clinicopathological analyses of resected specimens, showing a relationship between venous invasion and liver metastasis [11], and by recently developed techniques in molecular biology (elucidation of, for example, adhesion molecules and angiogenetic factors) [1][2][3]. Venous invasion is considered to be closely related to liver metastasis [11,12], although occasionally venous invasion cannot be identified in the surgical specimens of patients with liver metastasis. The significance of blood vessel invasion has been debated.…”

Section: Discussionmentioning

confidence: 97%

Liver metastasis in gastric cancer with particular reference to lymphatic advancement

et al. 2001

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“…where attachment and proliferation occurred (Noguchi, 1990). The main locus of vascular invasion was seen most frequently in the submucosal layer (Noguchi.…”

Section: Discussionmentioning

confidence: 99%

Recurrences and related characteristics of gastric cancer

Maehara

Emi²,

Baba³

et al. 1996

Br J Cancer

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Summary We analysed data on 1117 patients with gastric cancer who were treated by curative resection.Attention was focused on invasion and a recurrence of the cancer. Based on a univariate analysis, death following a recurrence and prognosis were related to age of the patients, size of the tumour, tumour location, tumour tissue differentiation, growth pattern, depth of invasion, lymphatic and vascular invasion and lymph node metastasis. In proportion to the growth potential, determined by the level of proliferating cell nuclear antigen (PCNA) labelling, the death related to a recurrence was increased and the prognosis was poorer. Multivariate analysis showed that the three factors of serosal invasion, PCNA labelling index and lymph node dissection were independent prognostic factors. When sites of recurrence were analysed regarding each depth of invasion, haematogenous recurrence, in particular in the liver, occurred even in cases of an early invasion and many types of recurrences, including peritoneal recurrence, were noted in patients with an advanced state of invasion.

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Blood Vessel Invasion in Breast Carcinoma

Cited by 18 publications

References 4 publications

Association of tumour vasculature with tumour progression and overall survival of patients with non-early gastric carcinomas

Association of tumour vasculature with tumour progression and overall survival of patients with non-early gastric carcinomas

Liver metastasis in gastric cancer with particular reference to lymphatic advancement

Recurrences and related characteristics of gastric cancer

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