Blood urea nitrogen-to-creatinine ratio in the general population and in patients with acute heart failure

Abstract

In patients with AHF, BUN/creatinine higher than age-specific and sex-specific normal range is associated with worse prognosis independently from both creatinine and BUN. CLINICAL TRIALS: gov identifier NCT00328692 and NCT00354458.

Leucine-rich Repeat-containing G-protein Coupled Receptor 5 Gene Overexpression of the Rat Small Intestinal Progenitor Cells in Response to Orally Administered Grape Exosome-like Nanovesicles

“…As BUN and Cr are well-recognized biomarkers for estimation of kidney function and damage,[17] that performed in this study. Analysis of data by SPSS showed that statistically, there is no significant difference between the two groups receiving GELNs and the PBS group ( P > 0.05) [Figure 4].…”

Blood urea nitrogen to creatinine ratio in acute heart failure: an old concept brought to reality?

“…Patients with elevated BUN/Cr were more prone to improve renal function during hospitalisation and to develop WRF after discharge 8. Intriguingly, in the work of Matsue et al 4 BUN/Cr was not related to inhospital WRF, a finding that could be explained by differences among characteristics of patients and criteria used to define WRF among studies 7 8…”

“…In their Heart paper, Matsue et al ,4 evaluate the prognostic implications of the BUN to creatinine ratio (BUN/Cr) in a cohort of patients with AHF, using the normal values previously determined in a general population cohort. Indeed, an age-specific and sex-specific normal range of BUN/Cr was determined in a cohort of 4484 subjects with a mean age of 44±11 years, 55% women and most of them Caucasians.…”

“…Indeed, an age-specific and sex-specific normal range of BUN/Cr was determined in a cohort of 4484 subjects with a mean age of 44±11 years, 55% women and most of them Caucasians. Then, the authors evaluated the adequacy of such abnormal ranges on the incidence of WRF during hospitalisation, and short-term adverse clinical outcomes in 1956 patients with AHF from the PROTECT (Placebo-Controlled Randomized Study of the Selective Adenosine A1 Receptor Antagonist Rolofylline for Patients Hospitalized with Acute Decompensated Heart Failure and Volume Overload to Assess Treatment Effect on Congestion and Renal Function) study 4. This latter cohort, with a higher than normal BUN/Cr—representing 24.7% of the patients—was not related with the risk of WRF but it was related with the risk of 180-day death and the composite of death or cardiovascular or renal rehospitalisations through day 60.…”

Heartbeat:Blood urea nitrogen to creatinine ratio predicts outcome in acute heart failure

“…Thus, neurohormonal activity is reflected in the BUN/creatinine ratio which effectively ‘normalizes’ BUN for the degree of renal dysfunction, as measured by the creatinine level. To investigate the prognostic value of the BUN/creatinine ratio in AHF, Matsue and colleagues1 first defined age and sex specific normal ranges. Even in normal individuals, there is wide variation in the BUN/creatinine ratio, an increase with age, and higher levels in women compared to men.…”