Blood typing using microstructured waveguide smart cuvette

Zanishevskaya, Anastasiya A.; Shuvalov, A. A.; Skibina, Julia S.; Tuchin, Valery V.

doi:10.1117/1.jbo.20.4.040503

Cited by 9 publications

(5 citation statements)

References 8 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For applications in endoscopy, the sapphire waveguide cross‐section might need to be modified from what is discussed in this paper in order to reduce the endoscope dimensions, while for other applications, single‐mode operation might be a better alternative to a few‐mode guidance regime employed by our waveguides. Furthermore, the sapphire shaped crystals could be used as waveguides and cuvettes for studies of condensed matter, gases, plasmas and biological systems using various intra‐waveguide sensing modalities . Finally, they could serve as elements of the imbedded equipment for the THz nondestructive operational control of mechanical systems and products of the petroleum industry, the open‐space research equipment in THz astrophysics, and the multispectral systems for simultaneous sensing in THz, IR, VIS, and UV ranges.…”

Section: Discussionmentioning

confidence: 99%

“…We believe that the proposed configuration of the THz intra‐waveguide interferometric sensor is innovative compared to the other existing intra‐waveguide sensor arrangements, as it relies on detection of the amplitude changes in the interference pattern between the two core‐guided modes, rather than tracking refractive index changes of a single core‐guided mode, as done in other works . The key advantage of our arrangement is that the amplitude sensitive detectors are used to detect phase information via interferogram acquisition.…”

Section: High‐temperature Thz Intra‐waveguide Interferometric Sensingmentioning

confidence: 99%

See 1 more Smart Citation

Sapphire Photonic Crystal Waveguides for Terahertz Sensing in Aggressive Environments

Katyba

Zaytsev

Chernomyrdin

et al. 2018

Advanced Optical Materials

View full text Add to dashboard Cite

IntroductionOver the last decade, THz spectroscopy has been used with success in a variety of fundamental and practical applications, [1,2] which among others include: spectroscopy of condensed matter [3][4][5] and gases, [6] medical diagnosis [7,8] and therapy, [9] Terahertz (THz) frequency range opens significant opportunities in various fundamental and applied fields including condensed matter physics and chemistry, biology and medicine, public security and nondestructive testing. Despite significant advances in THz instrumentation, the problem of THz sensing in harsh environments, particularly at high temperatures and pressures, remains acute due to the lack of THz materials and optical components capable for operation under the extreme conditions. To address this problem, the THz hollow-core photonic crystal sapphire waveguides that are fabricated using shaped crystal growth technique are developed. Numerical analysis and experimental study show that the proposed waveguides operate in a fewmode regime and allow for the broadband transmission of THz pulses with small dispersions and low propagation losses. Thanks to the unique physical properties of sapphire, the proposed waveguides are capable of operating in a variety of aggressive environments. As an example, the developed waveguides are used to conduct the intra-waveguide interferometric sensing of phase transitions in sodium nitrite films at high temperatures. It is believed that the proposed sapphire-based material's platform has strong potential for developing THz guided optics for applications in intra-waveguide spectroscopy, interferometry, and remote sensing in aggressive environments. Sapphire Terahertz Waveguides

show abstract

Section: Discussionmentioning

confidence: 99%

Section: High‐temperature Thz Intra‐waveguide Interferometric Sensingmentioning

confidence: 99%

Sapphire Photonic Crystal Waveguides for Terahertz Sensing in Aggressive Environments

Katyba

Zaytsev

Chernomyrdin

et al. 2018

Advanced Optical Materials

View full text Add to dashboard Cite

show abstract

“…This approach was successfully tested for the detection of Al cations in solution by doping the poly(methyl methacrylate) film with 8-hydroxyquinoline sensing molecules [61]. Another prospective application of functionalized MOFs is the specific detection of target molecules or blood components in point-of-care devices [62].…”

Section: Biosensors For the Selective Detection Of Specific Moleculesmentioning

confidence: 99%

Functionalized Microstructured Optical Fibers: Materials, Methods, Applications

et al. 2020

Self Cite

View full text Add to dashboard Cite

Microstructured optical fiber-based sensors (MOF) have been widely developed finding numerous applications in various fields of photonics, biotechnology, and medicine. High sensitivity to the refractive index variation, arising from the strong interaction between a guided mode and an analyte in the test, makes MOF-based sensors ideal candidates for chemical and biochemical analysis of solutions with small volume and low concentration. Here, we review the modern techniques used for the modification of the fiber’s structure, which leads to an enhanced detection sensitivity, as well as the surface functionalization processes used for selective adsorption of target molecules. Novel functionalized MOF-based devices possessing these unique properties, emphasize the potential applications for fiber optics in the field of modern biophotonics, such as remote sensing, thermography, refractometric measurements of biological liquids, detection of cancer proteins, and concentration analysis. In this work, we discuss the approaches used for the functionalization of MOFs, with a focus on potential applications of the produced structures.

show abstract

“…In addition to fiber holding, the smart cuvette also can control meniscus formation that is important for light coupling when the fiber is filled with liquid. This type of cuvette has been served as a basic replaceable element of a biosensor for blood typing [28]. Microscope objectives (40´) are used to launch the white light from a halogen lamp into the fiber and collect the outcoming radiation.…”

Section: Impact Omentioning

confidence: 99%

Enabling magnetic resonance imaging of hollow-core microstructured optical fibers via nanocomposite coating

Noskov

Zanishevskaya²,

Shuvalov³

et al. 2019

Opt. Express

Self Cite

View full text Add to dashboard Cite

Optical fibers are widely used in bioimaging systems as flexible endoscopes that are capable of low-invasive penetration inside hollow tissue cavities. Here, we report on the technique that allows magnetic resonance imaging (MRI) of hollow-core microstructured fibers (HC-MFs), which paves the way for combing MRI and optical bioimaging. Our approach is based on layer-by-layer assembly of oppositely charged polyelectrolytes and magnetite nanoparticles on the inner core surface of HC-MFs. Incorporation of magnetite nanoparticles into polyelectrolyte layers renders HC-MFs visible for MRI and induces the red-shift in their transmission spectra. Specifically, the transmission shifts up to 60 nm have been revealed for the several-layers composite coating, along with the high-quality contrast of HC-MFs in MRI scans. Our results shed light on marrying fiber-based endoscopy with MRI to open novel possibilities for minimally invasive clinical diagnostics and surgical procedures in vivo.

show abstract

Blood typing using microstructured waveguide smart cuvette

Cited by 9 publications

References 8 publications

Sapphire Photonic Crystal Waveguides for Terahertz Sensing in Aggressive Environments

Sapphire Photonic Crystal Waveguides for Terahertz Sensing in Aggressive Environments

Functionalized Microstructured Optical Fibers: Materials, Methods, Applications

Enabling magnetic resonance imaging of hollow-core microstructured optical fibers via nanocomposite coating

Contact Info

Product

Resources

About