Blood transfusion services for patients with sickle cell disease in Nigeria

Diaku-Akinwumi, Ijeoma; Abubakar, Sani Bako; Adegoke, Samuel Ademola; Adeleke, SI; Adewoye, Oyebade; Adeyemo, T A; Akinbami, Akinsegun; Akinola, N. O.; Akinsulie, Adebola; Akinyoola, Adeline; Aneke, John C; Awwalu, Sani; Babadoko, Ahmadu Aliyu; Bj, Brown; Obuoha, Ejike; Emodi, IJ; George, I. O.; Girei, Ahmed; Hassan, Abdulaziz; Kangiwa, Garba U.; Lawal, Olubunmi Adeola; Mabogunje, Cecilia Abimbola; Madu, Anazoeze Jude; Mustapha, Akeem; Ndakotsu, Muhammad Alhaji; Nnodu, Obiageli; Nwaneri, DU; F, Friday Odey; Ohiaeri, Chinatu; Olaosebikan, Rasaq; Olatunya, Oladele Simeon; Oniyangi, Oluseyi; Opara, Hyginus; Ugwu, Ngozi Immaculata; Musa, A.A.; Abdullahi, Shehu U.; Abubakar, Usman; Utuk, Enobong; Jibir, Binta W.; Adekile, Adekunle

doi:10.1093/inthealth/ihw014

Cited by 22 publications

(22 citation statements)

References 19 publications

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“…Unfortunately, our study shows that only about a third of the haematologists will definitely commence exchange blood transfusion on patients "at risk" or those who have already developed stroke. This is similar to the findings of the study by Diaku-Akinwunmi, et al [18] also done across several Nigerian health facilities [18]. This shows a poor acceptance of the practice of EBT in our environment which is most likely due to challenges in availability of safe blood for transfusion in this environment as observed by Ahmed and his colleagues in a study conducted in Northern Nigeria [19] and also the financial burden on the patients and their relatives.…”

Section: Discussionsupporting

confidence: 88%

Physicians’ Opinion on the Practice of Exchange Blood Transfusion for Treatment of Stroke in Sickle Cell Anaemia

Madu¹

2018

HIJ

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Section: Discussionsupporting

confidence: 88%

Physicians’ Opinion on the Practice of Exchange Blood Transfusion for Treatment of Stroke in Sickle Cell Anaemia

Madu¹

2018

HIJ

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“…Globally, about 312,000 neonates are born with SCA annually and 75% of these births occur in Africa . Nigeria has the highest burden of SCA in the world . SCA is characterized by heterogeneous clinical phenotypes, and genetic modifiers play roles in the clinical presentation of the disease …”

Section: Introductionmentioning

confidence: 99%

Influence of alpha thalassemia on clinical and laboratory parameters among nigerian children with sickle cell anemia

Olatunya

Albuquerque

Adekile

et al. 2018

Clinical Laboratory Analysis

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“…16,17 Available evidence suggests that chronic blood transfusion therapy and automated RBC exchange are poorly available for SCD care in Nigeria. 18,19 In Nigeria, local studies have suggested o R i g i n a l R e p o R t Immune erythrocyte antibodies in adult patients with sickle cell disease and blood donors in Lagos, Nigeria: a comparative study A.S. Adewoyin, O.A. Daramola, A.A. Ogbenna, and T.A.…”

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confidence: 99%

Immune erythrocyte antibodies in adult patients with sickle cell disease and blood donors in Lagos, Nigeria: a comparative study

et al. 2021

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Sickle cell disease (SCD) poses a major public health challenge in sub-Saharan Africa, including Nigeria. Blood transfusion is a mainstay in SCD treatment. Erythrocyte alloimmunization is known to complicate the transfusional care of patients with SCD. Immune alloantibodies are associated with hemolytic transfusion reactions and transfusion refractoriness. We aimed to determine the prevalence, specificities, and clinical associations/ risk factors of immune erythrocyte alloantibodies among adult patients with SCD compared with healthy blood donors in Lagos, Nigeria, through a cross-sectional study. All participants were interviewed using a structured questionnaire to obtain details on bio-data, hemoglobin phenotype, blood transfusion history, and SCD history where relevant. Blood specimens obtained from each participant were subjected to antibody screening/identification using tube agglutination method. The mean age of the SCD participants and healthy blood donors was 27.92 and 29.04 years, respectively. The majority (72.5%) of the SCD participants had received at least 1 unit of red blood cell (RBC) transfusion in their lifetime, compared with only 7.5 percent of blood donors. Six SCD participants (7.5%) tested positive for atypical erythrocyte alloantibodies, with none among blood donors. Most of the antibodies (75%) belonged to the Rh blood group system. The most frequent antibody was anti-E, followed by anti-C and anti-D. Advancing age (30 years or more), recent transfusions (last 4 weeks), higher transfusion rates, and established renal disease were significantly associated with alloimmunization (p values of 0.026, 0.043, 0.002, and 0.043, respectively). This study suggests blood transfusion as a strong risk factor for RBC alloimmunization in SCD patients. Extended RBC phenotyping is recommended for all patients with SCD, especially those receiving regular transfusions.

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Blood transfusion services for patients with sickle cell disease in Nigeria

Cited by 22 publications

References 19 publications

Physicians’ Opinion on the Practice of Exchange Blood Transfusion for Treatment of Stroke in Sickle Cell Anaemia

Physicians’ Opinion on the Practice of Exchange Blood Transfusion for Treatment of Stroke in Sickle Cell Anaemia

Influence of alpha thalassemia on clinical and laboratory parameters among nigerian children with sickle cell anemia

Immune erythrocyte antibodies in adult patients with sickle cell disease and blood donors in Lagos, Nigeria: a comparative study

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