Blood transfusion-induced suppression of cellular immunity in man

Fischer, Ernst; Lenhard, V.; Seifert, Petra; Kluge, A.; Johannsen, R.

doi:10.1016/0198-8859(80)90013-0

Cited by 149 publications

(38 citation statements)

References 8 publications

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“…Homologous blood transfusions have some immunosuppressive effect (Fisher et al, 1980, George and Morello, 1986, Heiss et al, 1993, although the mechanisms have not yet been elucidated (Bordin et al, 1994). Lymphomas in transplanted patients under immunosuppressive treatment are generally of highgrade morphology and are often extranodal (Starzl et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

Blood transfusion as a risk factor for non-Hodgkin lymphoma

Brandt

Brandt²,

Olsson³

et al. 1996

Br J Cancer

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Summary In a case-control study of 280 out of 426 consecutive patients with a recent diagnosis of nonHodgkin lymphoma (NHL) and 1827 control subjects, 53 (19%) and 230 (13%) respectively had received blood transfusions 1 year or more before the interview. Using an age-and sex-stratified analysis the odds ratio (OR) for transfusion was 1.74 (95% CI 1.24-2.44). ORs were also determined for transfusions received in the intervals 1 -5, 6 -15, 16-25 and > , Carli et al., 1994, Cartwright et al., 1994, National Board of Health and Welfare, 1995. The causes of this increase are unknown, and in an attempt to identify risk factors for NHL a case-control study has been initiated in the Southern Health Care Region of Sweden.According to cohort studies of cancer morbidity in blood recipients, transfusions may be a risk factor for NHL. In a Swedish study (Blomberg et al., 1993) an excess of NHL was observed in previously transfused subjects, the standardised morbidity ratio being 4.09 (95% CI 1.65-8.43). Cerhan et al. (1993) obtained information about past transfusions from women aged 55-69 years who were resident in Iowa and followed up for 5 years. For women who had ever received a blood transfusion the relative risk of NHL was 2.20 (95% CI 1.35-3.58). Memon and Doll (1994) identified nearly 13 000 infants who received blood transfusions shortly after birth in England, Wales and Scotland and recorded the incidence of subsequent malignant tumours. The incidence of NHL at 15-49 years of age was about twice that expected, but the excess was not statistically significant.Our ongoing case-control study offered an opportunity to further evaluate the relation between previous blood transfusions and the development of NHL. We report here on the association between transfusions and NHL. The relation between the time lapse since transfusion and the risk of lymphoma has also been studied. Subjects and methods

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Section: Discussionmentioning

confidence: 99%

Blood transfusion as a risk factor for non-Hodgkin lymphoma

Brandt

Brandt²,

Olsson³

et al. 1996

Br J Cancer

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“…Before the advent of medical immunosuppression, intentional immunosuppression before organ transplantation was accomplished with scheduled RBC transfusions. 31 Research has since demonstrated that transfusion primes the immune system to excessively activate nonspecific proinflammatory cascades while decreasing the overall ability to mount an organized, effective defense to infection. [32][33][34][35][36] Transfusion has also been shown to increase rates of nosocomial infections, multiple system organ failure, acute lung injury and acute respiratory distress syndrome, and mortality.…”

Section: Discussionmentioning

confidence: 99%

A Predictive Model for Massive Transfusion in Combat Casualty Patients

McLaughlin

Niles

Salinas

et al. 2008

Journal of Trauma: Injury, Infection &Amp; Critical Care

190

159

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“…PPD, tetanus, mumps, vaccinia) after a single blood transfusion. This effect lasted for over two weeks (Fischer 1980). More profound and lasting depression was seen after a second transfusion given after 4 weeks.…”

Section: Nonspecific Immune Suppression After Transfusionmentioning

confidence: 88%