Blood-to-brain communication in aging and rejuvenation

Bieri, Gregor; Schroer, Adam B.; Villeda, Saul

doi:10.1038/s41593-022-01238-8

Cited by 40 publications

(46 citation statements)

References 158 publications

(241 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neurodegenerative diseases refer to a heterogeneous group of disorders in the central or peripheral nervous system, which commonly include Alzheimer's disease (AD), Parkinson's disease, schizophrenia, and others. [98,[203][204][205] Among these diseases, AD is a widely investigated neurodegenerative disease that accounts for 70% of all dementia and affects the quality of human life. [203][204][205] Early diagnosis of AD is of vital importance because there is no certain treatment after the lesion has progressed in the late stage.…”

Section: Neurodegenerative Diseasementioning

confidence: 99%

“…[98,[203][204][205] Among these diseases, AD is a widely investigated neurodegenerative disease that accounts for 70% of all dementia and affects the quality of human life. [203][204][205] Early diagnosis of AD is of vital importance because there is no certain treatment after the lesion has progressed in the late stage. [116,203] In 2020, Park et al demonstrated a dualantibody-modified GFET biosensor for multiplex detection of two AD biomarkers (Figure 11a).…”

Section: Neurodegenerative Diseasementioning

confidence: 99%

See 1 more Smart Citation

Graphene Transistors for In Vitro Detection of Health Biomarkers

Dai

Kong

Chen

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Biomarkers are primary indicators for precise diagnosis and treatment. The early identification of health biomarkers has been sustained by the evolutionary success in sensor technologies. Among them, graphene field-effect transistor (GFET) biosensors have exhibited major advantages such as an ultrashort response time, high sensitivity, easy operation, capability of integration, and label-free detection. Owing to the atomic thickness, graphene restricts charge carrier flow merely at the material surface and responds to foreign stimuli directly, leading to effective signal acquisition and transmission. Here, this review summarizes the latest advances in GFET biosensors in a comprehensive manner that contains the device design, working principle, surface functionalization, and proof-of-concept applications. It provides a comprehensive survey of GFET biosensors with regard to biomarker analysis at the single-device level and integrated prototypes that include wearable sensors, biomimetic systems, healthcare electronics, and diagnostic platforms. Moreover, there is discussion on the long-standing research efforts and outlook for the future development of GFET sensor systems from lab to fab.

show abstract

Section: Neurodegenerative Diseasementioning

confidence: 99%

Section: Neurodegenerative Diseasementioning

confidence: 99%

Graphene Transistors for In Vitro Detection of Health Biomarkers

Dai

Kong

Chen

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…Physical exercise leads to the release of many peripheral factors, including myokines from muscle, hepatokines from liver, and adipokines from adipose tissue (Cooper et al, 2018; Madhu et al, 2022). Studies using parabiosis have demonstrated that peripheral factors in the blood have significant regulatory roles on brain functions and behaviors (Bieri et al, 2023). As described below, among all the neurotrophic factors, brain‐derived neurotrophic factor (BDNF) exhibits the most substantial increase in the brain during voluntary running and is a well‐established positive regulator of adult neurogenesis (Farmer et al, 2004; Liu & Nusslock, 2018; Reichardt, 2006).…”

Section: Physical Exercisementioning

confidence: 99%

“…Voluntary F I G U R E 1 Factors that promote and inhibit adult hippocampal neurogenesis. The summary of negative factors that inhibit adult hippocampal neurogenesis (black) and positive factors that promote adult hippocampal neurogenesis (white) is based on extensive literature (see relevant reviews: Bieri et al, 2023;Cooper et al, 2018;Kempermann, 2022;Kempermann et al, 2015;Zocher & Toda, 2023).…”

Section: Physical Exercise and Peripheral Factors That Mediate Brain ...mentioning

confidence: 99%

Mechanisms underlying the effect of voluntary running on adult hippocampal neurogenesis

2023

View full text Add to dashboard Cite

Adult hippocampal neurogenesis is important for preserving learning and memoryrelated cognitive functions. Physical exercise, especially voluntary running, is one of the strongest stimuli to promote neurogenesis and has beneficial effects on cognitive functions. Voluntary running promotes exit of neural stem cells (NSCs) from the quiescent stage, proliferation of NSCs and progenitors, survival of newborn cells, morphological development of immature neuron, and integration of new neurons into the hippocampal circuitry. However, the detailed mechanisms driving these changes remain unclear. In this review, we will summarize current knowledge with respect to molecular mechanisms underlying voluntary running-induced neurogenesis, highlighting recent genome-wide gene expression analyses. In addition, we will discuss new approaches and future directions for dissecting the complex cellular mechanisms driving change in adult-born new neurons in response to physical exercise.

show abstract

“…The levels of CCL11 are increased with aging in both humans and mice, and CCL11 is associated with impaired cerebral function, including learning and memory [ 15 , 22 , 28 , 29 , 30 ]. CCL11 rapidly crosses the blood–brain barrier (BBB), suggesting that blood-borne CCL11 may directly affect the brain [ 20 , 31 ] and cognitive decline [ 14 , 15 , 16 , 17 , 20 , 31 ]. The CCL11-main receptor is C-C chemokine receptor 3 (CCR3), which is highly expressed by microglia and hippocampal neurons [ 12 , 13 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Young Astrocytic Mitochondria Attenuate the Elevated Level of CCL11 in the Aged Mice, Contributing to Cognitive Function Improvement

Tashiro

Ozaki

Bautista-Garrido

et al. 2023

IJMS

View full text Add to dashboard Cite

Aging drives cognitive decline, and mitochondrial dysfunction is a hallmark of age-induced neurodegeneration. Recently, we demonstrated that astrocytes secrete functional mitochondria (Mt), which help adjacent cells to resist damage and promote repair after neurological injuries. However, the relationship between age-dependent changes in astrocytic Mt function and cognitive decline remains poorly understood. Here, we established that aged astrocytes secret less functional Mt compared to young astrocytes. We found the aging factor C-C motif chemokine 11 (CCL11) is elevated in the hippocampus of aged mice, and that its level is reduced upon systemic administration of young Mt, in vivo. Aged mice receiving young Mt, but not aged Mt improved cognitive function and hippocampal integrity. Using a CCL11-induced aging-like model in vitro, we found that astrocytic Mt protect hippocampal neurons and enhance a regenerative environment through upregulating synaptogenesis-related gene expression and anti-oxidants that were suppressed by CCL11. Moreover, the inhibition of CCL11-specific receptor C-C chemokine receptor 3 (CCR3) boosted the expression of synaptogenesis-related genes in the cultured hippocampal neurons and restored the neurite outgrowth. This study suggests that young astrocytic Mt can preserve cognitive function in the CCL11-mediated aging brain by promoting neuronal survival and neuroplasticity in the hippocampus.

show abstract

Blood-to-brain communication in aging and rejuvenation

Cited by 40 publications

References 158 publications

Graphene Transistors for In Vitro Detection of Health Biomarkers

Graphene Transistors for In Vitro Detection of Health Biomarkers

Mechanisms underlying the effect of voluntary running on adult hippocampal neurogenesis

Young Astrocytic Mitochondria Attenuate the Elevated Level of CCL11 in the Aged Mice, Contributing to Cognitive Function Improvement

Contact Info

Product

Resources

About