This paper reports the findings from our preliminary investigation into the blood supply chain in Indonesia. The aim is to obtain factors influencing blood safety and availability, and ultimately to better understand its dynamics. A single embedded case study was adopted as a research design. Data were collected using six semi-structured interviews, walkthroughs, and written documents available from a blood centre and four associated hospitals in Yogyakarta. Template and within-case analyses were then used to analyse the data and, subsequently, to identify and categorise themes emerging from the data. Governmental and organisational policies, costs, donor management, stock management, and facilities are the main factors emerging from the data. These factors are interrelated and, collectively, they influence blood safety and availability across the blood supply chain.