Blood Sugar Time Curves Following the Ingestion of Dihydroxyacetone

Rabinowitch, I. M.; Frith, Althea B.; Bazin, Eleanor V.

doi:10.1016/s0021-9258(18)84871-2

Cited by 14 publications

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“…As mentioned above, DHA is primarily used as an ingredient in sunless tanning products, although minor uses are reported in various other fields ( Figure 4 ). It has been evaluated as a potential medicine for several diseases: for children with glycogen storage disease (diabetes) [ 14 , 17 , 23 , 24 , 25 , 26 ]; as a complementary photoprotector for patients suffering from various porphyric diseases, which are liver disorders leading notably to increased skin photosensitivity [ 27 , 28 ]; as an antifungal agent to cure dermatomycosis afflictions [ 29 , 30 ]; or as a symptomatic treatment for psoriasis [ 31 ] and vitiligo, a skin disorder resulting in the appearance of depigmented stains on the skin of affected patients [ 13 , 16 , 28 , 32 ]. DHA is also used as an important feedstock for the production of a range of industrially important chemicals, such as 1,2-propylene glycol, lactic acid, methotrexate, DL-serine and various surfactants [ 30 , 33 , 34 , 35 , 36 ].…”

Section: An Overview Of Dha From Key Metabolite To Sunless Tanningmentioning

confidence: 99%

Dihydroxyacetone: A User Guide for a Challenging Bio-Based Synthon

et al. 2023

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1,3-dihydroxyacetone (DHA) is an underrated bio-based synthon, with a broad range of reactivities. It is produced for the revalorization of glycerol, a major side-product of the growing biodiesel industry. The overwhelming majority of DHA produced worldwide is intended for application as a self-tanning agent in cosmetic formulations. This review provides an overview of the discovery, physical and chemical properties of DHA, and of its industrial production routes from glycerol. Microbial fermentation is the only industrial-scaled route but advances in electrooxidation and aerobic oxidation are also reported. This review focuses on the plurality of reactivities of DHA to help chemists interested in bio-based building blocks see the potential of DHA for this application. The handling of DHA is delicate as it can undergo dimerization as well as isomerization reactions in aqueous solutions at room temperature. DHA can also be involved in further side-reactions, yielding original side-products, as well as compounds of interest. If this peculiar reactivity was harnessed, DHA could help address current sustainability challenges encountered in the synthesis of speciality polymers, ranging from biocompatible polymers to innovative polymers with cutting-edge properties and improved biodegradability.

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Section: An Overview Of Dha From Key Metabolite To Sunless Tanningmentioning

confidence: 99%

Dihydroxyacetone: A User Guide for a Challenging Bio-Based Synthon

et al. 2023

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“…The awareness of DHA, sometimes called “dioxyacetone,” in carbohydrate metabolism dates back to the early 1900s. , One of the first proposed therapeutic applications of DHA was for the treatment of diabetes. Rabinowitch published reports on the ability of DHA to reduce the dosage of insulin needed by diabetics. ,− It was not until the late 1950s, however, that DHA gained interest for its first major commercial use: sunless tanning lotions. Eva Wittgenstein noticed that when children accidentally “spit up” an orally administered solution of DHA onto their skin, pigmentation occurred .…”

Section: Dihydroxyacetone Synthonsmentioning

confidence: 99%

Synthetic Biomaterials from Metabolically Derived Synthons

et al. 2016

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The utility of metabolic synthons as the building blocks for new biomaterials is based on the early application and success of hydroxy acid based polyesters as degradable sutures and controlled drug delivery matrices. The sheer number of potential monomers derived from the metabolome (e.g., lactic acid, dihydroxyacetone, glycerol, fumarate) gives rise to almost limitless biomaterial structural possibilities, functionality, and performance characteristics, as well as opportunities for the synthesis of new polymers. This review describes recent advances in new chemistries, as well as the inventive use of traditional chemistries, toward the design and synthesis of new polymers. Specific polymeric biomaterials can be prepared for use in varied medical applications (e.g., drug delivery, tissue engineering, wound repair, etc.) through judicious selection of the monomer and backbone linkage.

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Glykoside

Zemplén¹

1931

Biochemisches Handlexikon

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Blood Sugar Time Curves Following the Ingestion of Dihydroxyacetone

Cited by 14 publications

References 0 publications

Dihydroxyacetone: A User Guide for a Challenging Bio-Based Synthon

Dihydroxyacetone: A User Guide for a Challenging Bio-Based Synthon

Synthetic Biomaterials from Metabolically Derived Synthons

Glykoside

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