Blood Sugar Lowering Effect of<i>Coccinia grandis</i>(L.) J. Voigt: Path for a New Drug for Diabetes Mellitus

Munasinghe, M. A. A. K.; Abeysena, Chrishantha; Yaddehige, I. S.; Vidanapathirana, T.; Piyumal, K. P. B.

doi:10.1155/2011/978762

Cited by 38 publications

(24 citation statements)

References 6 publications

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“…The increased incidence of hypoglycaemic symptoms may be a direct action of the herbal remedies or a potentiation of the hypoglycaemic effect of the conventional medicine. Hypoglycaemic effect of both bitter gourd and ivy gourd has been studied in humans and bitter gourd may possess an acute hypoglycaemic effect following ingestion [ 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

Use of Complementary and Alternative Medicines (CAMs) among type 2 diabetes patients in Sri Lanka: a cross sectional survey

Medagama

Bandara

Abeysekera

et al. 2014

BMC Complement Altern Med

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BackgroundThe incidence of chronic illnesses has increased worldwide. Diabetes is one such illness and 80% of the diabetic population lives in the developing world. There is a rapidly growing trend towards the use of Complementary and Alternative Medical practices in Diabetes. Sri Lanka is a developing Asian nation with a rich culture of Ayurvedic and native medical culture.The objective of this study was to find the prevalence of use of CAMs in a diabetic population attending a large multiethnic diabetes facility in a University unit and to assess whether there is an increase in the incidence of hypoglycaemic episodes among users of CAMs.MethodsA cross sectional study was performed at Teaching Hospital Peradeniya between April and August 2012. Following verbal consent, 254 type 2 adult diabetic patients attending the diabetes facility were interviewed regarding the use of CAM and hypoglycaemia using an interviewer-administered questionnaire.ResultsOf the 252 valid results, 192 patients (76%) admitted to the use of a CAM to reduce blood glucose. Bitter gourd, ivy gourd and crepe ginger were used by 128, 113 and 92 individuals. While 19% used a single agent, 34%, 21% and 2.4% used 2,3 and more than 3 agents. The incidence of hypoglycaemia in CAM users was 21% and 16.6% in non-users. The difference was statistically not significant. (p = 0.57) Ingestion of Costus speciosus (Crepe ginger) was associated with higher incidence of hypoglycaemia (P = 0.01).Female gender was significantly associated with CAM use (p = 0.01), while the age, duration of diabetes, presence of co-morbidities and complications of diabetes failed to show a significant association.ConclusionSri Lanka has a very high use of herbal supplementation in type 2 diabetes patients. Although the overall incidence of hypoglycaemia is not increased among CAM users, crepe ginger is associated with significant hypoglycaemia and warrants further research.Electronic supplementary materialThe online version of this article (doi:10.1186/1472-6882-14-374) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Use of Complementary and Alternative Medicines (CAMs) among type 2 diabetes patients in Sri Lanka: a cross sectional survey

Medagama

Bandara

Abeysekera

et al. 2014

BMC Complement Altern Med

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“…[F: Cucurbitacea] Coccinia grandis (EN: Ivy gourd, MN: Timun tikus, SN: Tam loeng) is climber plant that produces white flowers and fruits which are green when young that turns red when ripe The plant is highly valued for its medicinal value in treating diabetic patient [18].…”

Section: Resultsmentioning

confidence: 99%

Diversity of Plants Species Abundantly Consumed In Traditional Practice of Siamese Community of Kelantan, Malaysia

Rak¹,

Tharmadurai²,

Khanam³

et al. 2019

Proceedings of the Proceedings of the 2nd International Conference on Advance and Scientific Innovation, ICASI 2019, 18 July, B

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Siamese community in Kelantan are more health conscious by taking plants with medicinal value as daily dietary intake but type of plants and its traditional use yet to be explore and recorded. The objective is to identify and document plants and plant parts those are being consumed and the traditional uses. Plants that are being consumed by Siamese community in three main localities were recorded by a verbal interview with old folks of the village. Plants were collected with the guide of the old folks for identification. From the identified names, further information was collected through literature reviewed on their recorded medicinal values. A total of 20 plants were collected, identified and reported. The plants belong to 16 families. The list of plants recorded serves as a datasheet for the study of plants with medicinal value consumed by Siamese community of Kelantan.

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“…There are some studies that suggest a high potential for the use of Coccinia grandis leaf extracts in diabetes treatment (Azad Khan et al 1980; Kuriyan et al 2008; Munasinghe et al 2011). Parts of the observed effects are explained by inhibition of gluconeogenesis in the liver due to repression of glucose-6-phosphatase (Hossain et al 1992) and fructose-1,6-bisphosphatase (Shibib et al 1993).…”

Section: Plant – Biotic Environment Interactionsmentioning

confidence: 99%

Monograph of Coccinia (Cucurbitaceae)

Holstein¹

2015

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This monograph deals with all 95 names described in the Cucurbitaceae genus Coccinia and recognizes 25 species. Taxonomic novelties are Coccinia adoensis var. aurantiaca (C.Jeffrey) Holstein, stat. nov., Coccinia sessilifolia var. variifolia (A.Meeuse) Holstein, stat. nov., and Coccinia adoensis var. jeffreyana Holstein, var. nov. For the 25 species 3157 collections were examined, of which 2024 were georeferenced to produce distribution maps. All species are distributed in sub-Saharan Africa with one species, Coccinia grandis, extending from Senegal in West Africa east to Indonesia and being naturalized on Pacific Islands, in Australia, the Caribbean, and South America. Coccinia species are dioecious creepers or climbers with simple or bifid tendrils that occupy a range of habitats from arid scrubland, woodlands to lowland rainforest and mist forest. The corolla of Coccinia species is sympetalous, usually pale yellow to orange, and 1 to 4.5 cm long. Pollination is by bees foraging for pollen or nectar. After pollination, the developing ovary often exhibits longitudinal mottling, which usually disappears during maturation. All species produce berries with a pericarp in reddish colors (orange-red through to scarlet red), hence the generic name. The globose to cylindrical fruits contain numerous grayish-beige flat to lenticular seeds. Chromosome numbers are 2n = 20, 24, and 22 + XX/XY. Many Coccinia species are used for food, either as roasted tubers, greens as spinach, or the fruits as vegetables. Medicinal value is established in Coccinia grandis, of which leaves and sap are used against diabetes.

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Blood Sugar Lowering Effect ofCoccinia grandis(L.) J. Voigt: Path for a New Drug for Diabetes Mellitus

Cited by 38 publications

References 6 publications

Use of Complementary and Alternative Medicines (CAMs) among type 2 diabetes patients in Sri Lanka: a cross sectional survey

Use of Complementary and Alternative Medicines (CAMs) among type 2 diabetes patients in Sri Lanka: a cross sectional survey

Diversity of Plants Species Abundantly Consumed In Traditional Practice of Siamese Community of Kelantan, Malaysia

Monograph of Coccinia (Cucurbitaceae)

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