Blood sugar lowering effect of Vernonia amygdalina Del, in an experimental rabbit model

Akah, Peter A.; Okafor, CO

doi:10.1002/ptr.2650060318

Cited by 148 publications

(125 citation statements)

References 8 publications

Supporting

Mentioning

112

Contrasting

Order By: Relevance

“…), immunomodulatory (Akah and Okafor, 1992), lipidlowering effects of V. amygdalina leaf extract obtained in various studies.…”

Section: Resultsmentioning

confidence: 99%

Excess Body Fat Elimination (Anti-Obesity) Effects of Vernonia Amygdalina Leaf Extract

Anastasi¹

2011

American Journal of Pharmacology and Toxicology

View full text Add to dashboard Cite

Problem statement: Many obese or overweight persons complain that they don't know what makes them fat. They would also like to know how to loss excess fat and maintain the fat loss. Approach: This research study was structured to make the obesed subject loose excess fat and at the same time learn what makes people fat so that in the future they would prevent developing obesity by eating proper diets. Results: Thirty nine obese human subjects took Vernonia amygdalina leaf extract orally for one month. The subjects were required to adhere to dietary restrictions during the treatment period. The dietary restrictions included abstaining from fattening foods, soups and stews or gravy; acidic beverages; soft drinks; acidic/spicy foods, soups, stews, drinks; artificial seasoning; alcohol; tobacco and consumption of large quantities of carbohydrates. Thirty seven of the subjects who obeyed the dietary restrictions lost 16 kg of excess body fat in one month. One of the subjects who also adhered to the dietary restrictions of the treatment lost 15 kg of excess body fat. The subject who kept all the dietary restrictions except the consumption of alcohol and the consumption of two thirds of formerly consumed carbohydrates; lost 10 kg of excess body fat. These results show that V. amygdalina leaf has specific and efficacious excess body fat elimination (anti-obesity) properties. Conclusion:The results of the study enable us to conclude that the excess fat elimination effects of V. amygdalina leaf extract can be antagonized by consumption of excess calories like those provided by alcohol, the consumption of acidic foods and drinks. The consumption of three thirds leafy vegetable equivalent of a certain amount of carbohydrates together with required daily amounts of proteins, minerals, vitamins and water enables one to avoid accumulation of excess body fat.

show abstract

“…), immunomodulatory (Akah and Okafor, 1992), lipidlowering effects of V. amygdalina leaf extract obtained in various studies.…”

Section: Resultsmentioning

confidence: 99%

Excess Body Fat Elimination (Anti-Obesity) Effects of Vernonia Amygdalina Leaf Extract

Anastasi¹

2011

American Journal of Pharmacology and Toxicology

View full text Add to dashboard Cite

show abstract

“…There are reports concerning the hypoglycaemic, antineoplastic antibacterial and antioxidant properties of the plant. (Akah et al, 1992;Izevbigie et al, 2004;Taiwo et al, 1999;Iwalewa et al, 2005). Despite the varied uses of the plant, there are no information on its analgesic properties and exact toxicology on sub-chronic exposure, although some reports describe its antiplasmodial effects (Abosi et al 2005;Masaba et al 2000;Tona et al, 2004;Wilcox et al, 1999).…”

Section: Wwwintechopencommentioning

confidence: 99%

Herbal Medicine in the Treatment of Malaria: Vernonia amygdalina: An Overview of Evidence and Pharmacology

Njan¹

2012

Toxicity and Drug Testing

View full text Add to dashboard Cite

“…It has been scientifically documented that the roots of the plant has been used as toothache and gingivitis as a result of its proven antimicrobial activity [12]. V. amygdalina plant has been researched upon and the experimental evidence for its use in diabetes management as reported by Udoamaka [13] included; 80 mg/kg aqueous extract of the leaves produced a dose dependent decrease in blood glucose levels in normal and alloxan-induced diabetic rabbits [14]; chronic intake of 400mg/kg ethanolic extract of the fresh leaves significantly decreased fasting blood glucose levels, increased serum and pancreatic insulin levels, increased the activity of liver antioxidant enzymes as well as increased the expression and distribution of Glut 4 receptors in STZ-induced diabetic rats [15]; 150ml of a (1:1:1) decoction mix of the leaves of Vernonia amygdalina, Ocimum gratissimum and Gongronema latifolium decreased baseline blood glucose levels in normal subjects when preadministered to normal subjects 45 minutes before an OGTT [16], however the selected plant has not been evaluated simultaneously for its potent inhibition of α-and β-glucosidases, maltase glucoamylase, aldose reductase (ALR1 and ALR2) and identifying the bioactive compounds of the chloroform crude extract.…”

Section: Introductionmentioning

confidence: 99%

Characterization and Evaluation of Vernonia amygdalina Extracts for its Antidiabetic Potentials

E¹,

A²,

O.T³

et al. 2018

ijSciences

View full text Add to dashboard Cite

Abstract:Background: There is increase in the demand for the use of medicinal plants for the treatment of various ailments such as cancer, hypertension and diabetes locally as a result of the inability of the synthesized drugs to completely eradicate the ailments and also with the attendant side effects attached to the use of drugs. Objective: The aim of this research work was to investigate the Aldose reductase, α-glucosidase, β -glucosidase and maltase glucoamylase inhibitory potential of the crude extracts of Vernonia amygdalina, and characterizing the extracts. Materials and method:The leaves of the plant was obtained, air dried and turned to powdered form using commercial grinding machine with dimension 34×38×75. The extracted crudes were subjected into in-vitro studies of the inhibitory potentials using recommended protocols. The IC 50 values were calculated using Graph pad prism 5.0 software and the identified compounds were screened for drug properties using ONLINE OSIRIS server explorer. Results: The (IC 50 0.6 ± 0.03 μg/mL) of the chloroform extract was better than the methanolic extract of IC 50 (1.532±0.63μg/mL) and the results were better than the acarbose standard (IC 50 234.6 + 2.01μM). The maltase glucoamylase inhibitory potentials of the chloroform and methanolic extracts in the range of IC 50 1.112 ± 0.90 μg/mL and 1.315 ± 0.7 μg/mL. The β-glucosidase screening of the extracts results indicated that they do not have good selective inhibitor properties. IC 50 of Aldose reductase (ALR2) of chloroform extract IC 50 (1.339+0.264μg/mL) was better than that of methanolic extract of IC 50 (1.437+0.6μg/mL) and these values were better when compared with the standard, sorbinil of IC 50 (3.10 +0.20μM).The aldehyde reductase (ALR1) of methanolic extract IC 50 (0.325+0.02μg/mL) was better than that of chloroform extract of IC 50 (0.964+0.16μg/mL) and when compared with standard 10mM vaproic acid IC 50 (57.4 +10μM).The GC-MS of the chloroform extract revealed compounds which were screened computationally to for various drug properties such as drug likeness, cLogS, cLogP, H-bond acceptor and H-bond Donor. Conclusion: The promising inhibitory potential of the plant extracts and characterization of the extract is an indication of the usefulness of the plant for the treatment of diabetes.

show abstract

Blood sugar lowering effect of Vernonia amygdalina Del, in an experimental rabbit model

Cited by 148 publications

References 8 publications

Excess Body Fat Elimination (Anti-Obesity) Effects of <i>Vernonia Amygdalina</i> Leaf Extract

Excess Body Fat Elimination (Anti-Obesity) Effects of <i>Vernonia Amygdalina</i> Leaf Extract

Herbal Medicine in the Treatment of Malaria: Vernonia amygdalina: An Overview of Evidence and Pharmacology

Characterization and Evaluation of Vernonia amygdalina Extracts for its Antidiabetic Potentials

Contact Info

Product

Resources

About