Blood stream infections caused by Acinetobacter baumannii group in Japan – Epidemiological and clinical investigation

Fujikura, Yuji; Yûki, Atsushi; Hamamoto, Takaaki; Kawana, Akihiko; Ohkusu, Kiyofumi; Matsumoto, Tetsuya

doi:10.1016/j.jiac.2016.02.006

Cited by 11 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Despite high prevalence of CRAB in China, the impact of carbapenem resistance on A. baumannii bacteremia has not been well documented. In this study, the crude and 30-day in-hospital mortality rate of nosocomial A. baumannii bacteremia were 21.2% and 12.7%, respectively, which are similar to the results of a five-year Japanese study [ 17 ], but relatively lower than other previous reports with high mortality rates from 29% to 63.5% [ 12 , 18 , 19 ]. This inconsistency is probably ascribed to the heterogeneity of epidemiology, the severity of diseases and the virulence factors of microbes.…”

Section: Discussionsupporting

confidence: 87%

Determinants of Mortality in Patients with Nosocomial Acinetobacter baumannii Bacteremia in Southwest China: A Five-Year Case-Control Study

Jin

et al. 2018

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

Purpose This study was aimed to identify the determinants of in-hospital mortality in Acinetobacter baumannii (A. baumannii) bacteremia and to assess impact of carbapenem resistance on mortality. Methods A five-year case-control study was conducted from January 2011 to December 2015 in a tertiary teaching hospital with 3200 beds, Southwest China. Clinical outcomes and potential determinants of mortality in patients with nosocomial A. baumannii bacteremia and carbapenem-resistant A. baumannii (CRAB) bacteremia were evaluated using Cox and logistic regression analyses. Results A total of 118 patients with nosocomial A. baumannii bacteremia were included. Seventy-one percent (84/118) of them had carbapenem-resistant A. baumannii (CRAB) bacteremia. The in-hospital mortality of nosocomial A. baumannii bacteremia was 21.2%, and the attributable in-hospital mortality rate due to CRAB was 21.5%. Significant difference of 30-day in-hospital mortality in the Kaplan–Meier curves was found between CRAB and CSAB groups (log-rank test, P=0.025). The Cox regression analysis showed that patients with CRAB bacteremia had 2.72 times higher risk for 30-day in-hospital mortality than did those with carbapenem-susceptible A. baumannii (CSAB) bacteremia (95% confidence intervals (CIs) 1.14–6.61, P=0.016). The logistic regression analysis reported that mechanical ventilation and respiratory tract as origin of bacteremia were independent predictors of mortality among patients with nosocomial A. baumannii bacteremia and CRAB bacteremia, while high APACHE II score on the day of bacteremia and multiple organ dysfunction syndromes (MODS) during hospitalization were independent predictors of mortality among patients with nosocomial A. baumannii bacteremia but not CRAB bacteremia. Conclusion It was the severity of illness (high APACHE II score and MODS) not carbapenem resistance that highlighted the mortality of patients with nosocomial A. baumannii bacteremia. The impact of mechanical ventilation on mortality suggested that respiratory dysfunction might prime the poor outcome. Protection of respiratory function during the progression of nosocomial A. baumannii bacteremia should be given more importance. Early identification and intervention of patients with nosocomial A. baumannii bacteremia in critical ill conditions were advocated.

show abstract

Section: Discussionsupporting

confidence: 87%

Determinants of Mortality in Patients with Nosocomial Acinetobacter baumannii Bacteremia in Southwest China: A Five-Year Case-Control Study

Jin

et al. 2018

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

show abstract

“…As amostras foram distribuídas nos grupos G1, G2, G4, G5, G8, G12, G13 e G14, além de 18 isolados não classificados (NC), apresentando perfis não descritos (Karah et al, 2012 . nosocomialis, A. pittii, A. ursingii e A. bereziniae (Fujikura et al, 2016;Lee et al 2015b;Wisplinghoff et al, 2012) como agentes etiológicos de infecções de corrente sanguínea. Embora seja reconhecido que espécies não-baumannii sejam também causadoras de IRAS,…”

Section: Teste De Susceptibilidade Antimicrobiana Por Disco-difusãounclassified

Caracterização genética e perfil de sensibilidade antimicrobiana de cepas multirresistentes de Acinetobacter baumannii presentes em um hospital de ensino

Tavares¹

View full text Add to dashboard Cite

, que são meu refúgio, minha fonte de energia e personificações do amor em meio às atribulações. AGRADECIMENTOSA Deus e ao plano espiritual, acima de tudo e por tudo.Aos meus avós Ioni e Mário, por todo o suporte, carinho e pela compreensão durante todos esses anos. Sem vocês por perto eu não teria chegado até aqui! Aos meus pais Rosa Maria e Paulo, por sempre terem me provido do necessário e de ainda muito mais a fim de que eu conquistasse todos os objetivos da minha vida e realizasse cada sonho meu. Pelo amor, apoio e carinho incondicionais. Por terem acreditado, assim como eu, que eu poderia chegar até aqui. Não há nada na minha vida que não seja graças a vocês.À minha irmã Ísis por todo o amor, toda a amizade e cumplicidade. Você é a certeza e o conforto de que jamais estarei só nessa grande viagem.A toda a minha família, por ser tão presente e prestativa. Cada telefonema, cada visita, conversa e convite alegram meus dias.Às minhas amigas Ana Paula Cassiolato, Juliana Failde, Juliana Pinhata, Natália Fernandes, Nathamy Fernanda e, especialmente, Gabriela Francisco e Maria Fernanda Bueno por todo auxílio profissional, pessoal e pela nossa amizade que transcende a pós-graduação.Aos amigos Viviane Santana, Cristiane Pinho, Muriel Cestari e Eugênio Telles por todo o apoio e compreensão sempre.Às amigas Fracotes Ana Maria Ruocco, Fernanda Helena Palermo, Juliana Stahl Pinto, Marília Quinalha e Suyen Safuan Naide, irmãs que a vida me deu. É maravilhoso poder acompanhar a evolução e os desdobramentos do caminho de cada uma. Vocês são parte de quem eu sou hoje.Aos amigos Gabriela Fonseca, Letícia Oliveira e Marcelo Corral por terem me recebido tão calorosamente no programa de pós-graduação, dandome a oportunidade de participar ativamente do programa e, principalmente, por toda a ajuda e amizade.Aos companheiros Sérgio Bokermann, Vanda Eliana Garcia Brandolim, Izilda Penha Rodrigues Zuba, Djalma Zuba e todo o Grupo de Amigos, por terem me devolvido tantas vezes ao eixo e me ensinado a ter calma e paciência -ou, ao menos, tentado.Ao meu orientador Carlos Henrique Camargo, pela oportunidade concedida, pelos ensinamentos transmitidos e pela grande inspiração. Por ter acreditado no meu potencial e me dado espaço para crescer, me desenvolver e me descobrir. . ursingii, A. variabilis, A. gyllenbergii (n=1, 0.9% each) and Acinetobacter spp (n=2; 1.7%). A. baumannii isolates were submitted to multiplex PCR for other oxacillinases and ISAba1 detection, antimicrobial susceptibility testing, molecular typing by pulsed field gel electrophoresis (PFGE), trilocus sequence typing (3LST) and multilocus sequence typing (MLST). blaOXA-23-like gene was detected in 105 isolates (92.1%), of which 100% were associated with ISAba1; blaOXA-72 was present in one isolate (0.9%) and blaOXA-231, in two isolates (1.7%). The majority (n=66; 57.9%) of isolates were classified as extensively resistant (XDR). The PFGE grouped the isolates into 11 clusters (A-K) and MLST identified the isolates belonging mainly to CC79 (42.4%), CC1 (16.6%), CC15 (...

show abstract

Enhanced bacterial killing with colistin/sulbactam combination against carbapenem-resistant Acinetobacter baumannii

Bian

Liu

Feng

et al. 2021

International Journal of Antimicrobial Agents

View full text Add to dashboard Cite

Blood stream infections caused by Acinetobacter baumannii group in Japan – Epidemiological and clinical investigation

Cited by 11 publications

References 38 publications

Determinants of Mortality in Patients with Nosocomial Acinetobacter baumannii Bacteremia in Southwest China: A Five-Year Case-Control Study

Determinants of Mortality in Patients with Nosocomial Acinetobacter baumannii Bacteremia in Southwest China: A Five-Year Case-Control Study

Caracterização genética e perfil de sensibilidade antimicrobiana de cepas multirresistentes de Acinetobacter baumannii presentes em um hospital de ensino

Enhanced bacterial killing with colistin/sulbactam combination against carbapenem-resistant Acinetobacter baumannii

Contact Info

Product

Resources

About