Abstract:We have developed a strategy to exploit the ERAD pathway for induction of specific degradation of the viral envelope E protein using novel recombinant fusion proteins called degradins. These molecules are formed by an N terminal moiety with target specific binding activity and a SEL1L moiety, which effectively targets the protein to ERAD.Results: The screening of a VHH based phage-display library identified DENV2 and ZIKV specific antibodies which recognize E protein within the ER, both as secretory and membra… Show more
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