Blood steroid levels predict survival in endometrial cancer and reflect tumor estrogen signaling

Forsse, David; Tangen, Ingvild L.; Fasmer, Kristine Eldevik; Halle, Mari K.; Viste, Kristin; Almås, Bjørg; Bertelsen, Bjørn-Erik; Trovik, Jone; Haldorsen, Ingfrid S.; Krakstad, Camilla

doi:10.1016/j.ygyno.2019.11.123

Cited by 11 publications

(12 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 30 Another research demonstrated that total TAT, VAT, and SAT were all related to plasma levels of estrone and estradiol, but not with VAT ratios. 31 Among the 115 cases of EC in this study, the differences in clinicopathologic features between the patients with high SAT lied in increased PR expression. This is consistent with another research by Mauland et al 32 : by analyzing the distribution of abdominal adipose tissue in 170 patients with EC, these researchers found that an increase in abdominal SAT volume was related to positive PR expression.…”

Section: Discussionmentioning

confidence: 79%

Association Between Abdominal Adipose Tissue Distribution and Risk of Endometrial Cancer: A Case-Control Study

Cheng

Wang

Jia

et al. 2022

Clin Med Insights Oncol

View full text Add to dashboard Cite

Background: Obesity contributes to endometrial cancer (EC). However, it is not clear whether the distribution of adipose tissue affects the occurrence of endometrial carcinoma. This study aimed to evaluate the relationship between abdominal adipose tissue distribution and EC. Methods: We designed a case-control study with 115 women with EC and a control group. The total abdominal adipose tissue, visceral adipose tissue, and subcutaneous adipose tissue were measured by single slice computerized tomography at the level of umbilicus. Univariate and multivariate logistic regression models were used to calculate odds ratios (ORs) for the risk of EC associated with adipose tissue distribution. Furthermore, we analyzed the correlation between adipose tissue distribution and clinicopathologic features of endometrial carcinoma. Results: Multivariate analysis showed that a larger visceral adipose tissue ratio was associated with an increased risk of EC after adjusting for body mass index (BMI) and diabetes (OR = 1.046, 95% confidence interval = [1.008-1.079]). The ratio of International Federation of Obstetrics and Gynecology (FIGO) stage I and type I EC was higher in EC patients with larger visceral adipose tissue (84.5% vs 63.2%, P = .009; 91.4% vs 75.4%, P = .021). There was a higher positive ratio of progesterone receptor in EC patients with a larger subcutaneous adipose tissue area (91.2% vs 77.6%; P = .044). Conclusions: Higher visceral adipose tissue ratio, independent of BMI, was associated with an increased risk of EC. Therefore, this study demonstrated that women with normal BMI, but abnormal abdominal adipose tissue distribution, have an increased risk for EC.

show abstract

Section: Discussionmentioning

confidence: 79%

Association Between Abdominal Adipose Tissue Distribution and Risk of Endometrial Cancer: A Case-Control Study

Cheng

Wang

Jia

et al. 2022

Clin Med Insights Oncol

View full text Add to dashboard Cite

show abstract

“…biopsy in combination with the preoperative ultrasound image available. However, these preoperative data are often inconsistent with the postoperative data 26 , indicating the need for the emergence of alternatives that increase the accuracy of the prognosis and diagnosis of this disease without adversely affecting the patients.…”

Section: Discussionmentioning

confidence: 99%

Association of laboratorial parameters and prognostic factors in uterine corpus cancer

Bezerra

Martins-Filho

Sousa

et al. 2021

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

OBJECTIVE:The aims were to compare the red blood cells, platelet count, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, red cell distribution width, and fasting glucose in peripheral blood of patients with benign and malignant uterine neoplasms and to relate these laboratory parameters with prognostic factors and overall survival in cancer. METHODS:The results of the laboratory parameters were analyzed using the Mann-Whitney U test. Receiver operating characteristic curves were used to find the cutoff values. Overall survival was estimated using the Kaplan-Meyer method.RESULTS: Higher values of neutrophil-lymphocyte ratio and fasting glucose were found in cancer patients. Higher platelet-lymphocyte ratio values were associated with other subtypes when compared with endometrioid subtype; higher values of red cell distribution width were found in stage II/IV when compared with stage I; lower hemoglobin values were related to stage II/IV and nonendometrioid histological type. Platelet-lymphocyte ratio <145.56 was associated with longer overall survival.CONCLUSION: Hemoglobin and platelet-lymphocyte ratio values are prognostic factors in uterine corpus cancer.

show abstract

“…Yet, steroids might serve as good predictors in diseases such as endometriosis or ovarian cancer: LC-MS applied to ectopic lesions revealed a specific pattern for P4 and testosterone (T) compared to serum [14]. In endometrial cancer, blood steroid levels predict survival in endometrial cancer and reflect tumor estrogen signaling [15]. In ovarian cancer, steroid hormone synthesis by the ovarian stroma surrounding epithelial ovarian tumors may participate in ovarian tumorigenesis [16].…”

Section: Introductionmentioning

confidence: 99%

“…In ovarian cancer, steroid hormone synthesis by the ovarian stroma surrounding epithelial ovarian tumors may participate in ovarian tumorigenesis [16]. Circulating 17α-hydroxyprogesterone (17OHP4) and 11-deoxycortisol (S) have been suggested as prognostic markers for endometrial cancer survival [15]. Finally, T was positively associated with epithelial ovarian cancer risk [17].…”

Section: Introductionmentioning

confidence: 99%

Parallel targeted and non-targeted quantitative analysis of steroids in human serum and peritoneal fluid by liquid chromatography high-resolution mass spectrometry

et al. 2022

View full text Add to dashboard Cite

We developed and validated a liquid chromatography high-resolution mass spectrometry method for the absolute quantification of 51 steroids for clinical analysis of human serum and, for the first time, peritoneal fluid. Data acquisition was performed in both targeted and untargeted mode simultaneously, thus allowing the accurate and precise quantification of the main components of the classical steroid pathways (17 steroids) as well as the analysis of 34 additional non-classical steroids. For targeted analysis, validation was performed according to FDA guidelines, resulting, among other parameters, in accuracy < 13% RSD and precision < 10% relative error, for both inter- and intra-day validation runs. By establishing steroid-specific response factors, the calibration curves of the targeted analytes can be extended to untargeted analytes. This approach opens novel possibilities for the post hoc analysis of clinical samples as the data can be examined for virtually any steroid even after data acquisition, enabling facile absolute quantification once a standard becomes available. We demonstrate the applicability of the approach to evaluate the differences in steroid content between peripheral serum and peritoneal fluid across the menstrual cycle phases, as well as the effect of the synthetic gestagen dienogest on the steroid metabolome. Graphical abstract

show abstract

Blood steroid levels predict survival in endometrial cancer and reflect tumor estrogen signaling

Cited by 11 publications

References 42 publications

Association Between Abdominal Adipose Tissue Distribution and Risk of Endometrial Cancer: A Case-Control Study

Association Between Abdominal Adipose Tissue Distribution and Risk of Endometrial Cancer: A Case-Control Study

Association of laboratorial parameters and prognostic factors in uterine corpus cancer

Parallel targeted and non-targeted quantitative analysis of steroids in human serum and peritoneal fluid by liquid chromatography high-resolution mass spectrometry

Contact Info

Product

Resources

About