Blood Selenium Levels and Glutathione-Peroxidase Activities in University and Chronic Intravenous Hyperalimentation Subjects

Lane, Helen W.; Dudrick, Stanley J.; Warren, Doris C.

doi:10.3181/00379727-167-41184

Cited by 58 publications

(8 citation statements)

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“…The selenium content of the parenteral solutions used in our patients has not been determined, but previous studies have suggested a maximum intake of selenium from parenteral solutions of <0.6 to 1 jig/day. 1,2,13 This stands in contrast to the estimated requirement in adults of 65 to 224 jig/ day. 14 Obviously, the selenium content of parenteral solutions cannot be expected to be a significant contributor to whole blood selenium levels.…”

Section: Discussioncontrasting

confidence: 59%

Prediction of Whole Blood Selenium Levels in Patients on Long‐Term Parenteral Nutrition

Lipkin

Schumann

Young

et al. 1986

J Parenter Enteral Nutr

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In an attempt to define clinical variables which might predict the whole blood selenium level prior to supplementation, whole blood selenium levels were determined in 21 home parenteral nutrition patients who were not receiving selenium supplementation. These levels were examined for possible correlations by single and multivariant analysis with the following clinical parameters: age at initiation of home parenteral nutrition, months of home parenteral nutrition received, hematocrit, albumin, estimated length of remaining small bowel, kilocalories per kilogram actual body weight infused per day, grams protein per kilogram actual body weight infused per day, and multiple of ideal body weight. Of all the combinations of variables examined, the best correlation obtained was between whole blood selenium levels and the total kilocalories per kilogram body weight per day delivered intravenously (r = -0.89, p less than 0.001). A statistically significant correlation (r = -0.67, p less than 0.01) was also observed between selenium levels and the grams protein per kilogram actual body weight infused per day. However, inclusion of this or additional variables did not increase the predictive value of the equation describing whole blood selenium levels as a function of the calories delivered. The implication of this study is that patients requiring more intensive nutritional support develop lower selenium levels during the course of treatment. Despite these correlations, no single clinical parameter or combination of parameters, however, was of sufficient predictive value to preclude laboratory determination of whole blood selenium values in deciding which patients might benefit from selenium supplementation.

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Section: Discussioncontrasting

confidence: 59%

Prediction of Whole Blood Selenium Levels in Patients on Long‐Term Parenteral Nutrition

Lipkin

Schumann

Young

et al. 1986

J Parenter Enteral Nutr

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“…It is part of the active site of glutahione peroxidase (GSH-Px) (Forstrom et al 1978). A good correlation is found between Se deficiency syndromes and low concentration of GSH-Px in animal tissues; in man, GSH-Px in blood is con¬ sidered as an indicator of the Se nutritional status (Lane et al 1981).…”

mentioning

confidence: 98%

Effects of a selenium deficient diet on thyroid function of normal and perchlorate treated rats

Golstein¹,

Corvilain²,

Lamy³

et al. 1988

Acta Endocrinologica

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Pregnant rats were submitted to a selenium\x=req-\ deficient diet immediately after mating; it was continued for 4 weeks after delivery. The pups were sacrificed at 3 and 4 weeks of age. Perchlorate, an antithyroid agent inhibiting iodide trapping in the thyroid, was administered via the drinking water to half of the rats. Rats submitted to a normal laboratory diet and to the experimental diet supplemented with selenium were used as controls. The effects of selenium deficiency were an increase in the number of growth abnormalities, growth retardation, and decreased seleno-dependent glutathione peroxidase (GSH-Px) activity in plasma and in various organs. These effects were relieved by selenium supplementation in the diet. Perchlorate treatment induced the classic picture of primary hypothyroidism. Selenium deficiency increased thyroid hormone levels in perchlorate-treated rats and in controls drinking tap water. In the latter group, it also decreased TSH plasma concentration and thyroid weight. These effects were partially reversed by Se supplementation. In vitro experiments, performed on adult rats, revealed increased radioiodide uptake and organification in glands from the rats submitted to the selenium-free diet. Plasma T3 half-life was similar in control and Se-deficient rats. These data suggest a higher efficiency of thyroid hormone synthesis in the thyroids of selenium-deficient rats, despite a lower thyroid stimulation as evaluated by serum TSH. They are compatible with the hypothesis that decreased selenium supply, leading to a decreased GSH-Px in the thyroid, increases hydrogen peroxide steady state level and thus thyroid peroxidase activity and thyroid hormone synthesis.

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“…On the one hand, some studies 28–30 have failed to show a correlation between Se concentration and GPX activity, whereas others have suggested that a positive correlation does exist. 31–33…”

Section: Discussionmentioning

confidence: 99%

Selenium status in patients with aspirin-induced asthma

Hassan

2008

Ann Clin Biochem

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Background: Platelets are involved in the pathogenesis of aspirin-induced asthma (AIA). AIA patients suffer from an active disease despite avoidance of aspirin, and it has been suggested that administration of aspirin to these patients increases the generation of immediate oxygen products of arachidonic acid, 12-hydroperoxyeicosatetraenoic acid (12-HPETE), in their platelets. 12-HPETE further activates the 5-lipoxygenase of leukotriene B4-producing inflammatory macrophages precipitating an acute asthmatic attack. Glutathione peroxidase (GPX) has the antioxidant capacity to reduce 12-HPETE, and thus modulate the arachidonic acid metabolic cascade. There is evidence that selenium (Se) nutrition can influence asthma but Se status in AIA patients has not received much attention. Methods: We measured Se concentrations and GPX activities in platelets and plasma from 13 patients with AIA. Age-and sex-matched healthy individuals served as the control group. Results: Patients with AIA had significantly higher median platelet Se concentration (102 ng/mg platelet protein) when compared with controls (49 ng/mg platelet protein, P ¼ 0.003). Plasma Se concentrations in patients with AIA and controls were not significantly different (P ¼ 0.59). Median platelet GPX activity was significantly higher in patients with AIA (102.7 mU/mg platelet protein) than in controls (66 mU/mg protein) (P ¼ 0.05). The patient and control groups when combined showed weak, but significant correlation between platelet Se concentration and platelet GPX activity (r ¼ 0.44; P ¼ 0.03). Conclusion: It is proposed that the higher platelet Se concentration observed in AIA patients contributed to the higher platelet GPX activity seen in these patients. Such an enhanced antioxidant defence system might represent an adaptive response to protect against increasing free radical production by inflammatory cells in AIA and help decelerate ongoing respiratory hypersensitivity.

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Blood Selenium Levels and Glutathione-Peroxidase Activities in University and Chronic Intravenous Hyperalimentation Subjects

Cited by 58 publications

References 0 publications

Prediction of Whole Blood Selenium Levels in Patients on Long‐Term Parenteral Nutrition

Prediction of Whole Blood Selenium Levels in Patients on Long‐Term Parenteral Nutrition

Effects of a selenium deficient diet on thyroid function of normal and perchlorate treated rats

Selenium status in patients with aspirin-induced asthma

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