Blood retinol and retinol-binding protein concentrations are associated with diabetes: a systematic review and meta-analysis of observational studies

Lu, Jianying; Wang, Dandan; Ma, Baolan; Gai, Xiaochun; Xiao, Kang; Wang, Jinyu; Xiong, Ke

doi:10.1007/s00394-022-02859-2

Cited by 4 publications

(1 citation statement)

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“…Research in this area has mainly focused on RBP4, and most studies have found that RBP4 concentrations were significantly positively associated with a higher risk of GDM. 8 However, retinol, the main circulating form of vitamin A, has been far less studied. A retrospective study found that vitamin A levels in early pregnancy had a nonsignificantly positive association with GDM.…”

Section: Introductionmentioning

confidence: 99%

Associations Between Serum Vitamin A Levels in Early Pregnancy and the Risk of Gestational Diabetes Mellitus

Yu,

Liu,

2024

DMSO

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Background The relationship between vitamin A levels and gestational diabetes mellitus (GDM) is not well understood, and prospective studies are lacking. Methods This was a prospective, longitudinal study. A total of 391 women in early pregnancy were recruited between October and December 2018 at Shunyi District Maternal and Child Health Hospital (Beijing, China). Serum vitamin A concentration was measured at enrollment. GDM was diagnosed on the basis of a 75 g oral glucose-tolerance test at 24–28 weeks of follow-up. Logistic regression was used for the analysis. Results None of the subjects in the cohort had vitamin A deficiency or excess. At the follow-up, 76 participants had developed GDM. Participants who developed GDM were older and had higher body mass index, fasting insulin, HbA 1c , fasting glucose, homeostasis model assessment for insulin resistance, triglyceride, low-density lipoprotein cholesterol , and high-sensitivity CRP levels, as well as higher serum vitamin A levels at baseline. On logistic multivariate analysis, higher vitamin A was positively associated with higher risk of GDM. The adjusted OR was 2.85 (95% CI 1.04–7.80, P =0.042) for Q4 versus Q1 and 1.59 (95% CI 1.11–2.28, P =0.011) for every 1 SD increase in serum vitamin A levels. In participants within the vitamin A reference range (0.33–0.78 mg/L), the positive association also maintained significance. Conclusion Higher serum vitamin A levels were associated with higher GDM risks, even within the reference range. The results and possible mechanisms need to be further verified and clarified.

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Section: Introductionmentioning

confidence: 99%