Blood‐Repellent Surfaces: Superhydrophobic Blood‐Repellent Surfaces (Adv. Mater. 24/2018)

Jokinen, Ville; Kankuri, Esko; Hoshian, Sasha; Franssila, Sami; Ras, Robin H. A.

doi:10.1002/adma.201870173

Cited by 24 publications

(28 citation statements)

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“…To solve these, researchers have dedicated to developing biomaterials with specific wettability, together with adding antibacterial ingredients for further treatment. Up to date, medical dressings based on biomaterials with specific wettability have demonstrated values in accelerating the wound healing process through removing excessive biofluid around wounds, [ 96,174 ] inhibiting adhesion of harmful biomolecules, [ 175–179,174,180–234 ] and releasing therapeutic drugs or molecules. [ 175–179,174,180,235–237 ]…”

Section: Biomaterials and Tissue Engineeringmentioning

confidence: 99%

“…Among them, superwetting coatings are receiving extensive attention for their excellent antibiofouling performances by simply adjusting surface energy and topography. [ 208 ] For example, Ren et al. developed a kind of CuO nanoparticle‐contained superhydrophobic coating with excellent bacteria anti‐adhesion capacity and bactericidal performance.…”

Section: Medical Apparatus and Instrumentsmentioning

confidence: 99%

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Tailoring Materials with Specific Wettability in Biomedical Engineering

et al. 2021

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As a fundamental feature of solid surfaces, wettability is playing an increasingly important role in our daily life. Benefitting from the inspiration of biological paradigms and the development in manufacturing technology, numerous wettability materials with elaborately designed surface topology and chemical compositions have been fabricated. Based on these advances, wettability materials have found broad technological implications in various fields ranging from academy, industry, agriculture to biomedical engineering. Among them, the practical applications of wettability materials in biomedical-related fields are receiving remarkable researches during the past decades because of the increasing attention to healthcare. In this review, the research progress of materials with specific wettability is discussed. After briefly introducing the underlying mechanisms, the fabrication strategies of artificial materials with specific wettability are described. The emphasis is put on the application progress of wettability biomaterials in biomedical engineering. The prospects for the future trend of wettability materials are also presented.

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Section: Biomaterials and Tissue Engineeringmentioning

confidence: 99%

Section: Medical Apparatus and Instrumentsmentioning

confidence: 99%

Tailoring Materials with Specific Wettability in Biomedical Engineering

et al. 2021

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“…Skin injuries produce bleeding and excessive biofluid which may cause bacterial infection, chronic non‐healing wounds, and serious tissue damage. In recent years, great advances have been emerged to control skin bleeding such as self‐sealing needles, [ 1 ] blood repellent dressings, [ 2 ] as well as Janus fabrics. [ 3 ] However, there is still a major challenge in managing excessive biofluid which would delay wound healing.…”

Section: Introductionmentioning

confidence: 99%

Elastic Janus film for Wound Dressings: Unidirectional Biofluid Transport and Effectively Promoting Wound Healing

Wang

et al. 2021

Adv Funct Materials

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The intrinsic hydrophilicity of conventional dressings cannot achieve effective management of excessive biofluid around the wound bed, which inevitably causes infection and hinders wound healing. In addition, present dressings such as medical gauze or band aids have a limited stretching capability, which does not comply well with the skin deformation during muscle movement, thus impacting patient comfort. Herein, a Janus wound dressing is reported by assembling an external hydrophobic (HP) adhesive tape, a filter paper, and a polydimethylsiloxane (PDMS) Janus film. The PDMS Janus film as the primary dressing can unidirectionally remove biofluid away from the wound bed. The mechanism of the unidirectional biofluid transport is investigated, demonstrating that the stretching or bending of the Janus dressing is beneficial for unidirectional biofluid draining. It indicates that the Janus PDMS film has potential for practical applications on stretched or bended skin surface. In addition, in order to prevent bacterial infection, amoxicillin powder is uniformly encapsulated on the HP layer of Janus film, resulting in faster wound healing. This study is valuable for designing and fabricating next-generation dressings with high performance for clinical applications.

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“…To repel blood, we need omniphobicity, which has both hydrophobicity and oleophobicity, because blood is a complex mixture of water, lipids, proteins, and blood cells. Therefore, to repel blood, at first, some structures in nature including lotus leaves and bird feathers were mimicked for increasing the hydrophobicity, but they showed lower oleophobicity than the flat surface; therefore, they cannot have oleophobicity without additional chemical coatings. − As Nepenthes’s lubricant repels oily fluids, chemical coatings such as perfluoro compounds are widely used. − However, these chemicals are generally toxic and degrade over time. Therefore, it is not advisable to use chemical coatings directly for biomedical purposes and long-term processes.…”

Section: Introductionmentioning

confidence: 99%

Flexible and Stable Omniphobic Surfaces Based on Biomimetic Repulsive Air-Spring Structures

Seo

Kyong

Kim

et al. 2019

ACS Appl. Mater. Interfaces

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In artificial biological circulation systems such as extracorporeal membrane oxygenation, surface wettability is a critical factor in blood clotting problems. Therefore, to prevent blood from clotting, omniphobic surfaces are required to repel both hydrophilic and oleophilic liquids and reduce surface friction. However, most omniphobic surfaces have been fabricated by combining chemical reagent coating and physical structures and/or using rigid materials such as silicon and metal. It is almost impossible for chemicals to be used in the omniphobic surface for biomedical devices due to durability and toxicity. Moreover, a flexible and stable omniphobic surface is difficult to be fabricated by using conventional rigid materials. This study demonstrates a flexible and stable omniphobic surface by mimicking the re-entrant structure of springtail’s skin. Our surface consists of a thin nanohole membrane on supporting microstructures. This structure traps air under the membrane, which can repel the liquid on the surface like a spring and increase the contact angle regardless of liquid type. By theoretical wetting model and simulation, we confirm that the omniphobic property is derived from air trapped in the structure. Also, our surface well maintains the omniphobicity under a highly pressurized condition. As a proof of our concept and one of the real-life applications, blood experiments are performed with our flat and curved surfaces and the results including contact angle, advancing/receding angles, and residuals show significant omniphobicity. We hope that our omniphobic surface has a significant impact on blood-contacting biomedical applications.

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Blood‐Repellent Surfaces: Superhydrophobic Blood‐Repellent Surfaces (Adv. Mater. 24/2018)

Cited by 24 publications

References 0 publications

Tailoring Materials with Specific Wettability in Biomedical Engineering

Tailoring Materials with Specific Wettability in Biomedical Engineering

Elastic Janus film for Wound Dressings: Unidirectional Biofluid Transport and Effectively Promoting Wound Healing

Flexible and Stable Omniphobic Surfaces Based on Biomimetic Repulsive Air-Spring Structures

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