Blood protein coating of gold nanoparticles as potential tool for organ targeting

Schäffler, Martin; Sousa, Fernanda S. de; Wenk, Alexander; Sitia, Leopoldo; Hirn, Stephanie; Schleh, Carsten; Haberl, Nadine; Violatto, Martina Bruna; Canovi, Mara; Andreozzi, Patrizia; Salmona, Mario; Bigini, Paolo; Kreyling, Wolfgang G.; Krol, Silke

doi:10.1016/j.biomaterials.2013.12.100

Cited by 115 publications

(85 citation statements)

References 51 publications

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“…These results could be applied to tailor nanomaterials that target the brain and the lung. 90 Though in some reported cases, the targeting properties of NPs may be hindered by protein adsorption, preventing the interaction of functional ligands with corresponding cell receptors. 91 For example, transferrin-modified NPs lose their targeting effect due to surface adsorption of biomolecules.…”

Section: Targeting Purposementioning

confidence: 99%

Protein corona: a new approach for nanomedicine design

Nguyen¹,

Lee²

2017

IJN

521

343

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After administration of nanoparticle (NP) into biological fluids, an NP–protein complex is formed, which represents the “true identity” of NP in our body. Hence, protein–NP interaction should be carefully investigated to predict and control the fate of NPs or drug-loaded NPs, including systemic circulation, biodistribution, and bioavailability. In this review, we mainly focus on the formation of protein corona and its potential applications in pharmaceutical sciences such as prediction modeling based on NP-adsorbed proteins, usage of active proteins for modifying NP to achieve toxicity reduction, circulation time enhancement, and targeting effect. Validated correlative models for NP biological responses mainly based on protein corona fingerprints of NPs are more highly accurate than the models solely set up from NP properties. Based on these models, effectiveness as well as the toxicity of NPs can be predicted without in vivo tests, while novel cell receptors could be identified from prominent proteins which play important key roles in the models. The ungoverned protein adsorption onto NPs may have generally negative effects such as rapid clearance from the bloodstream, hindrance of targeting capacity, and induction of toxicity. In contrast, controlling protein adsorption by modifying NPs with diverse functional proteins or tailoring appropriate NPs which favor selective endogenous peptides and proteins will bring promising therapeutic benefits in drug delivery and targeted cancer treatment.

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Section: Targeting Purposementioning

confidence: 99%

Protein corona: a new approach for nanomedicine design

Nguyen¹,

Lee²

2017

IJN

521

343

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“…An example of this has been recently published by Schäffler et al, who demonstrated that the coating of AuNPs with albumin massively reduced their retention in the liver [101].…”

Section: Toxicity and Biodistributionmentioning

confidence: 94%

Gold Nanoparticles for Photothermally Controlled Drug Release

Guerrero

Hassan

Escobar

et al. 2014

Nanomedicine (Lond.)

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In this article, we describe how nanoparticles work in photothermally triggered drug delivery, starting with a description of the plasmon resonance and the photothermal effect, and how this is used to release a drug. Then, we describe the four major functionalization strategies and each of their different applications. Finally, we discuss the biodistribution and toxicity of these systems and the necessary requirements for the use of gold nanoparticles for spatially and temporally controlling drug release through the photothermal effect.

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“…The surface properties (degree of hydrophobicity and charge) will further influence protein adsorption and drug desorption during circulation, a factor that has been shown to also dramatically influence the pharmacokinetic and biodistribution of the active molecule, by either promoting reticulo-endothelial system (RES) clearance or enhancing targeting. Recently, mathematical models have been developed in order to predict cellular interactions according to surface physico-chemistry properties and the resulting protein corona fingerprint 32 , opening the way of rational tuning of the nature of the nanocarrier backbone to induce a preferential adsorption of certain proteins and promote organ targeting 33,34 .…”

Section: A N U S C R I P Tmentioning

confidence: 99%