Blood profiles in dairy cows with displaced abomasum

Abstract

An observational study was carried out in Swedish dairy herds to investigate differences between cows with and without displaced abomasum (DA), in concentrations of glucose, insulin, fructosamine, nonesterified fatty acids (NEFA), β-hydroxybutyrate, cholesterol, haptoglobin, increased enzyme activity of aspartate aminotransferase and glutamate dehydrogenase, and the revised Quantitative Insulin Sensitivity Check Index (RQUICKI). A secondary aim was to study how blood profiles for DA cows vary with time in relation to calving. Sixty-nine DA cows within 2 to 56 d postpartum, in 60 herds, were clinically examined and blood samples were drawn at the time DA was diagnosed. At the same time, 104 healthy control cows matched by herd and stage of lactation were also sampled. The blood parameters were studied using mixed linear models, including herd as a random effect, and DA (case or control), parity, breed, sampling time in relation to calving, other diseases, and the interaction between DA and time as fixed effects. Concentrations were higher in DA cows than in control cows for NEFA (least squares means 1.36 vs. 0.34 mmol/L), β-hydroxybutyrate (1.56 vs. 0.90 mmol/L), aspartate aminotransferase (1.96 vs. 0.97 μkat/L), glutamate dehydrogenase (197 vs. 78 μkat/L), and haptoglobin (0.76 vs. 0.17 g/L), whereas concentrations were lower in DA cows than in control cows for insulin (3.61 vs. 8.48 mU/L) and cholesterol (3.04 vs. 3.75 mmol/L). Glucose (2.83 vs. 2.79 mmol/L) and fructosamine (266 vs. 252 μmol/L) concentrations were similar in both groups; however, a tendency toward lower RQUICKI values (0.42 vs. 0.46) in the DA cows was found, indicating reduced insulin sensitivity. For most blood parameters, differences between DA cows and controls remained constant over time. Seventy-two percent of the DA cows had at least one other disease in the period from 1 wk antepartum to 1 wk after the DA was diagnosed. Haptoglobin could potentially be used to detect treatable infectious or inflammatory conditions in the early postpartum period, possibly reducing the incidence of DA. Consequently, there were major changes in blood profiles in cows with DA compared with healthy control cows, indicating a negative energy balance, liver cell damage, and an inflammatory response. The results contribute to an understanding of the metabolic changes in DA cows.

Changes of hematological and biochemical parameters and levels of pepsinogen, histamine and prostaglandins in dairy cows affected with left displacement of the abomasum

“…This dehydration could be the result of a lack of intake and failure to absorb fluids from the proximal gastrointestinal tract due to partial or complete obstruction. In the leukogram, some researchers found increased numbers of leukocytes and neutrophelia (Stengärde et al 2010). They attributed these changes to immunological responses against endotoxemia and abomasitis that may occur secondarily to LDA (Stengärde et al 2010).…”

“…In the leukogram, some researchers found increased numbers of leukocytes and neutrophelia (Stengärde et al 2010). They attributed these changes to immunological responses against endotoxemia and abomasitis that may occur secondarily to LDA (Stengärde et al 2010). In the study reported here, only otherwise healthy cows were included in the study.…”

NMR-based metabolomic evaluation in dairy cows with displaced abomasum

“…In the present study there was only mild hypokalemia without metabolic alkalosis. Biochemical profiles reflecting energy balance, hepatic function, and inflammatory response are used for the evaluation of peripartum diseases in cows (14). In cows that develop displacement of the abomasum, ketosis may be an important risk factor (3).…”

An Attempt to Prevent Production Diseases in Dairy andad hocTreatment Cows by Intense Monitoring

“…This accumulation of fatty acids in the liver predisposes the cow to the induction of ketosis accompanied by an elevation of serum betahydroxybutyrate (b-HOB). Various authors have already demonstrated that the blood levels of b-HOB, NEFA and calcium (Ca) are closely correlated with the incidence of production diseases ( Hoedemaker et al, 2004;Goff, 2006;Stengärde et al, 2010;Chapinal et al, 2012Chapinal et al, , 2011.…”