Blood product irradiation recommendations

McGill, Manley; Balakrishnan, Kamala; Meier, Terry; Mayhaus, Charles; Whitacre, Lynn

doi:10.1046/j.1537-2995.1986.26687043623.x

Cited by 11 publications

(4 citation statements)

References 3 publications

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“…With the use of the mixed lymphocyte culture (MLC) assay, the proliferation of lymphocytes in response to allogeneic cells was reported to be completely abolished after exposure to 500 cGy 26–28 . A dose of 1000 to 3000 cGy was needed to reduce the MLC response to background levels when radiation was delivered to cells contained in bulky, irregularly shaped blood bags 29–31 32 …”

Section: Discussionmentioning

confidence: 99%

In vitro and in vivo measurementsof gamma‐radiated, frozen, glycerolized RBCs

et al. 2001

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Section: Discussionmentioning

confidence: 99%

In vitro and in vivo measurementsof gamma‐radiated, frozen, glycerolized RBCs

et al. 2001

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“…Based on some clinical results, an increase in gamma Irradiation dose might be a choice in achieving more effective Inhibition of lymphocyte proliferation [5,6]. Effects of gamma Irradiation on platelets are considered äs having only minimal effects on platelet properties whether or not the units were stored following treatment [18].…”

Section: Discussionmentioning

confidence: 99%

“…Some clinical results however indicated that doses of 15-20 Gy might be inadequate [1][2][3] and it has been suggested that existing blood product Irradiation guidelines may require reassessment [1]. Some authors agree that transftision-associated GVHD in both children and adults is probably under-reported [4] and therefore an increase of Irradiation dose might be considered äs a way of achieving more effective Inhibition of lymphocyte proliferation according to some studies [5,6].…”

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Platelet Damage Following Irradiation and Five Days' Storage – Thrombozytenschädigung nach Bestrahlung und fünftägiger Lagerung

Rácz¹

1998

LaboratoriumsMedizin

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Platelet concentrates prepared from fresh blood were treated with gamma Irradiation of 15 to 525 Gy and stored under Standard biood bank conditions. Following 5 days' storage platelets were studied for mean platelet volume (MPV), ATP content, hypotonic shock reaction (HSR) and aggregation. Experimental results were expressed either in absolute terms or äs indices of irradiated/non-irradiated data. Gamma Irradiation showed a dose-dependent effect on the studied parameters of stored platelets. Platelet MPV increased while ATP content and HSR decreased with increasing dose of Irradiation. Linear correlation between Irradiation dose and these parameters was stronger when index values (irradiated/non-irradiated) were correlated to Irradiation doses instead of the measured parameters in absolute terms. The effect on platelet aggregation was more complex, because doses less than 25 and higher than 200 Gy exerted potentiating effect, while those between 25 and 200 Gy inhibited aggregability. It was concluded that in order to increase radiä-tion-induced lymphocyte damage in PCs, gamma irradiation doses higher than those currently used may be applied without sudden increase in platelet injury. • Zusammenfassung: Aus Frischblut hergestellte Thrombozyten-Konzentrate wurden mit Gammastrahlen in Dosen zwischen 15 und 525 Gy behandelt und unter Standard-Blutbankbedingungen gelagert. Nach fünftägiger Lagerung wurden die Thrombozyten hinsichtlich mittlerem Plättchenvolumen (MPV), ATPGehalt, hypotoner Schockreaktion (HSR) und Aggregationsverhalten untersucht. Die Versuchsergebnisse wurden entweder in absoluten Größen oder als Index, gebildet aus den Daten bestrahlter/nicht bestrahlter Präparate, ausgedrückt. Die Behandlung mit Gammastrahlen zeigte einen dosisabhängigen Effekt. Das

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“…Irradiation of blood to prevent PT‐GVHD should be performed at a dose between 15 and 50 Gy ( Thomas et al ., 1975 ; McGill et al ., 1986 ; Moroff & Luban, 1992) .…”

Section: Text Of the Guidelinesmentioning

confidence: 99%

Guidelines for irradiation of blood and blood components to prevent post‐transfusion graft‐vs.‐host disease in Japan

Asai

Inaba

Ohto

et al. 2000

Transfusion Medicine

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The Japanese Red Cross analysed the results of questionnaires sent in 1993 regarding post-transfusion graft-vs.-host disease (PT-GVHD) from hospitals; the majority of patients with PT-GVHD in 1993 were transfused for cardiovascular or cancer surgery, and about 10 patients had died yearly from PT-GVHD in the following few years. The Japan Society of Blood Transfusion (JSBT) organized a subcommittee for the prevention of PT-GVHD, and issued a fourth version of guidelines for the irradiation of blood to prevent PT-GVHD. These guidelines recommended transfusion of irradiated blood for cardiosurgery, cancer surgery, elderly recipients and severe trauma, as well as congenital immunodeficient recipients, newborn infants and other immunocompromised patients. Also recommended was irradiation not only of blood within 72 h after collection but also of blood stored for 14 days. Reported PT-GVHD has diminished to a few cases in recent years.

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Blood product irradiation recommendations

Cited by 11 publications

References 3 publications

In vitro and in vivo measurementsof gamma‐radiated, frozen, glycerolized RBCs

In vitro and in vivo measurementsof gamma‐radiated, frozen, glycerolized RBCs

Platelet Damage Following Irradiation and Five Days' Storage – Thrombozytenschädigung nach Bestrahlung und fünftägiger Lagerung

Guidelines for irradiation of blood and blood components to prevent post‐transfusion graft‐vs.‐host disease in Japan

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