Blood Pressure Trajectory and Its Influencing Factors in Chinese Adults: A Cohort Study with Long-Term Follow-Up

Yao, Chaoyong; Wei, Zengxin

doi:10.12659/msm.934886

Cited by 3 publications

(1 citation statement)

References 26 publications

(26 reference statements)

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“…In a recent study of Chinese adults that explored the factors that influence BP trajectories, the participants were divided into three groups based on the SBP trajectory. Among them, an age of ≥40 years, male sex, a BMI of ≥24 kg/m 2 , and Eastern region location were potential factors that influenced the rapid increase in the SBP trajectory and high baseline SBP [ 15 ]. In addition, other studies have reported that lifestyle [ 16 ], fasting blood glucose level [ 17 ], and blood lipid levels [ 18 ] are also closely related to the BP level.…”

Section: Introductionmentioning

confidence: 99%

Association between the Systolic Blood Pressure Trajectory and Risk of Stroke in a Health-Management Population in Jiaozuo, China

Zhang

Xiang-dong

et al. 2022

Journal of Healthcare Engineering

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The trajectories of systolic blood pressure (SBP) in a screening population in Jiaozuo were examined, and the association between the different types of SBP trajectories and the risk of stroke was evaluated. Data of a fixed cohort population from the Jiaozuo Stroke Prevention and Control Project Management Special Database System that underwent community screening in 2015, 2017, 2019, and 2021 were collected. Ultimately, a total of 1,451 participants who met the inclusion criteria for this study were included in the analysis, which was performed using group trajectory modeling. The baseline SBP for each trajectory subgroup was characterized at follow-up. Kaplan–Meier analysis for each trajectory group was also performed, and the relationship between the SBP trajectory and risk of stroke onset during follow-up was validated using a Cox proportional hazards model. Based on the SBP from 2015 to 2021, this cohort population was divided into three groups based on the trajectory development patterns: the low-stable group (37.6%), the moderate-increasing group (53.4%), and the high-acutely increasing group (9%). Gender, age, body mass index, diastolic blood pressure, and fasting blood glucose level were predictive factors for the SBP trajectory group. The cumulative survival risk in the high-acutely increasing group was higher than that of the other two groups. After adjusting for potential confounding factors and using the low-stable group as a reference, the hazard ratios (95% confidence interval) for the risk of stroke onset in the moderate-increasing and high-acutely increasing groups were 1.38 (0.91–2.07) and 1.51 (0.82–2.76), respectively. The results of the analysis demonstrate that higher blood pressure trajectories are associated with a higher risk of stroke and that the risk of stroke can be reduced by better control and management of the SBP.

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Section: Introductionmentioning

confidence: 99%

Association between the Systolic Blood Pressure Trajectory and Risk of Stroke in a Health-Management Population in Jiaozuo, China

Zhang

Xiang-dong

et al. 2022

Journal of Healthcare Engineering

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Relationship between trajectories of dietary iron intake and risk of type 2 diabetes mellitus: evidence from a prospective cohort study

Wang,

Liu,

Thabane

et al. 2024

Nutr J

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Background The association between dietary iron intake and the risk of type 2 diabetes mellitus (T2DM) remains inconsistent. In this study, we aimed to investigate the relationship between trajectories of dietary iron intake and risk of T2DM. Methods This study comprised a total of 61,115 participants without a prior T2DM from the UK Biobank database. We used the group-based trajectory model (GBTM) to identify different dietary iron intake trajectories. Cox proportional hazards models were used to evaluate the relationship between trajectories of dietary iron intake and risk of T2DM. Results During a mean follow-up of 4.8 years, a total of 677 T2DM events were observed. Four trajectory groups of dietary iron intake were characterized by the GBTM: trajectory group 1 (with a mean dietary iron intake of 10.9 mg/day), 2 (12.3 mg/day), 3 (14.1 mg/day) and 4 (17.6 mg/day). Trajectory group 3 was significantly associated with a 38% decreased risk of T2DM when compared with trajectory group 1 (hazard ratio [HR] = 0.62, 95% confidence interval [CI]: 0.49–0.79), while group 4 was significantly related with a 30% risk reduction (HR = 0.70, 95% CI: 0.54–0.91). Significant effect modifications by obesity (p = 0.04) and history of cardiovascular disease (p < 0.01) were found to the relationship between trajectories of dietary iron intake and the risk of T2DM. Conclusions We found that trajectories of dietary iron intake were significantly associated with the risk of T2DM, where the lowest T2DM risk was observed in trajectory group 3 with a mean iron intake of 14.1 mg/day. These findings may highlight the importance of adequate dietary iron intake to the T2DM prevention from a public health perspective. Further studies to assess the relationship between dietary iron intake and risk of T2DM are needed, as well as intervention studies to mitigate the risks of T2DM associated with dietary iron changes.

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The importance of CYP1A2 genetic polymorphism in relation to coffee intake and high blood pressure in the Romanian population

Popa,

Farcas,

Andreescu

2024

Preprint

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Cytochrome P450 1A2 (CYP1A2) is known to be the main enzyme directly responsible for caffeine metabolism. The rs762551 (NC_000015.10:g.74749576C > A) is a single nucleotide polymorphism characterized by higher enzyme activity in the presence of an inducer such as heavy coffee consumption and its protective role against developing cardiovascular diseases, including high blood pressure. In this comprehensive study, we aim to evaluate any association between coffee intake, CYP1A2 polymorphism, the presence of high blood pressure, and their potential role in cardiovascular outcomes. For 355 individuals, a PCR technique was performed using TaqMan SNP genotyping Assay, analyzing rs762551 on LightCycler 480 (Roche) with Gene Scanning software version 1.5.1 (Roche). Using binomial logistic regression, we found that the individuals who consumed more than three cups of coffee per day are less likely to fit in the slow coffee metabolizers category with an odds ratio of 0.386 and p = 0.033. Another important finding would be the fact that the fast coffee metabolizers (AA genotype) consume larger coffee quantities, although they present the lowest tensional values and the highest values for cholesterol and glucose. When approaching the hypertensive subjects, they show lower coffee consumption and lower caffeine levels, compared to the control group. The main conclusion of this study would be that only coffee intake and genotype are statistically related, although no statistically significant associations regarding the high blood pressure have been found.

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Blood Pressure Trajectory and Its Influencing Factors in Chinese Adults: A Cohort Study with Long-Term Follow-Up

Cited by 3 publications

References 26 publications

Association between the Systolic Blood Pressure Trajectory and Risk of Stroke in a Health-Management Population in Jiaozuo, China

Association between the Systolic Blood Pressure Trajectory and Risk of Stroke in a Health-Management Population in Jiaozuo, China

Relationship between trajectories of dietary iron intake and risk of type 2 diabetes mellitus: evidence from a prospective cohort study

The importance of CYP1A2 genetic polymorphism in relation to coffee intake and high blood pressure in the Romanian population

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