Editorialblurring of vision or headache. All patients successfully underwent percutaneous interventions. The results disclosed a substantial reduction in BP with systolic BP decreasing from 185 ± 18 mmHg to 153 ± 25 mmHg (p<0.001). Similarly, diastolic BP decreased from 96 ± 14 to 87 ± 14 mmHg (p<0.001). Interestingly, antihypertensive medications were not used before, during or following the percutaneous interventions, yet nearly 30 mmHg decline in systolic and roughly 10 mmHg decrease in diastolic BP was observed in these patients. Importantly, the study demonstrated that none of the patients had an acute pulmonary edema, myocardial infarction or stroke before, during, or following the percutaneous procedures. Additionally, no patients had any of these complications during the 4-week follow-up period.The above-cited study provides evidence that dialysis patients undergoing percutaneous interventions can successfully undergo procedures despite BP in a range that could potentially make an interventionalist nervous about undertaking an intervention (1). The procedures then allow for access to be available for dialysis therapy. A question which comes to mind is why did the BP go down without the administration of an antihypertensive agent? The investigators offered some explanation. The contribution of anxiety and sympathetic discharge is frequently downplayed and often ignored. Sympathetic stimulation is a powerful stimulus to raise BP. Despite dialysis patients frequently undergo dialysis access procedures, they are often anxious when they arrive to the procedure room. This can drive BP up. Sedatives, such as midazolam, can be used during a procedure to reduce anxiety. Both midazolam and fentanyl administered during the procedures can also lower BP (2).Most non-ESRD procedures performed under conscious sedation can often be postponed for elevated BP to prevent/minimize procedure-related complications. Indeed, well-controlled Hypertension is a major cause of stroke, congestive heart failure, coronary artery disease and end-stage renal disease (ESRD). Because of volume overload, hypertension is particularly prevalent in the dialysis population. Interventionalists debate whether to postpone a case with high blood pressure (BP) until the pressure is within an acceptable range; however, this is one situation where dialysis access is absolutely required to provide life-sustaining therapy and to remove excess volume to make an impact on reducing pressure.In general, it is stage II hypertension (BP ≥160/100 mmHg) that often draws particular attention prior to the procedure. At least one study has investigated patients undergoing percutaneous dialysis access interventions with a systolic BP ≥160 mmHg (1). In that study, 103 dialysis patients undergoing percutaneous interventions (tunneled hemodialysis catheter insertion and percutaneous balloon angioplasty, stent placement, and thrombectomy procedures) were included. All patients included in the study demonstrated an asymptomatic pre-procedure systolic BP of ≥160 mmHg (m...