Blood pressure load determines left ventricular mass in essential hypertension

Bauwens, Frank; Duprez, Daniel; Buyzere, Marc De; Clément, Denis

doi:10.1016/0167-5273(92)90032-x

Cited by 36 publications

(25 citation statements)

References 12 publications

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“…Most ABPM analyses consist of mean BP measurements; however, percent BP load greater than 30% has also been used to define hypertension [6]. Also, in adults higher BP load has been shown to be associated with adverse cardiovascular risk profile independently of [9,10]. Our study does not examine the relationship between BP load and end organ damage in the pediatric patients studied.…”

Section: Discussionmentioning

confidence: 70%

Ambulatory blood pressure monitoring: mean blood pressure and blood pressure load

et al. 2005

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Ambulatory blood pressure monitoring (ABPM) is commonly used to diagnose pediatric hypertension. Using ABPM, hypertension is usually defined as a mean BP greater than the 95th percentile for height. A BP load >30% (% of BP readings greater than the 95th percentile) is also used for the diagnosis of hypertension. The objective of this study was to determine the agreement between mean BP greater than the 95th percentile and 30% BP load for the diagnosis of hypertension using ABPM. All ABPM records (n =1,009) of patients referred for hypertension to a pediatric center were retrieved. Scans were excluded if: age was >19 and height <115 cm or >185 cm. Mean BP and BP loads were calculated for 728 scans. Agreement between mean BP greater than the 95th percentile for height and various BP loads were calculated using the kappa coefficient. The kappa coefficient of agreement between mean BP greater than the 95th percentile and 30% BP load was 0.56 and 0.57 for daytime systolic and diastolic BP, respectively. The agreement between mean night-time BP greater than the 95th percentile and 30% BP load was 0.70 and 0.66 for systolic and diastolic BP, respectively. Agreement between mean BP greater than the 95th percentile and 30% BP load is only moderate to good. Maximum agreement between mean BP greater than the 95th percentile and BP load is achieved at 50% BP load.

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Section: Discussionmentioning

confidence: 70%

Ambulatory blood pressure monitoring: mean blood pressure and blood pressure load

et al. 2005

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“…Several studies have shown an association between LVM and BP levels, but these mainly involved hypertensive subjects (6,7,(18)(19)(20)(21)(22)(23)(24). There is little information about the association between LVM and BP in normotensive subjects.…”

Section: Discussionmentioning

confidence: 99%

“…The association between hypertension and left ventricular mass (LVM) has been clearly demonstrated in several studies (1,(6)(7)(8)(9). Lauer et al demonstrated that systolic BP, and to a lesser degree diastolic BP, are independent markers associated with increased LVM (9).…”

Section: Introductionmentioning

confidence: 99%

Interventricular Septum Thickness Predicts Future Systolic Hypertension in Young Healthy Pilots

Grossman

Grossman²,

Koren‐Morag

et al. 2008

Hypertens Res

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“…It has been consistently shown that ambulatory BP measurements are more powerful to predict LVH than is office BP. 26,27 However, multiple subgroup analyses with and without adjustment for BP levels failed to show in the present study an association between the GNB3 poly- …”

Section: Discussionmentioning

confidence: 38%

Relation of the G Protein β ₃ -Subunit Polymorphism With Left Ventricle Structure and Function

et al. 2002

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Abstract-The G protein ␤ 3 -subunit C825T polymorphism results in a truncated splice variant protein that is associated with enhanced transmembrane signaling, increased proliferative activity, and arterial hypertension. The aim of the present study was to further investigate the association of this polymorphism with left ventricular (LV) structure and function. A total of 2052 individuals from a large-scale population-based sample were investigated for the G protein ␤ 3 -subunit C825T polymorphism and echocardiographic parameters of LV structure and function. Complete genotyping and echocardiographic data were available in 1720 individuals (829 men and 891 women). The mean LV mass indices in men with CC (nϭ384) and TT (nϭ84) genotypes were 98.3Ϯ1.2 g/m 2 and 100.0Ϯ2.8 g/m 2 , respectively (Pϭ0.64). In women, the corresponding values were 83.1Ϯ1.0 g/m 2 for the CC genotype (nϭ397) and 83.8Ϯ2.1 g/m 2 for the TT genotype (nϭ91, Pϭ0.32). Likewise, LV dimensions or parameters of the diastolic function and serologic markers of LV mass were not associated with the C825T variant. Finally, multivariate analyses accounting for potentially confounding factors failed to show any influence of this polymorphism on echocardiographic parameters. In conclusion, we were not able to confirm the previously published associations of the G protein ␤ 3 -subunit C825T polymorphism with LV structure and diastolic function.

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Blood pressure load determines left ventricular mass in essential hypertension

Cited by 36 publications

References 12 publications

Ambulatory blood pressure monitoring: mean blood pressure and blood pressure load

Ambulatory blood pressure monitoring: mean blood pressure and blood pressure load

Interventricular Septum Thickness Predicts Future Systolic Hypertension in Young Healthy Pilots

Relation of the G Protein β ₃ -Subunit Polymorphism With Left Ventricle Structure and Function

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Blood pressure load determines left ventricular mass in essential hypertension

Cited by 36 publications

References 12 publications

Ambulatory blood pressure monitoring: mean blood pressure and blood pressure load

Ambulatory blood pressure monitoring: mean blood pressure and blood pressure load

Interventricular Septum Thickness Predicts Future Systolic Hypertension in Young Healthy Pilots

Relation of the G Protein β 3 -Subunit Polymorphism With Left Ventricle Structure and Function

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Relation of the G Protein β ₃ -Subunit Polymorphism With Left Ventricle Structure and Function