Blood pressure levels and hypertension prevalence in a high selenium environment: results from a cross-sectional study

Chawla, Rajinder; Filippini, Tommaso; Dutt, Chaitanya; Cilloni, Silvia; Loomba, Rinchu; Bargellini, Annalisa; Orsini, Nicola; Dhillon, K. S.

doi:10.1016/j.numecd.2019.01.004

Cited by 43 publications

(17 citation statements)

References 46 publications

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“…While some studies indicate that suboptimal selenium is an independent risk factor for myocardial infarction (MI;Salonen et al 1982;Suadicani, Hein, and Gyntelberg 1992), others have not found this to be the case (Rayman 2000;Stranges et al 2006). A study by Lubos et al found an association of low selenium levels with increased risk of acute coronary syndrome but not with stable angina pectoris (Lubos et al 2010), while another study by Vinceti et al suggests that chronic overexposure to environmental selenium may increase blood pressure (Vinceti et al 2019). Evidence on the association between low selenium levels and increased mortality is also conflicting.…”

Section: Introductionmentioning

confidence: 99%

Selenium status in the body and cardiovascular disease: a systematic review and meta-analysis

Kuria

Tian

et al. 2020

Critical Reviews in Food Science and Nutrition

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Background: Both experimental and observational studies have provided conflicting evidence on the associations of selenium with incidence and mortality of cardiovascular disease (CVD). The aim of this study was to evaluate the association between selenium status in the body and incidence and mortality of CVD by performing a systematic review and meta-analysis of observational studies and randomized controlled trials. Methods: A systematic search for articles in MEDLINE (Ovid), Embase, Web of Science (Thomson Reuters) and Cochrane library (Wiley) was conducted. Thirteen of the 1811 articles obtained from the databases met our inclusion criteria and were considered in the final analysis. The effect sizes were presented as weighted relative risk (RR) and 95% confidence intervals (CIs) using random-effects model. To detect dose-response relationships, we used meta-regression. Results: Overall, there was a reduced risk of CVD incidence (RR ¼ 0.66; 95% CI: 0.40-1.09) and mortality (RR ¼ 0.69; 95% CI: 0.57-0.84) in physiologically high selenium status compared to low selenium status in the body. There was a 15% (RR ¼ 0.85, 95% CI: 0.76-0.94) decreased risk of CVD incidence per 10 mg increment in blood selenium concentration. In addition, a statistically significantly nonlinear dose-response relationship was found between CVD mortality and increased blood selenium concentration with the lowest risk at the 30-35 mg increment in blood selenium. Conclusions: Physiologically high selenium levels in the body are associated with decreased risk for CVD incidence and mortality, however, people should be cautious about the potential harmful effects from excessive intake of selenium.

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Section: Introductionmentioning

confidence: 99%

Selenium status in the body and cardiovascular disease: a systematic review and meta-analysis

Kuria

Tian

et al. 2020

Critical Reviews in Food Science and Nutrition

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“…In addition to its antioxidant (enhancing Gpx activity and selenoprotein synthesis) and pro-oxidant activities, it also exhibits a broad spectrum of biological functions including neuroprotection, immunomodulatory, anti-cancer [75]. Nevertheless, Se 2− overexposure (Se 2− toxicity) is also associated with various deleterious diseases like diabetic Mellitus, CVD, HT, neurological disorders [76]. A growing body of evidence suggests a strong relationship exists between serum Se 2− concentration and hypertension.…”

Section: Selenium (Se 2− )mentioning

confidence: 99%

“…Kuruppu and his colleagues [83], conducted a systemic review by compiling 25 clinical trial data and concluded that no strong association between blood Se levels and HT. A recent, cross-section study indicated that chronic environmental overexposure of Se could result in elevated BP, especially the women who are highly susceptible to Se 2− induce HT than men [76]. Lately, a nutritional examination survey conducted by Bastola and his co-workers [80], have inferred a positive association with the level of blood Se 2− and HT.…”

Section: Clinical Evidencementioning

confidence: 99%

Impact of Micronutrients on Hypertension: Evidence from Clinical Trials with a Special Focus on Meta-Analysis

et al. 2021

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Hypertension (HT) is one of the pivotal risk factors for various detrimental diseases like cardiovascular diseases (CVDs), cerebrovascular disease, and renal dysfunction. Currently, many researchers are paying immense attention to various diet formula (dietary approach) with a special focus on micro and macronutrients along with modified lifestyle and standard anti-hypertensive drugs. Micronutrients (minerals/vitamins) play a central role in the regulation of blood pressure (BP) as they aid the function of macronutrients and also improve the anti-hypertensive functions of some anti-hypertensive agents. Even though several studies have demonstrated the beneficial effects of micronutrients on controlling BP, still some ambiguity exists among the nutritionists/doctors, which combination or individual mineral (dietary approach) contributes to better BP regulation. Therefore, this critical review article was attempted to delineate the underlying role of micronutrients (minerals and vitamins) for the management and prevention or delaying of HT and their related complications with strong affirmation from clinical trials as well as its mechanism of controlling BP. Moreover, the major source and recommended daily allowance (RDA) of various micronutrients are included in this review for guiding common readers (especially HT subjects) and dieticians to choose/recommend a better micronutrient and their combinations (other nutrients and standard anti-hypertensive drugs) for lowering the risk of HT and its related co-morbid conditions like CVDs.

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“…Participants with low Se and high mercury serum levels were more likely to develop CVD, including hypertension (OR = 1.76), stroke (OR = 1.57), and heart attack (OR = 1.26). In contrast, other studies described a positive association between high Se REVIEW serum concentration and hypertension [83,84]. Based on the given research, the cardiovascular benefits of Se supplementation are unclear and should not be recommended.…”

Section: Se Supplementation In Adults and The Elderly Populationmentioning

confidence: 92%

The rationale for selenium supplementation in patients with autoimmune thyroiditis, according to the current state of knowledge

Filipowicz

Majewska

Kalantarova

et al. 2021

Endokrynologia Polska

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Selenium (Se) supplements are commonly prescribed to autoimmune thyroiditis (AIT) patients by European endocrinologists, despite the lack of official guidelines. The majority of Europe is depleted of natural Se sources, and the daily population intake does not comply with recommended values. Optimal individual plasma Se concentration is reached when the selenoproteins (selenoprotein P, glutathione peroxidase) are fully saturated. However, Se intake has to be regulated because both Se shortage and overdose negatively impact health. In the case of AIT, Se may alleviate symptoms or prevent progression to hypothyroidism and postpartum hypothyroidism. Se supplementation in euthyroid, subclinical, or overt hypothyroid AIT patients decreased thyroid autoantibodies, lowered or maintained the TSH level, decreased the fT4/fT3 ratio, reduced the body's oxidative stress and inflammatory status, and amended quality of life and thyroid ultrasound structure and volume. In pregnant females, adequate Se intake protected them against miscarriages, preeclampsia/hypertension, preterm birth, small-for-gestational-age infants' birth, and improved child's neuropsychological development. In the elderly population, adequate Se supplementation decreased cardiovascular diseases and hypertension risk, but prolonged intake of excessive doses increased the all-cause mortality rate. Routine Se supplementation implementation requires from researchers and clinicians consideration of specific populational differences in natural Se and iodine supply, the patient's clinical situation (supplementation simultaneously or before levothyroxine treatment, AIT/non-AIT hypothyroidism), individual response to supplementation (Se and selenoprotein P assessment), predisposition (genetic testing), the status of other trace elements, and the interplay between those micronutrients. Moreover, the safety of commercially available Se formulations, doses, and duration of treatment should be determined. Proper guidelines are warranted to standardise the medical approach to Se supplementation. This article presents a comprehensive review of recent randomised-controlled trials, meta-analyses, and clinical trials concerning the risks and benefits of Se supplementation in different clinical settings and specific populations with particular emphasis on AIT in a practical manner. (Endokrynol Pol 2021; 72 (2): 153-162)

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Blood pressure levels and hypertension prevalence in a high selenium environment: results from a cross-sectional study

Cited by 43 publications

References 46 publications

Selenium status in the body and cardiovascular disease: a systematic review and meta-analysis

Selenium status in the body and cardiovascular disease: a systematic review and meta-analysis

Impact of Micronutrients on Hypertension: Evidence from Clinical Trials with a Special Focus on Meta-Analysis

The rationale for selenium supplementation in patients with autoimmune thyroiditis, according to the current state of knowledge

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