Blood Pressure, Insulin, and C-Peplide Levels in San Luis Valley, Colorado

Every, Nathan R.; Boyko, Edward J.; Keane, Ellen; Marshall, Julie A.; Rewers, Marian; Hamman, Richard F.

doi:10.2337/diacare.16.12.1543

Cited by 25 publications

(13 citation statements)

References 39 publications

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“…Hyperinsulinemia and insulin resistance are associated with HTN [22][23][24][25]. Thus, incident HTN and serum ferritin level may be mediated by insulin resistance.…”

Section: Discussionmentioning

confidence: 96%

The incidental relationship between serum ferritin levels and hypertension

Ryoo

Kim

et al. 2015

International Journal of Cardiology

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“…Hyperinsulinemia and insulin resistance are associated with HTN [22][23][24][25]. Thus, incident HTN and serum ferritin level may be mediated by insulin resistance.…”

Section: Discussionmentioning

confidence: 96%

The incidental relationship between serum ferritin levels and hypertension

Ryoo

Kim

et al. 2015

International Journal of Cardiology

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“…This finding is consistent with the findings of some other investigators of other countries. [7][8][9][10]12 Elevated insulin level may alter blood pressure as it has effects on the sympathetic nervous system and renal sodium reabsorption. It has been suggested that sympathetic over activity may lead to structural changes in the microvasculature, which ultimately increases blood pressure and decreases peripheral glucose uptake.…”

Section: Discussionmentioning

confidence: 99%

“…11,12 The precise nature of the relationship between FSI level and essential hypertension remains still obscure. Therefore, this study has been designed to assess the insulin resistance in adult male with essential hypertension.…”

Section: -10mentioning

confidence: 99%

Correlation Study of Insulin Resistance and Essential Hypertension among Bangladeshi Male Volunteers

Sinha¹,

Akhter²,

Banik³

et al. 2015

JYP

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Background:The patients with essential hypertension are increasing all over the world. There may be development of insulin resistance and hyperinsulinemia in essential hypertension. An association between essential hypertension and defective insulin secretion has been identified. Insulin resistance is the fundamental defect in the development of type 2 diabetes mellitus, hypertension and cardiovascular diseases. Objective: To observe the insulin resistance in adult male with essential hypertension. Methods: This is a cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh from July 2012 to June 2013. A total number of 150 male subjects were selected with age ranging from 25-45 years. Seventy five male essential hypertensives were enrolled from Out-patient Department of Medicine, Dhaka Medical College Hospital, Dhaka. Otherwise healthy 75 of similar age were studied as control. Insulin resistance was assessed by HOMA-IR method. Fasting serum insulin level was measured by ELISA and fasting blood glucose by glucose oxidase method. Unpaired Student's 't' and Pearson's correlation coefficient (r) tests were performed for statistical analyses. Results: Current study reveals that essential hypertension has positive and significant relationship with fasting serum insulin level and insulin resistance. Conclusion: Incidence of insulin resistance is higher in essential hypertensive subjects in comparison to the control subjects. More in-depth prospective research is advocated to find remedies for common Bangladeshi patients.

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“…1,10,12,20,36,37 Insulin has been found to cause arteriosclerotic lesions and a proliferation of vascular smooth muscle cells and to promote renal tubular sodium and water absorption which may contribute to the development of cardiovascular disease. 1,10,37,38 Insulin resistance results in an increased hepatic glucose release, and a decreased catabolism of triglycerides contributing to an impaired glucose tolerance and to reduced HDL-cholesterol levels. 1,10 The metabolic complications of android obesity may be mediated by the more pronounced hyperinsulinaemia.…”

Section: Discussionmentioning

confidence: 99%

Impact of waist-hip-ratio and body-mass-index on hormonal and metabolic parameters in young, obese women

1997

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BACKGROUND: To investigate the impact of predominantly upper body fat localisation on the hormonal and metabolic pro®le in obese, infertile women. DESIGN: Prospective observational study of premenopausal women with obesity, infertility and menstrual dysfunction. SETTING: Department of Endocrinology and Reproduction of the University Hospital of Obstetrics and Gynaecology of Heidelberg. SUBJECTS: Eighteen women with android type obesity (waist-hip-ratio WHR b 0.85, group 1) and 22 women with gynoid type obesity (WHR 0.85, group 2) in a group of 58 premenopausal obese women (median age 28 y) with infertility. Twenty-nine women took part in a weight reducing program lasting 32 AE 14 (mean AE s.d.) weeks. MEASUREMENTS: BMI, WHR and blood pressure. Plasma lipids and liver enzymes. Blood glucose, insulin, C-peptide and different steroid and pituitary hormones during oral glucose loading. RESULTS: In the total group of 58 obese women, WHR was directly correlated to plasma triglycerides, AST, ALT and cholesterol/HDL-cholesterol-ratio. WHR correlated inversely with HDL-cholesterol. Insulin resistance was greater with increasing WHR. Systolic blood pressure, glucose, insulin, C-peptide, triglycerides, cholesterol/HDL-cholesterol-ratio, aspartate (AST) and alanine aminotransferase (ALT) were signi®cantly greater in group 1. Group 2 had greater HDLcholesterol levels. One subject in group 1, ®ve women in group 2 conceived spontaneously after weight reduction. CONCLUSIONS: Determination of the WHR is a simple measurement to identify obese patients who are at a greater risk of developing the metabolic syndrome. WHR is important in preventive medicine, as typical metabolic pro®les are already present in young women before clinical manifestation. Women with android obesity seem to be more prone to develop menstrual irregularity and infertility. The hyperinsulinaemia may be the pathway.

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Blood Pressure, Insulin, and C-Peplide Levels in San Luis Valley, Colorado

Abstract: Higher fasting insulin and C-peptide levels are associated with higher blood pressure, but these relationships are modified by sex and degree of obesity.

Cited by 25 publications

References 39 publications

The incidental relationship between serum ferritin levels and hypertension

The incidental relationship between serum ferritin levels and hypertension

Correlation Study of Insulin Resistance and Essential Hypertension among Bangladeshi Male Volunteers

Impact of waist-hip-ratio and body-mass-index on hormonal and metabolic parameters in young, obese women

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