Blood Pressure in Relation to Environmental Lead Exposure in the National Health and Nutrition Examination Survey 2003 to 2010

Hara, Azusa; Thijs, Lutgarde; Asayama, Kei; Gu, Yuxuan; Jacobs, Lotte; Zhang, Zhen Yu; Liu, Yan Ping; Nawrot, Tim S.; Staessen, Jan A.

doi:10.1161/hypertensionaha.114.04023

Cited by 62 publications

(51 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hara showed that the low levels of lead that exist today in the USA have little influence on blood pressure 30. As a national randomly sampled, non-institutionalised civilian study, it is significant that the association between log BLL and blood pressures was investigated in non-smoking healthy Koreans.…”

Section: Discussionmentioning

confidence: 99%

Association between blood lead levels and blood pressures in a non-smoking healthy Korean population

Lee

Hwang

et al. 2016

Postgraduate Medical Journal

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Association between blood lead levels and blood pressures in a non-smoking healthy Korean population

Lee

Hwang

et al. 2016

Postgraduate Medical Journal

View full text Add to dashboard Cite

show abstract

“…A meta-analysis of the epidemiological studies available from 1980 to 2001 reported that a 2-fold increase in blood lead concentration was associated with a 1.0 mm Hg increase in systolic blood pressure and a 0.6 mm Hg increase in diastolic blood pressure [11]. Recent data have suggested that the effect sizes in the associations of blood pressure and blood lead (mean of 1.51 μg/dL) are small and inconsistent [6], or that a modest association was found [12]. …”

Section: Introductionmentioning

confidence: 99%

Association between blood lead and blood pressure: a population-based study in Brazilian adults

et al. 2017

View full text Add to dashboard Cite

BackgroundEnvironmental lead exposure among adults may increase blood pressure and elevate the risk of hypertension. The availability of data on blood lead levels (BLL) in adult Brazilian population is scarce and population-based studies are important for screening the population exposure and also to evaluate associations with adverse health effects. The goal of this study was to examine the association of BLL with blood pressure and hypertension in a population-based study in a city in Southern Brazil.MethodsA total of 948 adults, aged 40 years or older, were randomly selected. Information on socioeconomic, dietary, lifestyle and occupational background was obtained by orally administered household interviews. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured according to the guidelines VI Brazilian Guidelines on Hypertension. BLL were measured by inductively coupled plasma mass spectrometry technique. Multiple linear and logistic regression models were performed to evaluate associations of BLL with SBP and DBP, and with the chance of hypertension and of elevated SBP and DBP.ResultsThe geometric mean of BLL was 1.97 μg/dL (95%CI:1.90-2.04 μg/dL). After multivariable adjustment, participants in the quartile 4 of blood lead presented 0.06 mm/Hg (95%CI, 0.04-0.09) average difference in DBP comparing with those in quartile 1. Participants in the 90th percentile of blood lead distribution had 0.07 mmHg (95% CI, 0.03 to 0.11) higher DBP compared with those participants in the 10th percentile of blood lead. The adjusted OR for hypertension was 2.54 (95% CI, 1.17-5.53), comparing the highest to the lowest blood lead quartiles. Compared with participants in the 10th percentile of blood lead, participants in the 90th percentile presented higher OR for hypertension (OR: 2.77; 95% CI, 1.41 to 5.46).ConclusionAt low concentrations, BLL were positively associated with DBP and with the odds for hypertension in adults aged 40 or older. It is important to enforce lead exposure monitoring and the enactment of regulatory laws to prevent lead contamination in urban settings.

show abstract

“…12 Most of these studies contrasted blacks from African ancestry with whites in the United States. However, we recently reported that the prevalence of hypertension on conventional BP measurement, amounted to 13.3% and 28.9%, respectively, among South Africans and Flemish whites and to 34.1% among black South Africans.…”

mentioning

confidence: 99%

Prevalence and Determinants of Masked Hypertension Among Black Nigerians Compared With a Reference Population

et al. 2016

Self Cite

View full text Add to dashboard Cite

Abstract-Hitherto, diagnosis of hypertension in sub-Saharan Africa was largely based on conventional office blood pressure (BP). Data on the prevalence of masked hypertension (MH) in this region is scarce. Among individuals with normal office BP (<140/90 mm Hg), we compared the prevalence and determinants of MH diagnosed with self-monitored home blood pressure (≥135/85 mm Hg) among 293 Nigerians with a reference population consisting of 3615 subjects enrolled in the International Database on Home Blood Pressure in Relation to Cardiovascular Outcomes. In the reference population, the prevalence of MH was 14.6% overall and 11.1% and 39.6% in untreated and treated participants, respectively. Among Nigerians, the prevalence standardized to the sex and age distribution of the reference population was similar with rates of 14.4%, 8.6%, and 34.6%, respectively. The mutually adjusted odds ratios of having MH in Nigerians were 2.34 (95% confidence interval, 1.39-3.94) for a 10-year higher age, 1.92 (1.11-3.31) and 1.70 (1.14-2.53) for 10-or 5-mm Hg increments in systolic or diastolic office BP, and 3.05 (1.08-8.55) for being on antihypertensive therapy. The corresponding estimates in the reference population were similar with odds ratios of 1.80 (1.62-2.01), 1.64 (1.45-1.87), 1.13 (1.05-1.22), and 2.84 (2.21-3.64), respectively. In conclusion, MH is as common in Nigerians as in other populations with older age and higher levels of office BP being major risk factors. A significant proportion of true hypertensive subjects therefore remains undetected based on office BP, which is particularly relevant in sub-Saharan Africa, where hypertension is now a major cause of death.

show abstract

Blood Pressure in Relation to Environmental Lead Exposure in the National Health and Nutrition Examination Survey 2003 to 2010

Abstract: Abstract-In view of the declining environmental lead exposure in the United States, we analyzed the National Health and Nutrition Examination Survey (2003-2010)

Cited by 62 publications

References 20 publications

Association between blood lead levels and blood pressures in a non-smoking healthy Korean population

Association between blood lead levels and blood pressures in a non-smoking healthy Korean population

Association between blood lead and blood pressure: a population-based study in Brazilian adults

Prevalence and Determinants of Masked Hypertension Among Black Nigerians Compared With a Reference Population

Contact Info

Product

Resources

About