Blood pressure distribution in a Hungarian adolescent population

Páll, Dénes; Katona, Éva; Fülesdi, Béla; Zrı́nyi, Miklós; Zatik, János; Bereczki, Dániel; Polgár, Péter; Kakuk, G.

doi:10.1097/00004872-200301000-00012

Cited by 36 publications

(40 citation statements)

References 21 publications

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“…Patients: 106 healthy and hypertensive adolescents were included from the Debrecen Hypertension Study [15] . The recruitment of the subjects and the methods for proving or excluding hypertension in the population consisting of 10,359 adolescents were described earlier in detail [15] .…”

Section: Methodsmentioning

confidence: 99%

Both Nitric Oxide and Endothelin-1 Influence Cerebral Blood Flow Velocity at Rest and after Hyper- and Hypocapnic Stimuli in Hypertensive and Healthy Adolescents

Katona

Settakis

Varga

et al. 2006

Kidney Blood Press Res

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Background and Purpose: Nitric oxide (NO)/endothelin imbalance may play a role in the regulation of cerebral blood flow. The aim of the present study was to assess whether these endothelial factors influence middle cerebral artery blood flow velocities (MCAV) and cerebrovascular reactivity (CVR) in healthy and hypertensive adolescents. Subjects and Methods: 106 adolescents (61 hypertensive and 45 normotensive) underwent transcranial Doppler measurements of the middle cerebral artery at rest and after 30 s of breath-holding (BH) and 60 s of hyperventilation (HV). Additionally, NO and endothelin-1 (ET-1) concentrations of the serum were assessed. The correlation between NO and ET-1 levels as well as MCAV and CVR values was analyzed. Results: Resting MCAVs were higher among hypertensive teenagers (76.5 ± 24 vs. 62.8 ± 15.6 cm/s, respectively, p < 0.001). CVR values did not differ between hypertensive and healthy adolescents after the BH and HV procedure. A significant negative correlation was found between absolute MCAV values and NO concentrations. ET-1 was positively related to MCAV. Conclusions: Cerebral blood flow velocities, but not CVR values, are associated with serum NO and ET-1 concentrations in adolescents.

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Section: Methodsmentioning

confidence: 99%

Both Nitric Oxide and Endothelin-1 Influence Cerebral Blood Flow Velocity at Rest and after Hyper- and Hypocapnic Stimuli in Hypertensive and Healthy Adolescents

Katona

Settakis

Varga

et al. 2006

Kidney Blood Press Res

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“…However, current charts are based on a US population and unlikely to be valid throughout the rest of the world (Materson, 2003). A study showed that there are geographical and ethnic variations in blood pressure in adolescents, indicating that acceptance and use of nonpopulation-specific blood pressure distribution may lead to under-or overdiagnosis of hypertension (Pall et al, 2003). In Taiwan, there remain no published cut-points for hypertension in children and adolescents currently and the government have adopted the adult criteria of 140/90 mmHg (Taiwan Department of Health, 2004).…”

Section: Obesity and Physical Fitnessmentioning

confidence: 99%

Obesity, fitness and health in Taiwanese children and adolescents

et al. 2006

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Objective: To examine the prevalence of childhood and adolescent obesity in Taiwan and investigate the association between excess weight and physical fitness and blood pressure. Design: Cross-sectional study. Subjects: A total of 13 935 children and adolescents aged 6-18 years (boys: 7031, girls: 6904) were involved in the 1999 survey and 24 586 (boys: 12 367, girls: 12 219) were available in the 2001 survey. Measurements: Weight, height, systolic and diastolic blood pressures, and health-related fitness tests (bent-leg curl-ups, sit-and-reach test and step test) were measured. Results: The overall prevalence of obesity (including overweight) in boys was 19.8% in 1999 and 26.8% in 2001. It was lower in girls with 15.2% in 1999 and 16.5% in 2001. The normal weight group performed better (Po0.05) than the overweight/obese group in all fitness tests except in the 2001 sit-and-reach test where there were no differences between the two groups. The risk of hypertension increased nearly two times for the overweight/obese-fit group and nearly three times for the overweight/ obese-unfit group compared to the normal weight-fit group (adjusted odds ratio (AOR) ¼ 1.93, 95%CI ¼ 1.514-2.451 and AOR ¼ 2.93, 95%CI ¼ 2.493-3.454, respectively). Conclusion: Overall, the findings demonstrated that there is an increasing trend in overweight/obesity prevalence for Taiwanese youth even in a 2-year period. The overweight/obese youngsters tend to have poorer muscular strength and cardiovascular endurance than the normal weight group. The overweight/obese and unfit group had a greater risk of hypertension than other groups. However, this risk was significantly lower if obese/overweight children had a higher than average level of cardiovascular fitness.

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“…This was a part of a population-based screening program which aimed to assess the prevalence and the influencing factors of adolescent hypertension in Debrecen, a city of 230,000 inhabitants [17] . At baseline investigations, 10,359 subjects underwent three consecutive blood pressure measurements (Omron M4 digital oscillometry manometer; Omron, Healthcare GmbH, Hamburg, Germany).…”

Section: Methodsmentioning

confidence: 99%

“…It is believed that early diagnosis and proper treatment decreases the incidence of secondary organ damage caused by hypertension. For assessing cerebral hemodynamics in adolescents, we included patients and control subjects from the population-based cohort of the Debrecen Hypertension Study [17] in order to answer the following two questions: Can we detect differences between cerebral blood flow velocities of healthy and hypertensive adolescents? Is there any difference between cerebral vasoreactivity of healthy and hypertensive teenagers as measured during hyperventilation tests?…”

Section: Introductionmentioning

confidence: 99%

Hyperventilation-Induced Cerebrovascular Reactivity among Hypertensive and Healthy Adolescents

Settakis

Páll

Molnár

et al. 2006

Kidney Blood Press Res

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Background: It is known that cerebral vasoreactivity is altered in adult arterial hypertension but no information is available about cerebral arteriolar function in hypertensive adolescents. Therefore, the aim of the present work was to assess cerebral vasoreactivity responses in adolescent hypertension. Methods: 113 hypertensive and 58 normotensive adolescents were assessed with transcranial Doppler sonography by using voluntary hyperventilation (HV) as vasoconstrictory stimulus. Absolute blood flow velocities (systolic, mean and diastolic) and pulsatility indices (PIs) at rest and after HV, as well as percentage change of the blood flow velocities after HV were compared among the groups. Results: Blood flow velocities at rest were significantly higher in hypertensive individuals, while PIs were similar in the two groups. After HV, all blood flow velocity parameters were higher among hypertensive teenagers than in healthy controls, while PIs did not differ between the two groups. Taking the relative changes after HV into account, it was found that HV induced a more pronounced change of the systolic and mean blood flow velocities of the control subjects than in hypertensive adolescents. Conclusions: Cerebrovascular reactivity to hypocapnia is decreased in hypertensive adolescents as compared to healthy teenagers. Further studies are needed to clarify the clinical significance of altered cerebral microvascular function in adolescent hypertension.

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Blood pressure distribution in a Hungarian adolescent population

Cited by 36 publications

References 21 publications

Both Nitric Oxide and Endothelin-1 Influence Cerebral Blood Flow Velocity at Rest and after Hyper- and Hypocapnic Stimuli in Hypertensive and Healthy Adolescents

Both Nitric Oxide and Endothelin-1 Influence Cerebral Blood Flow Velocity at Rest and after Hyper- and Hypocapnic Stimuli in Hypertensive and Healthy Adolescents

Obesity, fitness and health in Taiwanese children and adolescents

Hyperventilation-Induced Cerebrovascular Reactivity among Hypertensive and Healthy Adolescents

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