Blood pressure and risk of cancer progression – A possible connection with salt and voltage-gated sodium channel

Djamgoz, Mustafa B.A.

doi:10.1016/j.mehy.2015.07.021

Cited by 8 publications

(8 citation statements)

References 25 publications

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“…The association of salt intake to total mortality and noncardiovascular (mostly cancer) deaths in the Singer study is particularly important, given the long length of follow‐up. It strengthens the evidence from previous associations of salt intake to gastric and renal cell cancer and relates to biomedical mechanisms of higher salt intake promoting cancer …”

Section: Discussionsupporting

confidence: 85%

“…It strengthens the evidence from previous associations of salt intake to gastric and renal cell cancer and relates to biomedical mechanisms of higher salt intake promoting cancer. [31][32][33][34] The systematic review excluded many studies based on failure to achieve our quality criteria. Low-quality research methods (including short duration studies, clinically insignificant reductions in salt intake, flawed measurement methods such as spot urine samples to measure long-term individual salt intake, and cohort studies in people with disease) have resulted in controversy over the impact of changing dietary salt on health.…”

Section: Discussionmentioning

confidence: 99%

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The Science of Salt: A Systematic Review of Quality Clinical Salt Outcome Studies June 2014 to May 2015

Johnson

Thout

Trieu

et al. 2016

J of Clinical Hypertension

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) on the impact of dietary salt intake on clinical and population health are reviewed. Randomized controlled trials, cohort studies, and meta-analyses of these study types on the effect of sodium intake on blood pressure, or any substantive adverse health outcomes were identified from MEDLINE searches and quality indicators were used to select studies that were relevant to clinical and public health. From 6920 studies identified in the literature search, 144 studies were selected for review, of which only three In addition to the adverse effects of salt on BP and vascular risk, a range of other serious health problems are also implicated including gastric cancer and osteoporosis.3 On the basis of the evidence linking salt, BP, and vascular risk, the World Health Organization (WHO) recommends that all member states implement a salt reduction program. A 30% lowering in mean population salt intake by 2025 has been included as one of the targets of the "25 by 25" World Health Assembly/WHO initiative for the control of noncommunicable diseases.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

The Science of Salt: A Systematic Review of Quality Clinical Salt Outcome Studies June 2014 to May 2015

Johnson

Thout

Trieu

et al. 2016

J of Clinical Hypertension

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“…Increased BP is a leading preventable risk factor for heart disease (heart attack and heart failure), stroke, and kidney failure and a major contributor to premature death, dementia, disability, and healthcare costs Other diseases that have been associated with high salt intake include gastric cancer (probable procarcinogen), total cancer, recurrent kidney stones (causal association), osteoporosis, obesity, fatty liver, headache, multiple sclerosis, rheumatoid arthritis, cataracts, infertility, and direct renal, and vascular and cardiac damage …”

Section: Diets High In Salt (Sodium) Are Associated With a High Burdementioning

confidence: 99%

“…2 Other diseases that have been associated with high salt intake include gastric cancer (probable procarcinogen), total cancer, recurrent kidney stones (causal association), osteoporosis, obesity, fatty liver, headache, multiple sclerosis, rheumatoid arthritis, cataracts, infertility, and direct renal, and vascular and cardiac damage. [3][4][5][6][7][8][9][10][11]…”

mentioning

confidence: 99%

2016 Dietary Salt Fact Sheet and Call to Action: The World Hypertension League, International Society of Hypertension, and the International Council of Cardiovascular Prevention and Rehabilitation

Campbell

Lackland

Niebylski

et al. 2016

J of Clinical Hypertension

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The Global Burden of Disease Study estimated that there were 3.7 million deaths, 68 million years of life lost, and 74 million years of disability as a result of excess dietary salt in 2013. (Institute for Health Metrics and Evaluation, http://vizhub.healthdata.org/gbd-compare/. Accessed December 22, 2015.) One half of blood pressure (BP)-related disease occurs in people with raised BP within the normal range. However, high dietary salt increases BP in this normal range and in patients with hypertension. High dietary salt causes an estimated 30% of hypertension or over 300 million people to have hypertension.

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“…Several studies have demonstrated numerous changes in various organs which result from ischemia in hypertension (Cohuet et al, 2006;Hsueh et al, 1992). It has been also shown that high blood pressure increases the ability of tumors to metastasize (Djamgoz, 2015;Li et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Changes in the pancreas caused by different types of hypertension

Nowińska

2017

Acta Biochim Pol

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Hypertension is considered a lifestyle disease. Unfavorable forecasts predict a significant increase in the number of patients suffering from this disorder. Many changes in various organs have been observed as a result of ischemia. An interesting question arises of whether differences between the mechanisms occurring in different types of hypertension could produce different effects in the organs. It is well known that there is a close relationship between hypertension and insulin resistance. On the other hand, insulin resistance is the main cause of type 2 diabetes, which develops in parallel with changes in the pancreas. The pancreas is a very important organ since it produces enzymes crucial for the digestive process, as well as performs an important endocrine function. The work presented here focuses primarily on the latter issue. The authors present an overview of contemporary literature concerning the influence of different types of hypertension on the function of the pancreas.

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Blood pressure and risk of cancer progression – A possible connection with salt and voltage-gated sodium channel

Cited by 8 publications

References 25 publications

The Science of Salt: A Systematic Review of Quality Clinical Salt Outcome Studies June 2014 to May 2015

The Science of Salt: A Systematic Review of Quality Clinical Salt Outcome Studies June 2014 to May 2015

2016 Dietary Salt Fact Sheet and Call to Action: The World Hypertension League, International Society of Hypertension, and the International Council of Cardiovascular Prevention and Rehabilitation

Changes in the pancreas caused by different types of hypertension

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