Blood Pressure and Heart Rate in the Turkey as Measured by the Indirect Method and their Modifications by Pharmacological Agents

Krista, L. M.; Burger, Ray E.; Waibel, P. E.

doi:10.3382/ps.0420646

Cited by 26 publications

(17 citation statements)

References 5 publications

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“…As previously reported in other studies (13,14,29), in untreated Broad Breasted White Turkeys a progressive rise in blood pressure levels and a decrease in heart rate occur with ageing. In this strain of turkey, systolic blood pressure is higher than in any other experimental animal (10) and responds to the same drugs commonly used in human hypertension, including ~-blockers (29), reserpine (26), hydralazine (27), and captopril (28).…”

Section: Discussionsupporting

confidence: 61%

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Ventricular myosin pattern of spontaneously hypertensive turkeys is unaffected by labetalol treatment

Pauletto

Vescovo²,

Scannapieco³

et al. 1988

Basic Res Cardiol

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In most animal species, left ventricular hypertrophy due to pressure overload is associated with an advantageous increase of the "slow" V3 isomyosin. In contrast, in spontaneously hypertensive turkeys, the development of left ventricular hypertrophy is associated with the synthesis of a "fast" V1-like isomyosin, with high incidence of cardiac failure. This could be related to the high catecholamine levels found in these animals. This is why we studied the ventricular myosin pattern after lowering of blood pressure and regression of cardiac hypertrophy obtained by means of labetalol, and alpha- and beta-blocking drug which inhibits the effects of catecholamines. From the 2nd to the 32nd week of age, 22 turkeys were treated with increasing doses of p.o. labetalol (from 20 to 35 mg/kg body weight daily) and 16 other turkeys were given daily p.o. placebo. Blood pressure and heart rate were periodically measured by an indirect method. After sacrifice, the degree of cardiac hypertrophy was evaluated by the biventricular weight to body weight ratio, ventricular myosin was purified, Ca++-activated ATPase activity assessed, and ventricular myosin pattern was determined by two-dimensional gel electrophoresis of myosin heavy chains. Plasma and cardiac catecholamines were measured by high performance liquid chromatography. Throughout the study period, blood pressure and heart rate were significantly reduced in the labetalol-treated animals as compared to the untreated ones. At the end of the study period, the ventricular mass was significantly lower in the labetalol group. Nevertheless, no differences were observed in ventricular myosin pattern and Ca++-activated ATPase activity levels between the two groups. In the labetalol group, an increase in plasma catecholamines and only a slight, but not significant, increase in cardiac catecholamines was found. These data indicate that in spontaneously hypertensive turkeys, the synthesis of the "fast" V1-like isomyosin is not influenced by known pathophysiological stimuli like blood pressure, cardiac hypertrophy and catecholamines.

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Section: Discussionsupporting

confidence: 61%

“…All animals were weighed every week. Blood pressure and heart rate were measured every 5 weeks using an indirect method (13). Before sacrifice, blood samples were drawn to determine plasma catecholamine levels and for routine biochemical assays.…”

Section: Methodsmentioning

confidence: 99%

Ventricular myosin pattern of spontaneously hypertensive turkeys is unaffected by labetalol treatment

Pauletto

Vescovo²,

Scannapieco³

et al. 1988

Basic Res Cardiol

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“…During the starting and growing periods turkeys were fed diet series 3 (see Krista et al, 1969). The blood pressure readings of the progeny were recorded at 8 weeks of age (method described by Krista et al, 1963). Individual body weights were recorded at 6 weeks of age.…”

Section: Methodsmentioning

confidence: 99%

Strain Crosses Within and Between Lines of Turkeys Selected for High and Low Blood Pressure

et al. 1971

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“…A cuff designed for laying hens one inch in width was employed to occlude the artery. The procedure was described by Krista et al (1963).…”

Section: Introductionmentioning

confidence: 99%

A Study of Aortic Rupture and Performance as Influenced by Selection for Hypertension and Hypotension in the Turkey

et al. 1970

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Blood Pressure and Heart Rate in the Turkey as Measured by the Indirect Method and their Modifications by Pharmacological Agents

Abstract: Deficiencies in over-heated soybean oil meal. Poultry Sci. 26: 150-156. Fraenkel-Conrat, H., and M. Cooper, 1944. The use of dyes for the determination of acid and basic groups in proteins.

Cited by 26 publications

References 5 publications

Ventricular myosin pattern of spontaneously hypertensive turkeys is unaffected by labetalol treatment

Ventricular myosin pattern of spontaneously hypertensive turkeys is unaffected by labetalol treatment

Strain Crosses Within and Between Lines of Turkeys Selected for High and Low Blood Pressure

A Study of Aortic Rupture and Performance as Influenced by Selection for Hypertension and Hypotension in the Turkey

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