Blood pool activity on F-18 FDG PET/CT as a possible imaging biomarker of metabolic syndrome

Abstract

Association of blood pool (BP) and adipose tissue activity from F-18 fluorodeoxyglucose positron-emission tomography/computed tomography (FDG PET/CT) with the parameters of metabolic syndrome (MetS) and different MetS/obesity types were investigated. 245 subjects underwent FDG PET/CT scan for health check-ups were investigated retrospectively. Associations of BP (BP SUV: SUVmax, SUVmean), visceral (VAT SUV), and subcutaneous adipose tissue (SAT SUV) activity with parameters of MetS, body mass index (BMI), and lipid profiles were analyzed. MetS/obesity types were subdivided into metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO). BP SUV was higher in subjects with MetS (t-test, P < 0.005), and was associated with MetS from multivariable binary logistic regression (OR 5.232 P = 0.010). BP SUV was statistically higher in MUO than in MHO (P < 0.05) along with blood pressure, triglycerides, and HDL-cholesterol. Multivariable binary logistic regression analysis showed MUO had higher blood pressure and BP SUV, while lower HDL-cholesterol relative to MHO after adjusting for triglycerides.

Changes of macrophage and CD4+ T cell in inflammatory response in type 1 diabetic mice

“…Spleen is an important peripheral immune organ, where most of the immune cells proliferate. And the change of the proportion of immune cells in the spleen can reflect the immune state of DM mice to some extent 19 , 20 , so we used flow cytometry to measure the ratio of CD4 + T cells and their subtypes in normal and DM groups. Compared with normal mice, the proportion of pro-inflammatory CD4 + T subtypes, Th1 cells and Th17 cells in DM group was significantly increased, and the proportion of Tregs cells and Th2 cells was significantly decreased (Fig.…”

“…In our research, the change of CD4 + T cells positively correlates with macrophages in pancreas, these results could suggest the relationship between CD4+ T cells and macrophages during the progress of T1DM. As an important peripheral immune organ, most immune cells proliferate in the spleen, and the change in the proportion of immune cells in the spleen can reflect the inflammatory reaction of DM mice to some extent 19 , 20 . According to the results, the proportion of CD4 + T cells and macrophages in the DM group was higher than that in the normal group, which was related to the increased mobilization of immune cells in the spleen during the inflammatory reaction.…”