Blood Platelet 5-Hydroxytryptamine Levels in Psychiatric Patients

Todrick, A.; Tait, A. C.; Marshall, Elizabeth F.

doi:10.1192/bjp.106.444.884

Cited by 34 publications

(12 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies found no differences in the blood serotonin of nonsuicidal schizophrenic or schizoaffective patients when compared to healthy subjects [33,34,37], but high blood serotonin levels [30,38,39] were also noted; no difference in blood or platelet serotonin concentrations was reported between nonsuicidal unipolar depressed and healthy subjects [30,36,[40][41][42][43]. The suicidal depressed and schizophrenic patients of our study were more chronically ill than patients with adjustment disorder; therefore both chronicity and suicidal behavior may be associated with the altered serotonergic function in these patients.…”

Section: Discussionmentioning

confidence: 99%

Upregulation of the Platelet Serotonin<sub>2A</sub> Receptor and Low Blood Serotonin in Suicidal Psychiatric Patients

et al. 1998

View full text Add to dashboard Cite

Suicidality has been found to be associated with low pre- and postsynaptic serotonin functioning. The purpose of this study was to examine whether in acutely suicidal psychiatric inpatients, the blood serotonin concentration was related to the underlying psychiatric disorder and whether it was associated with changes in the affinity (dissociation constant, K_D) or in the maximal binding capacity (B_max) of the platelet serotonin_2A receptor. We therefore determined the blood serotonin concentrations and the platelet serotonin_2A receptor activities of 45 suicidal psychiatric patients and 20 healthy subjects. We found that the blood serotonin concentrations were significantly lower in suicidal patients compared to healthy subjects. In all diagnostic categories (affective disorder, schizophrenia and adjustment disorder) we noted a significantly higher maximal binding capacity of the platelet serotonin_2A receptor. These findings support the notion that a reduction in the availability of serotonin and an upregulation of the serotonin_2A receptors in psychiatric patients are associated with a loss of control over suicidal impulses.

show abstract

Section: Discussionmentioning

confidence: 99%

Upregulation of the Platelet Serotonin<sub>2A</sub> Receptor and Low Blood Serotonin in Suicidal Psychiatric Patients

et al. 1998

View full text Add to dashboard Cite

show abstract

“…and its metabolite, 5-hydroxyindoleactic acid (5-HIAA), in the blood and CSF of depressed patients were reported to be relatively low in comparison with those observed in healthy volunteers (Coppen et al, 1976;Banki, 1978;Asberg et al, 1984;Quan-Bui et al, 1984;Quintana, 1992) but unchanged or higher in other studies (Todrick et al, 1960;Stahl et al, 1983;Roy et al, 1985;Meltzer and Arora, 1986;Muck-Seler et al, 1991;Reddy et al, 1992). Studies on the 5-HT levels in postmortem brain tissues of depressed patients are less common and also yielded conflicting results (Cheetham et al, 1989).…”

mentioning

confidence: 94%

High Serotonin and 5‐Hydroxyindoleacetic Acid Levels in Limbic Brain Regions in a Rat Model of Depression; Normalization by Chronic Antidepressant Treatment

Zangen

Overstreet

Yadid

1997

Journal of Neurochemistry

160

View full text Add to dashboard Cite

Although alterations in serotonin levels and neurotransmission are associated with depressive disorders and effective antidepressant therapy, the exact cause of these disorders and the mode of action of anti‐depressant drugs are poorly understood. In a genetic rat model of depression [Flinders sensitive line (FSL) rats], deviations from normal serotonin (5‐HT) levels and metabolism in specific brain regions were determined. The levels of 5‐HT and its metabolite, 5‐hydroxyindoleacetic acid (5‐HIAA), in tissue punches of various brain regions were quantitated simultaneously with an HPLC apparatus coupled to an electrochemical detector. In the nucleus accumbens, prefrontal cortex, hippocampus, and hypothalamus of FSL rats, the levels of 5‐HT and 5‐HIAA were three‐ to eightfold higher than in control Sprague‐Dawley rats. Significant differences in the levels of 5‐HT and 5‐HIAA in the striatum and raphe nucleus of the “depressed” and normal rats were not observed. After chronic treatment with the antidepressant desipramine (5 mg/kg/day for 18 days), the immobility score in a swim test, as a measure of a behavioral deficit, and 5‐HT levels of the FSL rats became normalized, but these parameters in the control rats did not change. The [5‐HIAA]/[5‐HT] ratio was lower in the nucleus accumbens and hypothalamus of the FSL than in the control rats, and increased after desipramine treatment only in the nucleus accumbens of the FSL rats. These results indicate that the behavioral deficits expressed in the FSL model for depression correlate with increased 5‐HT levels in specific limbic sites and suggest the FSL rats as a novel model for clarification of the molecular mechanism of clinically used antidepressant drugs.

show abstract

“…4 Using platelets as model cells to study neuropathology is concept that has been noted by several researchers since the early 1960s (see Table I). [5][6][7][8][9] There are many studies providing evidence to propose blood platelets as a model of bioaminergic neurons. 10 Similarities between platelets and neurons have been found to be particularly important with respect to serotonin metabolism, 11 but this model can also be extended to other neurotransmitters such as dopamine, 8,12 gamma-aminobutyric acid (GABA), and glutamate.…”

mentioning

confidence: 99%

The contribution of platelet studies to the understanding of disease mechanisms in complex and monogenetic neurological disorders

Goubau

Buyse

Geet

et al. 2014

Develop Med Child Neuro

View full text Add to dashboard Cite

Platelets, known for their role in primary haemostasis, prevent excessive bleeding after injury. The study of platelets has, therefore, traditionally focused on bleeding disorders. It has recently become evident, however, that platelet research can contribute to unravelling the disease mechanisms that underlie neuropathological disorders that have a subtle subclinical platelet phenotype. Platelets and neurosecretory cells have common gene expression profiles and share several biological features. This review provides a literature update on the use of platelets as easily accessible cells to study neurological disorders. We provide examples of the use of different platelet‐based tests to understand the underlying pathophysiological mechanisms for both complex and monogenetic neuropathological disorders. In addition to the well‐studied regulated granule secretion and serotonin metabolism, more recent studies have shown that defects in transcription factors, membrane transporters, G‐protein signal transduction, and cytoskeletal proteins can be investigated using platelets to gain information on their role in neuropathology.

show abstract

Blood Platelet 5-Hydroxytryptamine Levels in Psychiatric Patients

Cited by 34 publications

References 15 publications

Upregulation of the Platelet Serotonin<sub>2A</sub> Receptor and Low Blood Serotonin in Suicidal Psychiatric Patients

Upregulation of the Platelet Serotonin<sub>2A</sub> Receptor and Low Blood Serotonin in Suicidal Psychiatric Patients

High Serotonin and 5‐Hydroxyindoleacetic Acid Levels in Limbic Brain Regions in a Rat Model of Depression; Normalization by Chronic Antidepressant Treatment

The contribution of platelet studies to the understanding of disease mechanisms in complex and monogenetic neurological disorders

Contact Info

Product

Resources

About