Blood plasma protein adsorption capacity of perfluorocarbon emulsion stabilized by proxanol 268 (in vitro and in vivo Studies)

Sklifas, A. N.; Zhalimov, V. K.; Temnov, A. A.; Kukushkin, N. I.

doi:10.1134/s0006350912020212

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…Blood proteins also influence the penetration of drugs into tissues [11-13] and drug elimination and metabolism [14,15]. Changes of free drug concentrations due to hypoalbuminaemia can dramatically influence the therapeutic effects and induce side-effects [16].…”

Section: Introductionmentioning

confidence: 99%

Effect of blood protein concentrations on drug-dosing regimes: practical guidance

Gurevich

2013

Theor Biol Med Model

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In this article the importance of blood proteins for drug dosing regimes is discussed. A simple mathematical model is presented for estimating recommended drug doses when the concentration of blood proteins is decreased. Practical guidance for drug dosing regimes is discussed and given in the form of a figure. It is demonstrated that correction of drug dosing regimes is needed only for when there is a high level of drug conjugation with blood proteins and a high degree of hypoalbuminaemia. An example of the use of this model is given.

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Section: Introductionmentioning

confidence: 99%

Effect of blood protein concentrations on drug-dosing regimes: practical guidance

Gurevich

2013

Theor Biol Med Model

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“…In PFCE, the perfluorocarbon (PFC) drops are coated with a layer of triblock copolymer (130PEG-38PPG-130PEG). Our early studies showed that PFCE can adsorb significant amount of proteins which mainly consists of immunoglobulins and various lipoproteins [ 5 6 ]. It is impossible to use this emulsion as an adjuvant directly.…”

mentioning

confidence: 99%

“…The second part should be target antigen. We believe that a plausible candidate for the first part is apolipoprotein A-I (ApoAI) which as shown earlier is strongly adsorbed on the surface of the emulsion [ 5 6 ].…”

mentioning

confidence: 99%

The effect of apolipoprotein A-I and perfluorocarbon emulsion on the production of specific antibodies in mice

Zhalimov

Gritsyna

Morenkov

2021

Clin Exp Vaccine Res

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Adjuvants are often required to improve the potentially low immunogenicity of vaccines. In this study, it is proposed to use an emulsion based on fluorocarbons as an adjuvant. Since this emulsion adsorbs only a small range of proteins, apolipoprotein A-I (ApoAI) was used as an anchor. Antigen and ApoAI were combined by creating a fusion construct. Results showed that the combined use of a perfluorocarbon emulsion and ApoAI during immunization significantly increases the specific antibody titer in mice and in its effectiveness this system is close to the incomplete Freund's adjuvant.

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Nanoparticles of perfluorocarbon emulsion contribute to the reduction of methemoglobin to oxyhemoglobin

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Черныш

Moroz

et al. 2016

International Journal of Pharmaceutics

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Blood plasma protein adsorption capacity of perfluorocarbon emulsion stabilized by proxanol 268 (in vitro and in vivo Studies)

Cited by 4 publications

References 6 publications

Effect of blood protein concentrations on drug-dosing regimes: practical guidance

Effect of blood protein concentrations on drug-dosing regimes: practical guidance

The effect of apolipoprotein A-I and perfluorocarbon emulsion on the production of specific antibodies in mice

Nanoparticles of perfluorocarbon emulsion contribute to the reduction of methemoglobin to oxyhemoglobin

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