Blood plasma cystatin c level and its relationship  with the augmentation index and central arterial  pressure in therapeutic patients

Муркамилов, И Т; Айтбаев, К А; Fomin, V V; Муркамилова, Ж. А.; Сабиров, И С; Bishkek, Kyrgyzstan; Moscow, Russia

doi:10.18565/nephrology.2018.3.31-40

Cited by 4 publications

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“…It is important to note that the PWV and the associated arterial augmentation index are interesting from the point of view of pathophysiology and have a great prognostic value. The role of SST as an independent risk factor for cardiovascular and renal diseases was summarized in our previous study [28,29]. We were able to demonstrate a significant increase in vascular augmentation index in persons with 3rd degree obesity, and persons with 1st degree obesity significantly increased the vascular stiffness index (Table 3).…”

Section: The Prevalence Of Nosological Types Of Socially Significant Diseases Obese People Examined N = 715supporting

confidence: 54%

The Stiffness of the Blood Vessels as a Component of Cardionephro - Cerebrovascular Risk for Obesity

Torobekovich

Fomin

2019

AJBSR

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Section: The Prevalence Of Nosological Types Of Socially Significant Diseases Obese People Examined N = 715supporting

confidence: 54%

The Stiffness of the Blood Vessels as a Component of Cardionephro - Cerebrovascular Risk for Obesity

Torobekovich

Fomin

2019

AJBSR

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Section: Discussionmentioning

confidence: 99%

“…Cystatin C is a protein consisting of 120 amino acid residues and belonging to the 2 nd group of the genetic family of cystatins [14].…”

Section: Discussionmentioning

confidence: 99%

“…As shown by early studies, cystatin C is contained in human blood plasma and excreted from the body by the kidneys [14]. It is established that the concentration of cystatin C is a more accurate marker of renal function than the creatinine level [14,15]. Currently, cystatin C, along with inulin, is considered the "gold standard" for determining GFR as an integral indicator of renal function, and its concentration in blood serum closely correlates with GFR [14,15].…”

Section: Discussionmentioning

confidence: 99%

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Cystatin C as the Predictor of Chronic Kidney Disease in Patients with Comorbid Pathology

Муркамилов

Fomin²,

Айтбаев³

et al. 2019

ASOAJ

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Purpose of the study:To study the content of cystatin C and to identify the factors reducing the glomerular filtration rate in patients with comorbid pathology.Materials and methods: 383 patients with comorbid pathology aged from 25 to 88 years (mean age 58.8±12.0 years) were examined, of whom 51.4% were men and 48.6% women. In the structure of comorbid pathology, arterial hypertension (AH) was observed in 76.5%, coronary heart disease (CHD) in 48.8%, diabetes mellitus (DM) type2 in 29.7%, obesity in 47, 5% and chronic obstructive pulmonary disease (COPD) in 28.9% of patients. The examined patients were divided into 4 groups: 1 st persons with hypertension+type2 diabetes (n = 99); 2 nd -AH + CHD (n = 138); 3 rd -AH + COPD (n = 102) and the 4 th group patients with severe comorbid pathology, i.e. AH + DM + CHD + COPD (n = 44). All patients were studied for lipid spectrum parameters [total cholesterol (cholesterol), high-density lipoprotein cholesterol (HDL cholesterol), low-density lipoprotein cholesterol (LDL cholesterol), triglycerides (TG)] and cystatin C of blood plasma. The glomerular filtration rate (GFR) was calculated according to the formula F.J. Hoek. The severity of renal dysfunction was assessed according to the recommendation of KDIGO (Kidney Disease: Improving Global Outcomes) 2012. The analysis of the prevalence of reduced GFR in patients with comorbid pathology was also carried out. Results:The presence of reduced GFR gradations of C2 and C3 "A" was detected in 46.7% and 24.8% of the examined individuals, respectively. Severe reduction in GFR was observed in 11.7% of patients. Sharply reduced GFR (C4 gradation) was significantly more frequently registered in women than in men (10.7% versus 5.0%; p <0.05). In the examined cohort, persons of middle and old age made up 36.8% and 42.2%, respectively. In patients with comorbid pathology, cases of hypercholesterolemia (41.7%), hypertriglyceridemia (45.4%) and elevated levels of LDL cholesterol (46.9%) were frequently detected, and in the 4 th group, the mean age and body mass index (BMI) were significantly higher, and cholesterol levels of HDL and GFR were significantly lower compared with other groups. In the 1st group (AH+DM type2), systolic blood pressure (SBP), total cholesterol and cystatin C plasma levels were significantly higher than in the AH+CHD, AH+COPD groups and patients with severe comorbid pathologies. Higher concentrations of LDL cholesterol were observed in patients with hypertension and COPD. In the 1 st group of patients, the GFR value closely correlated with age (r=-0.21; p=0.03), the level of SBP (r=-0.34; p=0.03), and concentration cystatin C of blood plasma (r=-0.87; p=0.01). In the 2 nd subgroup, the GFR index was associated with the level of the SBP (r=-0.32; p=0.03) and the concentration of cystatin C in the blood plasma (r=-0.86; p=0.03). In patients with AH, COPD negative association of GFR was recorded with age (r=-0.44; p=0.03), heart rate (r=-0.36; p=0.03), total cholesterol concentration (r=-0.20; p=0.04), HDL cholesterol ...

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“…According to our data, among patients with HTG, the average eGFR was significantly lower (Table 3). It was established that a slight decrease in GFR is reflected by changes in the concentration of cystatin C in the blood [28].…”

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confidence: 99%

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2018

JUNS

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Aim:The aim of the study was to study the clinical and functional features of renal dysfunction in conditions of hypertriglyceridemia and remodeling of the left ventricle.Materials and Methods: 176 patients with chronic kidney disease (CKD) were examined, 111 of them with hypertriglyceridemia (HTG) in association with left ventricular hypertrophy (LVH) 1st group and 65 patients with LVH in the absence of HTG, matched by gender and age. Along with general clinical studies, all patients were assessed for lipid spectrum parameters, measurement of cystatin C in blood plasma, and indicators of arterial stiffness (augmentation index and stiffness) and echocardiography were analyzed. Results:In the 2 nd group (HTG + LVH), the number of patients with type 2 diabetes mellitus (DM), a combination of hypertension, coronary heart disease and gout were significantly higher (p<0.05). Persons with chronic obstructive pulmonary disease, chronic pyelonephritis and cerebrovascular diseases were significantly more common in the 1st group (p <0.05). In the 2nd group, the value of BMI [(30.4 ± 5.2 kg/m 2 against 28.1±5.7 kg /m2; p = 0.013), the level of systolic blood pressure (BP) (140 ± 19 mm Hg). v. 134 ± 18 mmHg; p = 0.042), thickness of the posterior wall of the left ventricle (LV) (0.98 ± 0.18 cm versus 0.90 ± 0.16 cm; p = 0.008), relative thickness LV walls (0.385 ± 0.107 units versus 0.357 ± 0.060 units; p=0.032), the number of patients with concentric LV hypertrophy (29.2; versus 13.5%; p=0.008), total cholesterol content (5.80 (4.87;6.80) mmol/l vs. 4.75 (4.0;5.38) mmol / l; p=0.000); lowdensity lipoprotein cholesterol (3.56 (3.12;4.63 ) mmol/l versus 3.09 (2.61;3.79) mmol/l; p=0.045) cystatin C (1.25 (1.08;1.70) mg / l versus 1.16 (0.99;1.42) mg/l; p=0.026) turned out to be significantly higher, and the calculated glomerular filtration rate (eGFR) significantly lower (57.0 ± 22 ml / min versus 65.0±23 ml/min; p=0.028)] compared with the 1st group. A positive correlation was noted between the level of central BP (r=0.264; p=0.003), the augmentation index (r=0.224; p=0.011) and plasma cystatin C (r= 0.486; p=0.000) with the value of the indexed LV myocardium mass (LVMI) in the total sample surveyed. A negative correlation was recorded between the eGFR and LVMI (r=-0.425; p=0.000). Conclusion:In the presence of hypertriglyceridemia in patients with left ventricular hypertrophy, cystatin C increases in blood plasma and GFR decreases with a tendency for augmentation index to increase.

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Blood plasma cystatin c level and its relationship with the augmentation index and central arterial pressure in therapeutic patients

Cited by 4 publications

References 0 publications

The Stiffness of the Blood Vessels as a Component of Cardionephro - Cerebrovascular Risk for Obesity

The Stiffness of the Blood Vessels as a Component of Cardionephro - Cerebrovascular Risk for Obesity

Cystatin C as the Predictor of Chronic Kidney Disease in Patients with Comorbid Pathology

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