Blood plasma catecholamines and their urinary excretion in patients with acute myocardial infarction

Lukomsky, P.E.; Oganov, Raphael G.

doi:10.1016/0002-8703(72)90137-8

Cited by 40 publications

(6 citation statements)

References 15 publications

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“…Plasma catecholamine concentration is elevated and in the individual patient the level is fairly constant during the first 2 days after admission to hospital. The level may vary considerably in different patients and is dependent upon their degree of illness (1,2).…”

Section: Introductionmentioning

confidence: 99%

Plasma Catecholamines and Carbohydrate Metabolism in Patients with Acute Myocardial Infarction

Christensen¹,

Videbæk²

1974

J. Clin. Invest.

122

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A B S T R A C T Blood glucose, glucose tolerance, serum insulin, free fatty acids in serum, plasma noradrenaline, and plasma adrenaline were measured in 10 patients with acute myocardial infarction (AMI) as well as in healthy subjects. Both noradrenaline and adrenaline in plasma were elevated in patients with AMI, the level being fairly constant in the individual patients and dependent on their degree of illness.In the fasting state, blood glucose, serum insulin, and free fatty acids were elevated in patients with AMI. Plasma noradrenaline showed a highly significant correlation with the fasting blood glucose concentration, but not with serum insulin or free fatty acids. The concentration of free fatty acids in serum could be predicted only if both plasma noradrenaline and the basal insulin concentration were known.Intravenous glucose tolerance was Ireduced in patients with AMI, especially in patients with high plasma noradrenaline and a low initial rise in insulin. There was a significant negative correlation between the initial rise in insulin expressed in percentage of the basal insulin concentration and the plasma noradrenaline level.The statistical effects of serum insulin and plasma noradrenaline on the glucose tolerance could not be separated from each other. The decline in free fatty acids after intravenous injection of glucose showed a negative correlation with plasma noradrenaline and a positive correlation with the initial rise in insulin.Plasma adrenaline did not correlate with any of the metabolic parameters mentioned above.The plasma noradrenaline concentration was elevated to such a degree in patients with AMI that the observed changes in metabolism might have been caused directly by the circulating noradrenaline.During the glucose tolerance tests, the effect of noradrenaline was probably carried out indirectly via a suppression of insulin secretion. It is conceivable that

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Section: Introductionmentioning

confidence: 99%

Plasma Catecholamines and Carbohydrate Metabolism in Patients with Acute Myocardial Infarction

Christensen¹,

Videbæk²

1974

J. Clin. Invest.

122

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“…This was directly confirmed in five group I patients. We excluded group II patients from the catecholamine analysis since the presence of infarction would of itself be expected to result in excessive adrenergic stimulation.20 [28][29][30][31][32] The genesis of the adrenergic hyperactivity is not clear. This phenomenon has been previously reported in patients with angina pectoris.33-3 Previous studies have also shown that cardiopulmonary bypass results in marked sympathetic overactivity in the immediate postoperative period.20 40 Our study indicates this is still present two weeks after surgery but has disappeared by three months.…”

Section: Discussionmentioning

confidence: 99%

Left ventricular function and adrenergic hyperactivity before and after saphenous vein bypass.

Boudoulas¹,

Lewis²,

Vasko³

et al. 1976

Circulation

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Forty patients with severe angina pectoris were studied before and two weeks after saphenous vein bypass surgery (SVG) in order to assess the effect of this operation on left ventricular performance as judged by systolic time intervals (STI). The patients were divided into two groups: group I included 29 patients in whom no postoperative infarction occurred and group II was composed of 11 patients with postoperative infarction. For group I the PEP/LVET was 0.39 +/- 0.01 preop and slightly but significantly increased at 0.42 +/- 0.004 (P less than 0.025) two weeks postop. The mean preop PEP/LVET was 0.33 +/- 0.01 for group II and dramatically increased to 0.54 +/- 0.02 (P less than 0.001) after surgery. Another striking abnormally was a marked shortening of electromechanical systole (QS2I), which was uniformly present in the postoperative studies. Follow-up studies in 16 patients and urinary catecholamine determination in five patients suggested excessive adrenergic activity was responsible for the abbreviated QS2I. This phenomenon must be considered when interpreting the results of SVG on left ventricular function.

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“…Many studies have dealt with the metabolie events occurring after myocardial infarction. Thus, increased secretion and urinary excretion of catecholamines (Jequier and Pe"et 1970, Fluck 1972, Lukomsky and Oganov 1972, Vetter, Adams, Strange and Oliver 1974, increased levels of plasma cyclic adenosine monophosphate (cyclic AMP) (Strange, Vetter, Rowe and Oliver 1974), glucose and free fatty acids (Vetter et al 1974) as weil as decreased levels of insulin (Vetter et a1. 1974) have been reported.…”

Section: Introductionmentioning

confidence: 99%

Pituitary-Thyroid Axis Reaction after Myocardial Infarction

Vanhaelst¹,

Jp²,

Golstein³

et al. 1976

Horm Metab Res

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Within the first 36 hours following myocardial infarction, serum total thyroxine (T4) levels were supranormal in most cases in contrast to normal thyrotropin values. After one week, T4 levels dropped to normal while TSH values rose significantly. These findings suggest that, in the acute phase of myocardial infarction, the secretion of thyroid hormones is increased, thereby inhibiting the pituitary thyrotropes. The stimulation of thyroid secretion might be due to the high levels of blood catecholamines generally found in patients with myocardial infarction.

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Blood plasma catecholamines and their urinary excretion in patients with acute myocardial infarction

Cited by 40 publications

References 15 publications

Plasma Catecholamines and Carbohydrate Metabolism in Patients with Acute Myocardial Infarction

Plasma Catecholamines and Carbohydrate Metabolism in Patients with Acute Myocardial Infarction

Left ventricular function and adrenergic hyperactivity before and after saphenous vein bypass.

Pituitary-Thyroid Axis Reaction after Myocardial Infarction

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