1998
DOI: 10.3109/15368379809022572
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Blood Perfusion in a Murine Fibrosarcoma Tumor Model After Direct Current Electrotherapy a Study with86Rb Extraction Technique

Abstract: Electrotherapy with low-level direct current (DC) can induce antitumor effects in various tumor models. Applied in combination with certain anticancer drugs, it can significantly increase their effectiveness. It has been suggested that the demonstrated effects of electrotherapy arise from its modification of tumor blood flow. The effect of such treatment on blood perfusion of solid subcutaneous Sa-1 fibrosarcoma tumors in A/J mice was investigated with a &rubidium extraction technique. Following electrotherapy… Show more

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Cited by 5 publications
(4 citation statements)
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References 12 publications
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“…Relative perfusion of tumours remained decreased and did not change further for at least 24 h following the treatment as demonstrated by the present PBV data (figures 2(a) and (b)), which are in good agreement with the previously published results (Jarm et al 1997(Jarm et al , 1998(Jarm et al , 1999. In these earlier studies it was found that perfusion of tumours improved during the following days but was still significantly poorer than in control tumours 3 days after DC-ET in Sa-1 tumours and 2 days after DC-ET in LPB tumours.…”
Section: Discussionsupporting
confidence: 93%
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“…Relative perfusion of tumours remained decreased and did not change further for at least 24 h following the treatment as demonstrated by the present PBV data (figures 2(a) and (b)), which are in good agreement with the previously published results (Jarm et al 1997(Jarm et al , 1998(Jarm et al , 1999. In these earlier studies it was found that perfusion of tumours improved during the following days but was still significantly poorer than in control tumours 3 days after DC-ET in Sa-1 tumours and 2 days after DC-ET in LPB tumours.…”
Section: Discussionsupporting
confidence: 93%
“…In the study presented here the electrodes were placed in the healthy subcutaneous tissue surrounding tumours in mice. We have already shown in previous studies that such a treatment can reduce perfusion in solid tumours (Jarm et al 1997(Jarm et al , 1998(Jarm et al , 1999. In the present study we extended these studies by combining three different measurement methods to assess the effect of this type of DC-ET on blood flow, blood oxygenation and tissue oxygenation in two different experimental tumour models.…”
Section: Introductionmentioning
confidence: 70%
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“…This fact could be related with other experimental findings found after DEC treatment, such as: degradation of phospholipids, lost of high energy phosphate and increase of the intracellular calcium [7], membrane damage [5], ionic imbalance [2,12], mitochondrial alterations [9] and ischemia/reperfusion injury [13]. …”
Section: Discussionmentioning
confidence: 62%