Blood Oxidative Stress Biomarkers in Patients with Familial Mediterranean Fever (FMF)

Celi̇k, Serkan; Öktenli, Çağatay; Terekeci, Hakan; Ipcioglu, OM; Sanisoğlu, Yavuz; Sayan, Özkan; Yeşilova, Zeki; Yıldız, Özcan; Tunca, Yusuf; Nalbant, Selim

doi:10.1055/s-0029-1242797

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…This may suggest that disturbances in lipid and carbohydrate metabolisms may contribute to altered oxidative status in young obese males. Lastly, similar to previous reports , we observed that lipid hydroperoxide were correlated with hs‐CRP, which supports suggested role of subclinical inflammation on oxidative stress in obese subjects.…”

Section: Discussionsupporting

confidence: 92%

Increased acylation stimulating protein levels in young obese males is correlated with systemic markers of oxidative stress

Celi̇k

Tangi

Kılıçaslan

et al. 2013

Obesity

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Objective: As little is known about relationship between acylation stimulating protein (ASP) and oxidative stress, whether there is any link between ASP and oxidative stress in young obese males were investigated. . Results: Fasting plasma ASP, lipid hydroperoxide, high sensitivity C-reactive protein (hs-CRP), fasting insulin, triglyceride, LDL-cholesterol levels and HOMA-IR were higher, whereas the mean HDL-cholesterol levels and glutathione peroxidase (GPx) enzyme activity were significantly lower in obese subjects than controls. The linear regression analysis showed that lipid hydroperoxide was independently associated with only BMI, while ASP was independently associated with BMI and triglyceride. Conclusions: The present data support the concept that obesity occurs under condition of compex interactions by adipokines, insulin, inflammation, and oxidative stress.

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Section: Discussionsupporting

confidence: 92%

Increased acylation stimulating protein levels in young obese males is correlated with systemic markers of oxidative stress

Celi̇k

Tangi

Kılıçaslan

et al. 2013

Obesity

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“…Familial Mediterranean Fever (FMF) is the most common Mendelian autoinflammatory disorder, which is characterized by recurrent attacks of fever with peritoneal, pleural or synovial inflammation ( 1 – 4 ). Missense mutations in the Mediterranean fever ( MEFV) gene have been shown to be causative of the disease ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Increased frequency of Mediterranean fever gene variants in multiple myeloma

2014

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High frequencies of inherited variants in the Mediterranean fever (MEFV) gene have been identified in patients with multiple myeloma (MM). The sample size of the present pilot study was small, therefore, the actual frequency of inherited variants in the MEFV gene could be investigated in patients with MM. Twenty-eight patients with MM and 65 healthy controls were included in the study. Six heterozygous and one homozygous (E148Q/E148Q) variant was identified in patients with MM. None of the patients had a family history compatible with familial Mediterranean fever. In the healthy control group, 11 heterozygous variants were identified. The difference in the overall frequency of the inherited variants in the MEFV gene between the MM patients and the controls was statistically significant (χ2=4.905; P=0.027). In conclusion, a high frequency of inherited variants in the MEFV gene was identified in patients with MM. Based on the current data, it is hypothesized that the MEFV gene is a cancer susceptibility gene. Additional evidence, such as familial aggregation, monozygotic versus dizygotic twin concordance, and tumors in genetically engineered model organisms, is required in order to support this hypothesis.

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Blood Oxidative Stress Biomarkers in Patients with Familial Mediterranean Fever (FMF)

Cited by 2 publications

References 13 publications

Increased acylation stimulating protein levels in young obese males is correlated with systemic markers of oxidative stress

Increased acylation stimulating protein levels in young obese males is correlated with systemic markers of oxidative stress

Increased frequency of Mediterranean fever gene variants in multiple myeloma

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