Blood neutrophil-to-lymphocyte ratio independently predicts survival in patients with liver cirrhosis

Bıyık, Murat; Uçar, Ramazan; Solak, Yalçın; Güngör, Gökhan; Polat, İlker; Gaipov, Abduzhappar; Çakır, Özlem Özer; Ataseven, Hüseyin; Demir, Ali; Türk, Süleyman; Polat, Hakkı

doi:10.1097/meg.0b013e32835c2af3

Cited by 132 publications

(129 citation statements)

References 25 publications

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“…More importantly, the NLR could predict mortality in patients with low MELD and/or CTP scores. 41 Furthermore, neutrophil gelatinase-associated lipocalin was found to be a predictor of mortality in cirrhosis patients with hepatorenal syndrome. 42 Anti-neutrophil cytoplasmic antibodies are a non-uniform family of antibodies that recognizes diverse neutrophil components.…”

Section: Neutrophils and Liver Fibrosis/cirrhosismentioning

confidence: 99%

The role of neutrophils in the development of liver diseases

et al. 2014

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Liver disease encompasses a wide variety of liver conditions, including liver failure, liver cirrhosis and a spectrum of acute and chronic hepatitis, such as alcoholic, fatty, drug, viral and chronic hepatitis. Liver injury is a primary causative factor in liver disease; generally, these factors include direct liver damage and immune-mediated liver injury. Neutrophils (also known as neutrophilic granulocytes or polymorphonuclear leukocytes (PMNs)) are the most abundant circulating white blood cell type in humans, and PMNs are a major innate immune cell subset. Inappropriate activation and homing of neutrophils to the microvasculature contributes to the pathological manifestations of many types of liver disease. This review summarizes novel concepts of neutrophil-mediated liver injury that are based on current clinical and animal model studies.

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Section: Neutrophils and Liver Fibrosis/cirrhosismentioning

confidence: 99%

The role of neutrophils in the development of liver diseases

et al. 2014

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“…In the literature, the NLR has also been found to be associated with various liver diseases (14,15). In the results of this study, it was observed that the NLR was higher in NASH patients than in the healthy controls and simple liver steatosis patients.…”

Section: Discussionmentioning

confidence: 99%

The Neutrophil-to-Lymphocyte Ratio as A Noninvasive Marker in Patients with Biopsy-Proven Non-Alcoholic Steatohepatitis

Asıl¹,

Dertli²

2016

Istanbul Med J

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“…Neutrophillymphocyte ratio (NLR) is a marker that can be estimated by using leukocyte subtypes from the complete blood count. Moreover, it has been reported that NLR may have prognostic value in some diseases [7,8].In the current literature, there is no study evaluating MPV and NLR together in gout. In this retrospective study, we investigated the role of MPV and NLR in the determining disease activity in gout disease.…”

mentioning

confidence: 99%

“…MPV is indirectly linked to platelet activity. Larger platelets are more active than smaller ones in terms of metabolic and enzymatic activity [4][5][6][7][8][9]. Neutrophillymphocyte ratio (NLR) is a marker that can be estimated by using leukocyte subtypes from the complete blood count.…”

mentioning

confidence: 99%

Neutrophil: Lymphocyte Ratio and Mean Platelet Volume in Patients with Gout

Balkarlı¹

2017

Ann Clin Anal Med

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ÖzetAmaç: Gut artmış ürik asit konsantrasyonu ile birlikte monosodyum ürat (MSU) kristallerine karşı oluşan inflamatuar yanıtın yol açtığı klinik bir sendromdur. Gut hastalığında inflamatuar yanıtın oluşmasında nötrofiller önem-lidir ve nötrofil aktivasyonu lokal olarak üretilen sitokinlere bağlıdır. Ortalama trombosit hacmi (MPV) ve nötrofil lenfosit oranı (NLR) bazı hastalıklarda inflamatuar belirteç olarak değerlendirilmiş ve prognostik öneme sahip olabileceği bildirilmiştir. Bildiğimiz kadarıyla literatürde gut hastalığında MPV ve/ veya N/L oranının değerlendirildiği bir çalışma yoktur. Biz bu retrospektif ça-lışmamızda gut hastalığında inflamasyonun belirlenmesinde MPV ve NLR' nin rolünü araştırdık. Gereç ve Yöntem: Retrospektif olarak dizayn edilmiş olan bu çalışmaya gut hastalarının dosyaları taranarak çalışmaya dahil edilme kriterlerini karşılayan toplam 106 ( 91 erkek, 15 kadın) gut hastası ve yaş-cinsiyet eşleştirmeli 148 ( 128 erkek, 20 kadın) sağlıklı kontrol grubu alındı. Hasta grubunun atak dönemi (Grup I) ve ataksız dönemi (grup II) laboratuvar verileri toplandı. Bulgular: Gut hasta grubu yaş ortalaması 59.46±12.93 yıl, sağlık-lı kontrol grubu yaş ortalaması 59±11.33 yıl idi. Her iki grup yaş ve cinsiyet açısından benzerdi. İlk atak yaşı 52±12.77 yıl, ilk iki atak arası süre 6±5.52 ay idi. Hastaların 9'unda (%8.5) tofüs, 17'sinde (%16) gut aile öyküsü vardı. MPV her üç grupta da benzerdi. CRP ve eritrosit sedimentasyon hızı, atak dönem gut hasta grubunda ataksız dönem gut hasta grubuna göre istatistiksel anlamlı yüksek saptandı. N/L oranı her üç grupta da istatistiksel olarak anlamlı farklılık gösteriyordu. Tofüs varlığına göre hastalar sınıflandırıldığında ise her iki grupta da MPV ve N/L oranının benzer olduğu görüldü. Tartışma: N/L oranı hem atak hem ataksız dönem gut hastalarında sağlıklı kontrol grubuna göre artmıştı. Bu çalışma gut hastalarının kronik inflamasyona maruz kaldı-ğını göstermektedir. Bu nedenle N / L oranı gut hastalığında inflamasyonun gösterilmesinde basit, ucuz ve kullanışlı tanısal belirteç olabilir. Anahtar KelimelerGut; Nötrofillenfositoranı; Ortalama Trombosit Hacmi Abstract Aim: Gout is a clinical syndrome with increased uric acid concentration, which is caused by inflammatory response against monosodium urate (MSU) crystals. In gout, neutrophils are involved in inflammatory response and neutrophil activation is dependent on local cytokine production. Mean platelet volume (MPV) and neutrophillymphocyte ratio (NLR) are considered as inflammatory markers in several diseases and it is reported that they may have prognostic significance. Inthe current literature, there is no study evaluating MPV and NLR in gout. In this retrospective study, we investigated the role of MPV and NLR in determining inflammation in gout disease. Material and Method: In this retrospective study, 106 patients with gout (91 men and 15 women) meeting the inclusion criteria based on patient records and 148 ageand sex-matched healthy controls (128 men and 20 women) were included. Laboratory data during...

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Blood neutrophil-to-lymphocyte ratio independently predicts survival in patients with liver cirrhosis

Abstract: NLR is a predictor of mortality independent of CTP and MELD scores in patients with liver cirrhosis. NLR could predict mortality in the subgroup of patients with low MELD scores as well.

Cited by 132 publications

References 25 publications

The role of neutrophils in the development of liver diseases

The role of neutrophils in the development of liver diseases

The Neutrophil-to-Lymphocyte Ratio as A Noninvasive Marker in Patients with Biopsy-Proven Non-Alcoholic Steatohepatitis

Neutrophil: Lymphocyte Ratio and Mean Platelet Volume in Patients with Gout

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