Blood neutrophil-lymphocyte ratio predicts survival after hepatectomy for hepatocellular carcinoma: A propensity score-based analysis

Yang, Haojie; Guo, Zhe; Yang, Yuting; Jiang, Jing‐Hang; Qi, Yinliang; Li, Ji-Jia; Li, Le‐Qun; Xiang, Bang‐De

doi:10.3748/wjg.v22.i21.5088

Cited by 40 publications

(43 citation statements)

References 26 publications

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“…Higher NLR level was associated with poor disease-free survival and overall survival [25–27]. Our study found that NLR > 3.27 may be an indicator of poor overall survival in patients with HCC and T2DM.…”

Section: Discussionmentioning

confidence: 54%

HbA1c-Based Score Model for Predicting Death Risk in Patients with Hepatocellular Carcinoma and Type 2 Diabetes Mellitus

Shuan

Liu

et al. 2017

Journal of Diabetes Research

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Aim. To establish a new score model to predict risk of death in patients with hepatocellular carcinoma and type 2 diabetes mellitus. Methods. This was a retrospective study of 147 patients with hepatocellular carcinoma and type 2 diabetes mellitus who came to Beijing Ditan Hospital between October 2008 and June 2013. Univariate and multivariate logistic regression analysis was performed to obtain the independent factors associated with death risk. A new score model was devised according to these factors. Results. A prediction score model composed of HbA1c, NLR, age, and CTP class was devised, which ranged from 0 to 7. AUROC of the score was 0.853 (P < 0.001, 95% CI: 0.791–0.915). Scores 0–2, 3-4, and 5–7 identified patients as low-, medium-, and high-risk categories. The cumulative survival rate was 93.6%, 83.0%, and 74.5% in the low-risk group in 1, 2, and 3 years, while it was 64.0%, 46.0%, and 26.0% in the medium-risk group, whereas it was 24.0%, 12.0%, and 6.0% in the high-risk group, respectively. The cumulative survival rate was significantly higher in the low-risk group than that in the medium-risk group and high-risk group (P < 0.001). Conclusion. The HbA1c-based score model can be used to predict death risk in patients with hepatocellular carcinoma and type 2 diabetes mellitus.

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Section: Discussionmentioning

confidence: 54%

HbA1c-Based Score Model for Predicting Death Risk in Patients with Hepatocellular Carcinoma and Type 2 Diabetes Mellitus

Shuan

Liu

et al. 2017

Journal of Diabetes Research

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“…Sensitivity analysis showed that the combined HR of OS had high stability by omitting any single study, for that the pooled HRs ranged from 1.51 (95% CI 1.37, 1.66) after omitting the study of Aino et al to 1.53 (95% CI 1.39, 1.69) after omitting the study of Yang et al . High stability was also found in subgroups of LR, LT, HAIC, and RFA.…”

Section: Resultsmentioning

confidence: 98%

“…However, the mechanism or precise correlation between inflammation response and malignancies has not been clarified. Previous studies have indicated that the pretreatment NLR was an important prognostic factor in patients with HCC after each treatment . The molecular mechanism of the prognostic role of NLR may involve many factors.…”

Section: Discussionmentioning

confidence: 99%

“…Inflammation markers, such as neutrophil‐lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), modified Glasgow prognostic score (mGPS), and prognostic nutritional index (PNI), have been evaluated for their prognostic value in patients with malignant tumors. Many researches have shown that elevated NLR could predict poor survival in patients with HCC after liver resection (LR), radiofrequency ablation (RFA), transarterial chemoembolization (TACE), and liver transplantation (LT) . However, fallaciously, their results still remained inconsistent, with several studies drawing inverse conclusions.…”

Section: Introductionmentioning

confidence: 99%

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The pretreatment neutrophil‐lymphocyte ratio may predict prognosis of patients with liver cancer: A systematic review and meta‐analysis

Гао

Yao

et al. 2017

Clinical Transplantation

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“…[1][2][3] Hepatectomy is considered one of the most effective curative treatments for many patients with HCC, yet long-term survival remains less than satisfactory because of the high frequency of postoperative tumor recurrence. 4 Predicting which patients are more likely to experience recurrence after hepatectomy may help guide their postoperative management.…”

Section: Introductionmentioning

confidence: 99%

Stratified aspartate aminotransferase-to-platelet ratio index accurately predicts survival in hepatocellular carcinoma patients undergoing curative liver resection

et al. 2017

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The aspartate aminotransferase-to-platelet ratio index has been reported to predict prognosis of patients with hepatocellular carcinoma. This study examined the prognostic potential of stratified aspartate aminotransferaseto-platelet ratio index for hepatocellular carcinoma patients undergoing curative liver resection. A total of 661 hepatocellular carcinoma patients were retrieved and the associations between aspartate aminotransferase-toplatelet ratio index and clinicopathological variables and survivals (overall survival and disease-free survival) were analyzed. Higher aspartate aminotransferase-to-platelet ratio index quartiles were significantly associated with poorer overall survival (p = 0.002) and disease-free survival (p = 0.001). Multivariate analysis showed aspartate aminotransferase-to-platelet ratio index to be an independent risk factor for overall survival (p = 0.018) and diseasefree survival (p = 0.01).Patients in the highest aspartate aminotransferase-to-platelet ratio index quartile were at 44% greater risk of death than patients in the first quartile (hazard ratio = 1.445, 95% confidence interval = 1.081 -1.931, p = 0.013), as well as 49% greater risk of recurrence (hazard ratio = 1.49, 95% confidence interval = 1.112-1.998, p = 0.008). Subgroup analysis also showed aspartate aminotransferase-to-platelet ratio index to be an independent predictor of poor overall survival and disease-free survival in patients positive for hepatitis B surface antigen or with cirrhosis (both p < 0.05). Similar results were obtained when aspartate aminotransferase-to-platelet ratio index was analyzed as a dichotomous variable with cutoff values of 0.25 and 0.62. Elevated preoperative aspartate aminotransferase-to-platelet ratio index may be independently associated with poor overall survival and disease-free survival in hepatocellular carcinoma patients following curative resection.

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Blood neutrophil-lymphocyte ratio predicts survival after hepatectomy for hepatocellular carcinoma: A propensity score-based analysis

Abstract: Preoperative NLR ≥ 2.81 may be an indicator of poor DFS and OS in patients with HCC undergoing surgery. Preoperative NLR ≥ 2.81 may be a good complementary indicator of poor OS when elevated AFP levels provide no prognostic information.

Cited by 40 publications

References 26 publications

HbA1c-Based Score Model for Predicting Death Risk in Patients with Hepatocellular Carcinoma and Type 2 Diabetes Mellitus

HbA1c-Based Score Model for Predicting Death Risk in Patients with Hepatocellular Carcinoma and Type 2 Diabetes Mellitus

The pretreatment neutrophil‐lymphocyte ratio may predict prognosis of patients with liver cancer: A systematic review and meta‐analysis

Stratified aspartate aminotransferase-to-platelet ratio index accurately predicts survival in hepatocellular carcinoma patients undergoing curative liver resection

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