Blood mercury, lead and cadmium levels and determinants of exposure among newcomer South and East Asian women of reproductive age living in Vancouver, Canada

Dix-Cooper, Linda; Kosatsky, Tom

doi:10.1016/j.scitotenv.2017.11.126

Cited by 39 publications

(32 citation statements)

References 40 publications

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“…A rather unexpected finding was the complete lack of association between dietary habits and erythrocyte lead concentrations. While diet is commonly not seen as a primary source of lead in the general population, previous reports suggested that some foods or food groups may play a role, for instance fish and shellfish [26] or dairy products [27]. Instead, none of these associations was confirmed in adjusted analyses in our study, neither in the total study sample, nor in any of the subgroup analyses (including never smokers).…”

Section: Discussioncontrasting

confidence: 92%

Determinants of Erythrocyte Lead Levels in 454 Adults in Florence, Italy

Caini¹,

Bendinelli²,

Masala³

et al. 2019

IJERPH

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Background: Lead exposure, even at low levels, is associated with adverse health effects in humans. We investigated the determinants of individual lead levels in a general population-based sample of adults from Florence, Italy. Methods: Erythrocyte lead levels were measured (using inductively coupled plasma-mass spectrometry) in 454 subjects enrolled in the Florence cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC) study in 1992–1998. Multiple linear regression models were used to study the association between demographics, education and working history, lifestyle, dietary habits, anthropometry, residential history, and (among women) menstrual and reproductive history and use of exogenous sex hormones, and erythrocyte lead levels. Results: Median lead levels were 86.1 μg/L (inter-quartile range 65.5–111.9 μg/L). Male gender, older age, cigarette smoking and number of pack-years, alcohol intake, and residing in urban areas were positively associated with higher erythrocyte lead levels, while performing professional/managerial or administrative work or being retired was inversely associated with lead levels. Among women, lead levels were higher for those already in menopause, and lower among those who ever used hormone replacement therapy. Conclusions: Avoidable risk factors contribute to the lead body burden among adults, which could therefore be lowered through targeted public health measures.

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Section: Discussioncontrasting

confidence: 92%

Determinants of Erythrocyte Lead Levels in 454 Adults in Florence, Italy

Caini¹,

Bendinelli²,

Masala³

et al. 2019

IJERPH

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“…Calcium, of which milk and other dairy products are a major dietary source, is a low affinity inhibitor of DMT1 activity [62] and so a diet that is high in calcium might be expected to lower B-Cd. We found no association of B-Cd with the frequency of drinking milk or with calcium intake, although a previous study of East and South Asian women of reproductive age who had recently immigrated to Canada (≤5 years) found that higher dairy product consumption was associated with a 14% lower risk of elevated B-Cd [63]. In addition, increasing dietary calcium and vitamin D in pregnant women also in Canada was associated with lower B-Cd [64].…”

Section: Discussioncontrasting

confidence: 88%

“…In addition, increasing dietary calcium and vitamin D in pregnant women also in Canada was associated with lower B-Cd [64]. The disparity between our study and these two studies could be accounted for by differences in the mean frequency of milk/dairy consumption, but comparison is difficult because of differences in the way in which variables are expressed [63] included data on the consumption of dairy items (52 ± 34 times/month); the present UK study included data specifically for milk (44% never or rarely consumed milk, 48% had 7-14 glasses per week, and 9% had ≥21 glasses per week). The disparity in the results could also indicate differences in the frequency of consumption of other foods and food groups, which could have a secondary effect on both dietary intake and absorption of Cd.…”

Section: Discussioncontrasting

confidence: 72%

Maternal Diet During Pregnancy and Blood Cadmium Concentrations in an Observational Cohort of British Women

et al. 2020

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Few studies have investigated the extent to which diet predicts body Cd concentrations among women of reproductive age, and pregnant women in particular. The aim of this study was to examine diet as a predictor of blood Cd concentrations in pregnant women participating in the UK Avon Longitudinal Study of Parents and Children (ALSPAC). Whole blood samples were analysed for Cd (median 0.26 (IQR 0.14–0.54) µg/L). Dietary pattern scores were derived from principal components analysis of data from a food frequency questionnaire. Associations between dietary pattern scores and foods/food groups with blood Cd ≥ median value were identified using adjusted logistic regression (n = 2169 complete cases). A health conscious dietary pattern was associated with a reduced likelihood of B-Cd ≥0.26 µg/l (OR 0.56 (95% CI 0.39–0.81)). There were similarly reduced likelihoods for all leafy green and green vegetables (0.72 (0.56–0.92) when consumed ≥4 times/week vs ≤1 to ≥3 times/week) and with all meats (0.66 (0.46–0.95) when consumed ≥4 times/week vs ≤ once in 2 weeks). Sensitivity analysis excluding smokers showed similar results. The evidence from this study provides continued support for a healthy and varied diet in pregnancy, incorporating foods from all food groups in accordance with national recommendations, without the need for specific guidance.

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“…52 Its level increased in accordance with the number of dental amalgam fillings in the children, as well as the consumption of marine and fish products. 53 On average, the levels of Hg in the body of the screened persons did not exceed the recommended values.…”

Section: Mercury Levels In Blood and Urinementioning

confidence: 89%

Mercury exposure and its effects on fertility and pregnancy outcome

Bjørklund

Chirumbolo

Dadar

et al. 2019

Basic Clin Pharma Tox

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Mercury (Hg), a highly toxic environmental pollutant, shows harmfulness which still represents a big concern for human health, including hazards to fertility and pregnancy outcome. Research has shown that Hg could induce impairments in the reproductive function, cellular deformation of the Leydig cells and the seminiferous tubules, and testicular degeneration as well as abnormal menstrual cycles. Some studies investigated spontaneous abortion and complicated fertility outcome due to occupational Hg exposure. Moreover, there is a relation between inhaled Hg vapour and reproductive outcome. This MiniReview evaluates the hypothesis that exposure to Hg may increase the risk of reduced fertility, spontaneous abortion and congenital deficits or abnormalities.

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Blood mercury, lead and cadmium levels and determinants of exposure among newcomer South and East Asian women of reproductive age living in Vancouver, Canada

Cited by 39 publications

References 40 publications

Determinants of Erythrocyte Lead Levels in 454 Adults in Florence, Italy

Determinants of Erythrocyte Lead Levels in 454 Adults in Florence, Italy

Maternal Diet During Pregnancy and Blood Cadmium Concentrations in an Observational Cohort of British Women

Mercury exposure and its effects on fertility and pregnancy outcome

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