Blood markers of inflammation and coagulation and exposure to airborne particles in employees in the Stockholm underground

Bigert, Carolina; Alderling, Magnus; Svartengren, Magnus; Plato, Nils; Fairé, Ulf dé; Gustavsson, Per

doi:10.1136/oem.2007.038273

Cited by 52 publications

(50 citation statements)

References 28 publications

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“…It showed that the inflammatory response, measured as plasma concentrations of PAI-1, IL-6 and fibrinogen, had a tendency to be higher for subway platform workers than for nonsmoking healthy train drivers and subway ticket sellers [16]. In our present study, the plasma levels of fibrinogen also increased after subway exposure.…”

Section: Discussionsupporting

confidence: 66%

“…Another study showed that the inflammatory response, measured as blood plasma concentrations of plasminogen activator inhibitor (PAI)-1, interleukin (IL)-6 and fibrinogen, had a tendency to be higher for subway platform workers than for train drivers and subway ticket sellers. Measurements were performed on nonsmoking healthy workers after two non-working days and after two working days [16].…”

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confidence: 99%

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Health effects of a subway environment in healthy volunteers

Nyström

Svartengren²,

Grünewald³

et al. 2009

European Respiratory Journal

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Environmental particle exposure, often estimated as the particulate mass of particles with a diameter ,10 mm, ,2.5 mm or ,1 mm (PM10, PM2.5 or PM1), is known to have a negative impact on the health of the population. Little is known about how the size and origin of particles influence the effects. We have previously shown that exposure to a road tunnel environment causes a cellular inflammatory response in the airways of healthy individuals. In the present study, our aim was to investigate potential airway health effects from exposure to a subway environment.20 healthy volunteers were exposed to a subway and a control environment for 2 h, followed by measurements of lung function and the inflammatory response in the lower airways (bronchoscopy) and in the peripheral blood.No cellular response was found in the airways after exposure to the subway environment. In the blood, we found a statistically significant increase in fibrinogen and regulatory T-cells expressing CD4/CD25/FOXP3.Subway and road tunnel environments have similar levels of PM10 and PM2.5, whilst the concentrations of ultrafine particles, nitrogen monoxide and dioxide are lower in the subway. Although no cellular response was detected, the findings indicate a biological response to the subway environment. Our studies show that using gravimetric estimates of ambient particulate air pollution alone may have clear limitations in health-risk assessment.

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Section: Discussionsupporting

confidence: 66%

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confidence: 99%

Health effects of a subway environment in healthy volunteers

Nyström

Svartengren²,

Grünewald³

et al. 2009

European Respiratory Journal

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“…In our study, the highest exposed group platform workers had similar exposure levels (mean levels of PM 2.5 and PM 0.1-10 were 63 µg/m 3 and 182 µg/m 3 , respectively) as in the two aforementioned studies, but the exposure time was longer, 8 as opposed to 2 hours. In a previous investigation among the same study group of employees in the Stockholm subway, we found elevated plasma concentrations of the inflammatory marker PAI-1 and a tendency to elevated plasma concentrations of hs-CRP among platform workers, relative to employees with low exposure, but the differences observed could not definitely be linked to particle exposure as such, and we found no short-term effects of particle exposure on blood markers of inflammation and coagulation (24). These results are in accordance with the absence of short-term effects on airway inflammation in the present study.…”

Section: Bigert Et Almentioning

confidence: 85%

“…All participants had previously fasted overnight due to the need for the collection of blood samples as part of the medical examination. The results from analyses of blood samples have been presented elsewhere (24). The examination included the recording of weight and height.…”

Section: Background Characteristicsmentioning

confidence: 99%

No short-term respiratory effects among particle-exposed employees in the Stockholm subway

Bigert

Alderling²,

Svartengren³

et al. 2010

Scand J Work Environ Health

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“…Pulmonary inflammation and cardiovascular disease risk increased after air pollution control during the Olympic period (Huang et al, 2012a;Huang et al, 2012b). Moreover, enrichment of heavy metals, like Fe and others, in fine particles could also induce potential health consequences (Bachoual et al, 2007;Bigert et al, 2008;Karlsson et al, 2008;Karlsson et al, 2005;Morman and Plumlee, 2014). Considering the presence of PM sustained and accelerated by the strong air convection in the Beijing subway environment, there is immense scope for the collaboration between environmental and toxicological specialists.…”

Section: Implications For Subway Air Quality Managementmentioning

confidence: 99%

Granulometric and magnetic properties of deposited particles in the Beijing subway and the implications for air quality management

Cui

Zhou

Dearing

2016

Science of The Total Environment

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The subway system is an important traffic facility in Beijing and its internal air quality is an environmental issue that could potentially affect millions of people every day. Due to the intrinsic nature of rail abrasion in subway tunnels, iron-containing particles can be generated and become suspended in the subway environment. While some studies (e.g. Li et al., 2006) have monitored the in-train levels of PM2.5s (particles < 2.5 μm), there is a lack of systematic assessment of the concentration and characteristics of iron-containing particles in the Beijing subway system. Here we report results of a study on the granulometric and magnetic properties of particulate samples collected at different localities of the Beijing subway system. Our results show that the subway samples are characterized by the presence of very fine particles. Volume proportions of 6.1 ± 1.3 % for PM2.5s and 27.5 ± 6.1 % for PM10s (particles < 10 μm) are found in the bulk subway particulate samples. These samples exhibit a strong magnetic signal, which is approximately two orders of magnitude higher than that in naturally deposited particles collected in Beijing. Fine grained ferromagnetic and ferrimagnetic minerals (e.g. iron and magnetite, respectively) are identified from mineral magnetic measurements and scanning electric microscopy. The samples collected from the Beijing stations with platform screen doors are found to be magnetically stronger and finer than those without them, suggesting that platform screen doors have failed to block the fine iron-containing particulate matters released from the rail tunnel. Given the potential health consequences of fine suspended ironcontaining particles, our results have important implications for air quality management in the Beijing subway system. We here submit a manuscript entitled "Granulometric and magnetic properties of particulate matter in the Beijing subway and the implications for air quality management". This work reports our finding of very fine particle matters in the Beijing subway environment, which are characterized by distinctly strong magnetic signals compared to those in naturally deposited particles. We also found variation of magnetic PM in the subway environment with platform screen door designs.Considering the potential health consequences of fine suspended iron-containing particles identified with magnetic techniques, our results not only have important implications for air quality management in the Beijing subway system but also demonstrate a new way of assessing environmental quality in metropolitan cities with subways.Thank you for your consideration. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 2 ABSTRACT The subway system is an important traffic facility in Beijing and its internal air quality is an environmental issue that could potentially affect mill...

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Blood markers of inflammation and coagulation and exposure to airborne particles in employees in the Stockholm underground

Abstract: Employees who were highly exposed to airborne particles in the Stockholm underground tended to have elevated levels of risk markers for CVD relative to employees with low exposure. However, the differences observed cannot definitely be linked to particle exposure as such.

Cited by 52 publications

References 28 publications

Health effects of a subway environment in healthy volunteers

Health effects of a subway environment in healthy volunteers

No short-term respiratory effects among particle-exposed employees in the Stockholm subway

Granulometric and magnetic properties of deposited particles in the Beijing subway and the implications for air quality management

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