Blood Manganese Concentration is Elevated in Iron Deficiency Anemia Patients, Whereas Globus Pallidus Signal Intensity is Minimally Affected

Kim, Yangho; Park, Ji Kang; Choi, Yu-Sung; Yoo, Cheol-In; Lee, Choong Ryeol; Lee, Hun; Lee, Ji-Ho; Kim, Sung-Ryul; Jeong, Tae Heum; Yoon, Chung Sik; Park, Jae-Hoo

doi:10.1016/j.neuro.2004.06.004

Cited by 74 publications

(42 citation statements)

References 24 publications

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“…123 Finally, blood levels of Mn in Fedeficient anemic patients were higher than in those who were non-anemic, averaging 2.05 vs. 1.28 mg dl À1 , respectively. 124 This result is similar to that of a study by Smith et al which reported median blood Mn concentrations to be higher in Fe deficient anemic children when compared to controls (1.64 vs. 1.1 mg dl À1 ). 125 A mouse model of hemochromatosis, a condition whereby loss of the HFE gene leads to unregulated intestinal Fe absorption, was used to demonstrate decreased Mn absorption due to Fe overload.…”

Section: Ironsupporting

confidence: 91%

Nutritional Requirements for Manganese

Freeland‐Graves¹,

Mousa²,

Sanjeevi³

2014

Manganese in Health and Disease

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Manganese (Mn) is a ubiquitous trace mineral that is essential for living organisms. This mineral is a cofactor of enzymes such as superoxide dismutase and arginase. It assumes a significant role in the metabolism of carbohydrates, amino acids and cholesterol, the formation of bone, digestion, and development. Food sources include whole grains, cereals, green leafy vegetables, nuts, and tea. Approaches to assess Mn requirements include metabolic balance, blood levels, and response of biomarkers. In the United States, the adequate intake (AI) of Mn is 1.8 and 2.3 mg day−1 for women and men, respectively. Negative balance has been reported in numerous studies, where Mn intake was greater than the AI; thus, the adequacy of current dietary recommendations is unclear. Factors that influence Mn requirements include life stage and gender, bioavailability (fiber, phytates, mineral interactions, polyphenolic compounds), and international considerations. Deficiency of Mn has been associated with adverse health conditions including dermatitis, osteoporosis, dyslipidemia, diabetes, metabolic syndrome, hypertension, epilepsy, cancer, asthma, problems with cognitive function, and poor birth outcomes. Toxicity of Mn may be a potential problem with contaminated drinking water, parenteral nutrition, individuals with hepatic dysfunction, and soy formula-fed infants. An understanding of Mn nutrient requirements is important for achievement of optimal health.

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Section: Ironsupporting

confidence: 91%

Nutritional Requirements for Manganese

Freeland‐Graves¹,

Mousa²,

Sanjeevi³

2014

Manganese in Health and Disease

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“…In addition, the absorbed excess manganese is promptly excreted into the bile from the liver and rarely causes manganese toxicity [22,32]. Iron deficiency anemia promotes manganese absorption in the intestine and elevation of the manganese concentration in the blood, but the signal intensity of the globus pallidus on T1WI is not affected [33]. In this way, manganese neurotoxicity is caused by mine dust inhalation or intravenous administration but rarely by oral intake [34,35].…”

Section: Manganesementioning

confidence: 99%

Contribution of metals to brain MR signal intensity: review articles

et al. 2016

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“…Major dietary sources of manganese include grains, nuts, tea, fruits, legumes and other vegetables [111,112]. Since the proportion of manganese absorbed from the intestine and retained in tissue varies inversely with iron stores [31, 65,90], iron deficiency anemia may contribute to the progression of AHD and should be corrected when present. If symptoms of AHD result from false neurotransmitters derived from aromatic amino acids, supplementing branched-chain amino acids may be useful, as they compete with aromatic amino acids to cross the bloodbrain barrier [63].…”

Section: Treatmentmentioning

confidence: 99%

Acquired hepatocerebral degeneration

2009

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Cirrhosis and its co-morbidities may cause a variety of neurological complications, the most common being bouts of toxic metabolic encephalopathy. A proportion of patients with chronic liver disease develop acquired hepatocerebral degeneration (AHD), a chronic progressive neurological syndrome characterized by parkinsonism, ataxia and other movement disorders. This article reviews the clinical spectrum, pathophysiology, neuroimaging features and differential diagnosis of AHD along with emerging treatment options.

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Blood Manganese Concentration is Elevated in Iron Deficiency Anemia Patients, Whereas Globus Pallidus Signal Intensity is Minimally Affected

Cited by 74 publications

References 24 publications

Nutritional Requirements for Manganese

Nutritional Requirements for Manganese

Contribution of metals to brain MR signal intensity: review articles

Acquired hepatocerebral degeneration

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