Blood Lymphocytes after Radiation Therapy of Mammary Carcinoma

Role of B Cells in the Expression of the PPD Response of Human Lymphocytes In Vitro

“…Recently, it was found that local radiotherapy of women with carcinoma of the breast or patients with carcinoma of the urinary bladder or prostate causes a significant reduction of the lymphocytes' response to PPD (5,8). The radiotherapy was observed to deplete the peripheral blood lympliocyte population by approximately 509^ (4,5,8). The percentage of lymphocytes that nonspecifitally adhere sheep erythrocytes in vitro (mainly T cells) increased after irradiation, whereas lymphocytes with membrane-associated receptors for activated C} were decreased (mainly B cells) {4, 5).…”

Long term effects of radiation of T and B lymphocytes in peripheral blood of patients with Hodgkin's disease.

“…However, at the completion of treatment, the mean total lymphocyte count of 503/mm3 was 4 SD below the mean for normal controls. Acute lymphocytopenia after a course of radiation has been described in a variety of clinical situations involving localized or extended field radiotherapy (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Recovery usually begins shortly after completion of treatment (6,7,12), and continues through the next 1-2 yr.…”

Blood lymphocyte population following 131I treatment for hyperthyroidism

“…Mo¬ nocytes were identified with the aid of Leu M 3 monoclo¬ nal antibodies (Becton Dickinson Co) followed by incu¬ bation with FITC-conjugated F(ab')2 fragments of rabbit anti-mouse IgG (Sigma Chemical Co, St. Louis, MO). Lymphocytes expressing membrane receptors for acti¬ vated C'3 were identified as cells forming rosettes with heterologous erythrocytes treated with specific IgM an¬ tibodies which have been incubated with fresh serum as a source of complement as described (16). These cells will be termed EAC-rosette-forming.…”