Blood Loss Is a Stronger Predictor of Iron Status in Men Than C282Y Heterozygosity or Diet

Heath, Anne‐Louise M; Roe, Mark; Oyston, Sarah L.; Gray, Andrew; Williams, Sheila; Fairweather‐Tait, Susan J.

doi:10.1080/07315724.2008.10719687

Cited by 5 publications

(4 citation statements)

References 39 publications

(46 reference statements)

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“…The findings presented here clearly illustrate that iron deplete IBD patients have a history of low non-haem iron intakes but no difference in percentage availability compared to iron replete subjects. This is in contrast to healthy subjects who, in this study and, as noted above, elsewhere [27,28], seem to be less sensitive to modest changes in non-haem iron intakes/availability in relation to iron status. Nonetheless, it should be noted that haem iron intakes did differ for iron replete versus iron deplete control subjects, so it is possible that this, rather than non-haem iron, contributed to differences in iron status.…”

Section: Discussioncontrasting

confidence: 71%

“…We sought to determine here whether quality and/or quantity of dietary iron ingested was associated with iron status in patients with IBD, even if in the general population such associations are difficult to detect [27,28]. The idea that dietary iron intakes may be more of a determinant of iron status in IBD subjects than the normal healthy population was based on several factors.…”

Section: Discussionmentioning

confidence: 99%

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Iron status is inversely associated with dietary iron intakes in patients with inactive or mildly active inflammatory bowel disease

et al. 2013

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BackgroundPatients with inflammatory bowel disease (IBD) frequently appear iron deplete but whether this is a reflection of dietary iron intakes is not known.MethodsDietary data were collected from 29 patients with inactive or mildly-active IBD and 28 healthy controls using a validated food frequency questionnaire that measured intakes of iron and its absorption modifiers. Non-haem iron availability was estimated using a recently developed algorithm. Subjects were classified for iron status based upon data from a concomitant and separately published study of iron absorption. Absorption was used to define iron status because haematological parameters are flawed in assessing iron status in inflammatory conditions such as IBD.ResultsDietary intakes of total iron, non-haem iron and vitamin C were significantly greater in IBD patients who were iron replete compared to those who were iron deplete (by 48%, 48% and 94% respectively; p≤0.05). The predicted percentage of available non-haem iron did not differ between these groups (19.7 ± 2.0% vs 19.3 ± 2.0% respectively; p=0.25). However, because of the difference in iron intake, the overall amount of absorbed iron did (2.4 ± 0.8 mg/d vs 1.7 ± 0.5 mg/d; p=0.013). No such differences were observed in the healthy control subjects.ConclusionsIn IBD, iron status is more closely related to the quality and quantity of dietary iron intake than in the general healthy population.

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Section: Discussioncontrasting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Iron status is inversely associated with dietary iron intakes in patients with inactive or mildly active inflammatory bowel disease

et al. 2013

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“…When the results of this current study are interpreted in the context of recent evidence indicating that patients with elevated TS are likely to have longer lengths of stay in the hospital, they suggest that elevated TS may be an under-recognized predictor of a patient’s health status (Mainous et al, 2013A). Greater surveillance of the presence of elevated TS may be useful, especially among patients with low health-related quality of life, in notifying patients of their iron status and driving patient behavioral change to reduce iron load (Heath et al, 2008, Bao et al, 2012). …”

Section: Discussionmentioning

confidence: 99%

Elevated transferrin saturation, health-related quality of life and telomere length

et al. 2013

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We sought to examine the relationship between elevated transferrin saturation (TS) and measures of health status (telomere length and patient-reported health-related quality of life) to assess whether elevated TS is associated with negative patient outcomes beyond increased risk for morbidity and mortality, using a cross-sectional analysis of the Hemochromatosis and Iron Overload Screening Study supplemented with assays for leukocyte telomere length in adults ≥25 years old (n=669). Among individuals with elevated TS (≥45% for women and ≥50% for men), who also had a usual source of care, only 5.2% reported ever being told by a doctor that they had an elevated iron condition. In a fully adjusted general linear regression model controlling for demographic characteristics as well as health conditions associated with iron overload, elevated TS versus non-elevated TS was associated with worse general health status (60.4 vs. 63.8, p<0.05), mental health status (76.5 vs. 82.2, p<0.0001) and shorter telomere length (241.4 vs. 261.3, p<0.05). Increased surveillance of elevated TS may be in order as elevated TS is associated with decreased health status and very few patients with elevated TS are aware of their condition.

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“…However, this may be because the distributions of serum ferritin and body iron were considerably lower for women than men. Higher intakes of alcohol are associated with both higher biochemical iron indices [ 45 ] and higher depression [ 46 ], but it is unlikely that the association seen here is because of a confounding effect of alcohol intake in this student population. Data on alcohol intake were collected daily, and controlled for in the analysis.…”

Section: Discussionmentioning

confidence: 99%

Higher Body Iron Is Associated with Greater Depression Symptoms among Young Adult Men but not Women: Observational Data from the Daily Life Study

et al. 2015

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Studies investigating possible associations between iron status and mood or depressive symptoms have reported inconsistent results. However, they have neither used body iron to measure iron status nor measured mood using daily measures. We investigated whether body iron was associated with depressive symptoms, daily mood, daily tiredness, difficulty concentrating, and stress in young adult women and men. Young adult (17–25 years) women (n = 562) and men (n = 323) completed the Center for Epidemiologic Studies Depression Scale, then reported negative and positive mood, and other states daily for 13 days. Non-fasting venous blood was collected to determine hemoglobin, serum ferritin and soluble transferrin receptor (to calculate body iron), C-reactive protein, and alpha-1-acid glycoprotein concentration. Regression models tested linear associations between body iron and the outcome variables, controlling for possible confounders. No associations were found between body iron and the outcome variables in women. However, higher body iron was associated with more depressive symptoms in men (3.4% more per body iron mg/kg; 95% confidence intervals (CI): 0.8%, 5.9%). In young adult women, body iron is unlikely to be associated with significant deficits in mood or depressive symptoms. However, higher body iron may be associated with more depressive symptoms in young adult men.

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Blood Loss Is a Stronger Predictor of Iron Status in Men Than C282Y Heterozygosity or Diet

Abstract: Blood loss was a stronger predictor of iron status than either C282Y heterozygosity or diet in this population of men aged 40 years and over.

Cited by 5 publications

References 39 publications

Iron status is inversely associated with dietary iron intakes in patients with inactive or mildly active inflammatory bowel disease

Iron status is inversely associated with dietary iron intakes in patients with inactive or mildly active inflammatory bowel disease

Elevated transferrin saturation, health-related quality of life and telomere length

Higher Body Iron Is Associated with Greater Depression Symptoms among Young Adult Men but not Women: Observational Data from the Daily Life Study

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