Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition

Abstract

These findings show that high concentrations of serum HDL are associated with a decreased risk of colon cancer. The mechanism behind this association needs further elucidation.

The association between serum lipids and colorectal neoplasm: a systemic review and meta-analysis

“…Nine studies were conducted in the USA (16,18,20,32,35,(37)(38)(39)(40) , one in Sweden (42) , five in Korea (6,9,10,22,27) , two in China (23,30) , eight in Japan (8,24,26,28,29,31,36,43) , one in Austria (41) and three in European countries (4,17,34) (Tables 1 and 2). Pooled analysis showed a significant association between serum TAG and CRN (n 29 studies; summary RR = 1·08; 95 % CI 1·05, 1·12, P < 0·00001; Fig.…”

“…Overall analyses on the association of serum lipids and colorectal cancer Eight publications in the present meta-analysis on TC (four cohort and four case-control studies) and risk of CRC were published between 1992 and 2012 and involved a total of 10 979 CRC cases (Table 1) (4,21,22,25,34,38,42,43) . One study (1992) (38) , USA (2011) (17) , (32) , USA (43) , Japan (2010) (26) , Japan was conducted in the USA (38) , one in Sweden (42) , one in Korea (22) , two in Japan (25,43) , one in Finland (21) and two in European countries (4,34) (Table 1).…”

“…One study (1992) (38) , USA (2011) (17) , (32) , USA (43) , Japan (2010) (26) , Japan was conducted in the USA (38) , one in Sweden (42) , one in Korea (22) , two in Japan (25,43) , one in Finland (21) and two in European countries (4,34) (Table 1). Pooled data did not support the association between TC and CRC (RR = 0·95; 95 % CI 0·85, 1·06, P = 0·38).…”

“…One study was conducted in the USA (33) , one in Sweden (42) and one in European countries (4) (Table 1). The association between serum LDL-C and CRC risk was not observed (RR = 0·88; 95 % CI 0·77, 1·01, P = 0·07).…”

Epidemiology: Disease Associations and Modulators of HDL-Related Biomarkers

“…Special interest has been recently focused on HDL in cancer patients. Several epidemiological studies have shown that low HDL-C level may be a risk and/or prognostic factor of biliary tract cancers (Andreotti et al 2008), prostate cancer (Mondul et al 2011;Kotani et al 2013), colon cancer (van Duijnhoven et al 2011), breast cancer (Furberg et al 2005, Melvin et al 2012) and gastric cancer (Tamura et al 2012), but not that of endometrial cancer (Cust et al 2007;Esposito et al 2014) or rectal cancer (van Duijnhoven et al 2011). Confounding factors related to obesity and metabolic syndrome may be more strongly associated with the latter cancer types (Kotani et al 2013).…”