Blood Levels of Vitamin C, Carotenoids and Retinol Are Inversely Associated with Cataract in a North Indian Population

Dherani, Mukesh; Murthy, Gudlavalleti Venkata Satyanarayana; Gupta, Sanjeev Kumar; Young, Ian S.; Maraini, G; Camparini, Monica; Price, Gill M; John, Nitin Ashok; Chakravarthy, Usha; Fletcher, Astrid

doi:10.1167/iovs.07-1202

Cited by 89 publications

(82 citation statements)

References 52 publications

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“…The blood levels of lutein and zeaxanthin were reported to be 0.101 mol/L and 0.02 mol/L in cataract and 0.114 mol/L and 0.023 mol/L in non-cataract in the northern India population, respectively (38). The macular pigment from this study estimated the northern India cadaver eye levels of lutein and zeaxanthin as 1.4 mol/kg and 1.7 mol/kg, respectively.…”

Section: Discussionmentioning

confidence: 64%

Regional Variation in the Levels of Macular Xanthophylls and Carotenoids in Dietary Components: Comparing North and South India

Velpandian

Arora

Senthilkumari

et al. 2010

J Nutr Sci Vitaminol

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Summary Multiple epidemiological studies have emphasized the intake of dark green leafy vegetables rich in xanthophylls in reducing the risk of developing age-related macular degeneration (AMD). Therefore, the present study was undertaken to quantify the levels of major carotenoids in commonly consumed fruits and vegetables of Indian origin and of xanthophylls in the macula of Indian human donor eyes. Fresh fruits ( n ϭ 20) and vegetables ( n ϭ 51) collected from two zones of India were tested for the estimation of xanthophyll, lycopene and ␤ -carotene by using HPLC with Photodiode Array Detection. Lutein and zeaxanthin were quantified from macula and in selected vegetables collected from both southern (SI) and northern (NI) regions of India. Xanthophylls, ␤ -carotene and lycopene were found in many affordable vegetables commonly available for consumption in India. Higher content of lutein and zeaxanthin was confirmed in many economical leafy vegetables and fruits. Surprisingly, the mean macular levels of lutein and zeaxanthin of SI donor eyes ( n ϭ 13) were found to be significantly ( p Ͻ 0.001) four times less than in NI donor eyes ( n ϭ 15) and the macular levels of Northern India were comparable with reported levels in western populations. The present study showed considerable levels of xanthophylls in many of the commonly consumed fruit and vegetable sources in both parts of India. However, SI donor eyes showed lower levels as compared to NI donors and this warrants further investigation about the bioavailability of xanthophylls in their blood and food intake. The relevance of these findings with prevalence of AMD in South India needs to be explored.

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Section: Discussionmentioning

confidence: 64%

Regional Variation in the Levels of Macular Xanthophylls and Carotenoids in Dietary Components: Comparing North and South India

Velpandian

Arora

Senthilkumari

et al. 2010

J Nutr Sci Vitaminol

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“…Serum tocopherol levels and the risk of age-related cataract A forest plot of the seventeen included studies from fourteen articles (11)(12)(13)18,41,42,46,(48)(49)(50)(51)(54)(55)(56) with 17 194 participants and 4179 cases is shown in Fig. 4.…”

Section: Supplemental Vitamin E Intake and Risk Of Age-related Cataractmentioning

confidence: 99%

Vitamin E and risk of age-related cataract: a meta-analysis

Zhang¹,

Jiang²,

Xie³

et al. 2015

Public Health Nutr.

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Objective: We conducted a meta-analysis to evaluate the relationship between vitamin E and age-related cataract (ARC). Design: The fixed-or random-effect model was selected based on heterogeneity. Meta-regression was used to explore potential sources of between-study heterogeneity. Publication bias was evaluated using Begg's test. The dose-response relationship was assessed by a restricted cubic spline model. Setting: Relevant studies were identified by a search of PubMed and the Cochrane Library to May 2014, without language restrictions. Subjects: Studies involved samples of people of all ages. Results: Dietary vitamin E intake, dietary and supplemental vitamin E intake, and high serum tocopherol levels were significantly associated with decreased risk of ARC, the pooled relative risk was 0·73 (95 % CI 0·58, 0·92), 0·86 (95 % CI 0·75, 0·99) and 0·77 (95 % CI 0·66, 0·91), respectively. Supplemental vitamin E intake was non-significantly associated with ARC risk (relative risk = 0·92; 95 % CI 0·78, 1·07). The findings from dose-response analysis showed evidence of a non-linear association between dietary vitamin E intake and ARC. The risk of ARC decreased with dietary vitamin E intake from 7 mg/d (relative risk = 0·94; 95 % CI 0·90, 0·97). Conclusions: The findings of the meta-analysis indicated that dietary vitamin E intake, dietary and supplemental vitamin E intake, and high level of serum tocopherol might be significantly associated with reduced ARC risk.

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“…Oxidative stress is involved in the process of aging (Kregel and Zhang 2007) and various chronic diseases such as atherosclerosis (Fearon and Faux 2009), diabetes (Ceriello and Motz, 2004) and eye disease (Li et al 2009), whereas fruit and vegetable diets rich in antioxidants such as polyphenols, vitamin C, and carotenoids are correlated with a reduced risk of such chronic diseases (Dherani et al 2008). An excessive amount of reactive oxygen/nitrogen species (ROS/RNS) leading to an imbalance between antioxidants and oxidants can cause oxidative damage in vulnerable targets such as unsaturated fatty acyl chains in membranes, thiol groups in proteins, and nucleic acid bases in DNA (Ceconi et al 2003).…”

Section: Oxidative Stressmentioning

confidence: 99%

Lipid Peroxidation End-Products as a Key of Oxidative Stress: Effect of Antioxidant on Their Production and Transfer of Free Radicals

El-Aal¹

2012

Lipid Peroxidation

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Blood Levels of Vitamin C, Carotenoids and Retinol Are Inversely Associated with Cataract in a North Indian Population

Abstract: Inverse associations were found between cataract and blood antioxidants in an antioxidant-depleted study sample.

Cited by 89 publications

References 52 publications

Regional Variation in the Levels of Macular Xanthophylls and Carotenoids in Dietary Components: Comparing North and South India

Regional Variation in the Levels of Macular Xanthophylls and Carotenoids in Dietary Components: Comparing North and South India

Vitamin E and risk of age-related cataract: a meta-analysis

Lipid Peroxidation End-Products as a Key of Oxidative Stress: Effect of Antioxidant on Their Production and Transfer of Free Radicals

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